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Kurysheva N.I.

Medical Biological University of Innovations and Continuing Education of the Federal Biophysical Center named after A.I. Burnazyan;
Ophthalmological Center of the Federal Medical-Biological Agency at the Federal Biophysical Center named after A.I. Burnazyan

Sharova G.A.

Medical Biological University of Innovations and Continuing Education of the Federal Biophysical Center named after A.I. Burnazyan;
OOO Glaznaya Klinika Doktora Belikovoy

Kalimullina L.R.

Medical Biological University of Innovations and Continuing Education of the State Research Center — Burnasyan Federal Medical Biophysical Center of the Federal Medical-Biological Agency;
Ophthalmological Center of the Federal Medical-Biological Agency of Russia State Research Center — Burnasyan Federal Medical Biophysical Center of the Federal Medical-Biological Agency

The role of iridotrabecular contact in the pathogenesis of primary angle closure disease

Authors:

Kurysheva N.I., Sharova G.A., Kalimullina L.R.

More about the authors

Journal: Russian Annals of Ophthalmology. 2025;141(1): 21‑27

DOI: 10.17116/oftalma202514101121

Read: 1053 times

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Table of contents

THE ROLE OF IRIDOTRABECULAR CONTACT IN THE PATHOGENESIS OF PRIMARY ANGLE CLOSURE DISEASE
THE ROLE OF IRIDOTRABECULAR CONTACT IN THE PATHOGENESIS OF PRIMARY ANGLE CLOSURE DISEASE

To cite this article:

Kurysheva NI, Sharova GA, Kalimullina LR. The role of iridotrabecular contact in the pathogenesis of primary angle closure disease. Russian Annals of Ophthalmology. 2025;141(1):21‑27. (In Russ.)
https://doi.org/10.17116/oftalma202514101121

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Recommended articles:
Inve­stigation of iridotrabecular contact in primary angle closure. Russian Annals of Ophthalmology. 2024;(6):24-31
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Abstract:

PURPOSE

This study investigated the correlation between iridotrabecular contact (ITC) and clinical-anatomical parameters in patients with primary angle closure disease (PACD) based on anterior segment imaging data obtained via swept-source optical coherence tomography (SS-OCT).

MATERIAL AND METHODS

The study analyzed data from 92 patients aged 32—89 years, including 56 patients with PACD (43 phakic and 13 pseudophakic) and 36 control group participants (21 phakic and 15 pseudophakic). All participants underwent SS-OCT imaging of the anterior segment, including measurements of the ITC index and ITC area.

RESULTS

The study revealed that in phakic PACD patients, ITC parameters (ITC Index and ITC Area) were significantly correlated with anterior chamber depth (ACD; r=–0.42, p=0.01 and r=–0.43, p=0.00, respectively), lens vault (LV; r=0.35, p=0.02 and r=0.36, p=0.02, respectively), lens thickness (LT; r=0.47, p=0.01 and r=0.44, p=0.01, respectively), all anterior chamber angle (ACA) parameters (all p=0.00), and the number of hypotensive medications used (r=0.63, p=0.01 and r=0.68, p=0.01, respectively). In pseudophakic PACD patients, ITC Index and ITC Area were associated with the number of hypotensive medications (r=0.71, p=0.02 and r=0.72, p=0.02, respectively) and the iridotrabecular space area in the nasal sector (r=0.62, p=0.02). No significant correlations were observed in the control group, regardless of lens status.

CONCLUSION

ITC parameters in phakic PACD patients demonstrated the highest number of correlations compared to pseudophakic patients. The persistence of a direct relationship between ITC parameters and the number of hypotensive medications in primary angle-closure glaucoma following lens extraction supports the rationale for early surgical intervention.

Keywords:

iridotrabecular contact
primary angle-closure glaucoma
primary angle closure
lens extraction
swept-source optical coherence tomography
CASIA2

Authors:

Kurysheva N.I.

Medical Biological University of Innovations and Continuing Education of the Federal Biophysical Center named after A.I. Burnazyan;
Ophthalmological Center of the Federal Medical-Biological Agency at the Federal Biophysical Center named after A.I. Burnazyan

Sharova G.A.

Medical Biological University of Innovations and Continuing Education of the Federal Biophysical Center named after A.I. Burnazyan;
OOO Glaznaya Klinika Doktora Belikovoy

Kalimullina L.R.

Medical Biological University of Innovations and Continuing Education of the State Research Center — Burnasyan Federal Medical Biophysical Center of the Federal Medical-Biological Agency;
Ophthalmological Center of the Federal Medical-Biological Agency of Russia State Research Center — Burnasyan Federal Medical Biophysical Center of the Federal Medical-Biological Agency

Received:

03.05.2024

Accepted:

24.06.2024

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References:

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