The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Averich V.V.

Krasnov Research Institute of Eye Diseases

Avetisov S.E.

Krasnov Research Institute of Eye Disease;
I.M. Sechenov First Moscow State Medical University (Sechenov University)

Voronin G.V.

Research Institute of Eye Diseases

Results of optical coherence tomography of the retina and optic nerve in keratoconus

Authors:

Averich V.V., Avetisov S.E., Voronin G.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2021;137(5‑2): 275‑280

DOI: 10.17116/oftalma2021137052275

Read: 3195 times

Contact the author
Table of contents

RESULTS OF OPTICAL COHERENCE TOMOGRAPHY OF THE RETINA AND OPTIC NERVE IN KERATOCONUS
RESULTS OF OPTICAL COHERENCE TOMOGRAPHY OF THE RETINA AND OPTIC NERVE IN KERATOCONUS

To cite this article:

Averich VV, Avetisov SE, Voronin GV. Results of optical coherence tomography of the retina and optic nerve in keratoconus. Russian Annals of Ophthalmology. 2021;137(5‑2):275‑280. (In Russ.)
https://doi.org/10.17116/oftalma2021137052275

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Nano­second reti­nal laser therapy: three years of practical expe­rience. Russian Annals of Ophthalmology. 2025;(4):60-65
Femtosecond laser-assisted intrastromal kera­toplasty with biosynthetic complex implantation for kera­toconus (preliminary report). Russian Annals of Ophthalmology. 2025;(4):73-79
Comparative evaluation of tono­metry methods in kera­toconus. Russian Annals of Ophthalmology. 2025;(6):7-13
Mole­cular diagnostic biomarkers of subretinal fluid in asse­ssing the seve­rity and prognosis of rhegmatogenous reti­nal deta­chment. Russian Annals of Ophthalmology. 2025;(6):119-126
Expe­rimental study of a new anti-glaucoma intrascleral implant. Russian Annals of Ophthalmology. 2026;(2):16-20
Clinical case of an inhe­rited reti­nal disease with late mani­festation. Russian Annals of Ophthalmology. 2026;(2):50-55
Antiangiogenic therapy after cata­ract surgery in neovascular age-related macu­lar dege­neration (clinical obse­rvation). Russian Annals of Ophthalmology. 2026;(2):57-62
Terrien’s marginal dege­neration: clinical mani­festations, diagnosis, and treatment. Russian Annals of Ophthalmology. 2026;(2):100-106
Differential asse­ssment of diagnostic signs of primary open-angle glaucoma and high myopia. Russian Annals of Ophthalmology. 2026;(3):86-90
Clinical and economic impact of broader implementation of opti­cal cohe­rence tomo­graphy and anti-VEGF therapy for diabetic reti­nopathy and macu­lar edema in type 1 diabetes. Medi­cal Technologies. Asse­ssment and Choice. 2026;(1):122-133
Abstract:

The article reviews the results of optical coherence tomography (OCT) of the retina and optic nerve in patients with keratoconus (KC). This research direction is premised by the possibility that changes in the retina and optic nerve are associated with KC, as well as the potential influence of significant changes in axial eye length, disorders of corneal refraction and increased level of aberrations on the quality of visualization of these ocular structures. Results of the conducted studies were conflicting, but in all they indicated a possibility of OCT findings to be altered in KC patients. Therefore, the question of changing the parameters for OCT of the retina and optic nerve requires further investigation. The main problem that needs solving with evidence based medical research can be phrased as follows: are the changes in OCT findings observed in KC patients the consequence of changes in the retina and optic nerve associated with this disorder, or potential effect of aberrations and irregular astigmatism on the quality of visualization of the studied structures?

Keywords:

keratoconus
optical coherence tomography
retina
optic nerve head
aberrations

Authors:

Averich V.V.

Krasnov Research Institute of Eye Diseases

Avetisov S.E.

Krasnov Research Institute of Eye Disease;
I.M. Sechenov First Moscow State Medical University (Sechenov University)

Voronin G.V.

Research Institute of Eye Diseases

Received:

28.10.2020

Accepted:

28.12.2020

Close metadata

References:

  1. Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA. Optical coherence tomography. Science. 1991;254(5035):1178-1181. https://doi.org/10.1126/science.1957169
  2. Rabinowitz YS. Keratoconus. Survey of Ophthalmology. 1998;42(4):297-319.  https://doi.org/10.1016/S0039-6257(97)00119-7
  3. Freedman J, Gombos GM. Bilateral macular coloboma, keratoconus and retinitis pigmentosa. Annals of Ophthalmology. 1971;3(6):664-665. 
  4. Leighton DA, Harris R. Retinal aplasia in association with macular coloboma, keratoconus and cataract. Clinical Genetics. 1973;4(3):270-274.  https://doi.org/10.1111/j.1399-0004.1973.tb01154.x
  5. Hameed A, Khaliq S, Ismail M, Anwar K, Ebenezer ND, Jordan T, Bhattacharya SS. A novel locus for Leber Congenital Amaurosis (LCA4) with anterior keratoconus mapping to chromosome 17p13. Investigative Ophthalmology and Visual Science. 1977;41(3):629-633. 
  6. Stockton DW, Lewis RA, Abboud EB, Al-Rajhi A, Jabak M, Anderson KL, Lupski JR. A novel locus for Leber congenital amaurosis on chromosome 14q24. Human Genetics. 1998;103(3):328-333.  https://doi.org/10.1007/s004390050825
  7. Elder MJ. Leber congenital amaurosis and its association with keratoconus and keratoglobus. Journal of Pediatric Ophthalmology and Strabismus. 1994; 31(1):38-40.  https://doi.org/10.3928/0191-3913-19940101-08
  8. Lorfel RS, Sugar HS. Keratoconus associated with retrolental fibroplasia. Annals of Ophthalmology. 1976;8(4):449-450. 
  9. Eandi CM, Del Priore LV, Bertelli E, Ober MD, Yannuzzi LA. Central serous chorioretinopathy in patients with keratoconus. Retina. 2008;28(1):94-96.  https://doi.org/10.1097/IAE.0b013e3180986299
  10. Sammouh FK, Baban TA, Warrak EL. A patient with keratoconus, nanophthalmos, lipodermoids and pigmentary retinopathy. Ophthalmic Genetics. 2016;37(2):228-232.  https://doi.org/10.3109/13816810.2015.1028648
  11. Moschos M, Droutsas D, Panagakis E, Tsioulias G, Tsalouki M. Keratoconus and tapetoretinal degeneration. Cornea. 1996;15(5):473-476.  https://doi.org/10.1097/00003226-199609000-00006
  12. Ascaso FJ, Del Buey MA, Huerva V, Latre B, Palomar A. Noonan’s syndrome with keratoconus and optic disc coloboma. European Journal of Ophthalmology. 1993;3(2):101-103.  https://doi.org/10.1177/112067219300300210
  13. Fasciani R, Mosca L, Giannico ML, Legrottaglie EF, Balestrazzi E. Unusual coexistence of bilateral keratoconus and optic discpit: a case report. European Journal of Ophthalmology. 2008;18(1):134-137.  https://doi.org/10.1177/112067210801800124
  14. Ciftci S. Unilateral tilted disc and ipsilateral keratoconus in the same eye. BMJ Case Reports. 2011;2011:bcr0620103126. https://doi.org/10.1136/bcr.06.2010.3126
  15. Shpak AA, Korobkova MV. Optical coherence tomography in patients with refractive errors. Part 1: The thickness of the peripapillary retinal nerve fiber layer. Oftal’mokhirurgiya. 2017;4:67-72. (In Russ.). https://doi.org/10.25276/0235-4160-2017-4-67-72
  16. Shpak AA, Korobkova MV. Optical coherence tomography in patients with refractive errors. Part 2: Optic disc parameters. Oftal’mokhirurgiya. 2018;1: 60-65. (In Russ.). https://doi.org/10.25276/0235-4160-2018-1-60-65
  17. Shpak AA, Korobkova MV. Optical coherence tomography in patients with refractive errors. Part 3: The thickness of the ganglion cell-inner plexiform layer. Oftal’mokhirurgiya. 2018;2:58-62. (In Russ.). https://doi.org/10.25276/0235-4160-2018-2-58-62
  18. Kang SH, Hong SW, Im SK. Effect of myopia on the thickness of the retinal nerve fiber layer measured by Cirrus HD optical coherence tomography. Investigative Ophthalmology and Visual Science. 2010;51(8):4075-4083. https://doi.org/10.1167/iovs.09-4737
  19. Savini G, Barboni P, Parisi V, Carbonelli M. The influence of axial length on retinal nerve fibre layer thickness and optic-disc size measurements by spectral-domain OCT. British Journal of Ophthalmology. 2012;96(1):57-61.  https://doi.org/10.1136/bjo.2010.196782
  20. Touzeau O, Scheer S, Allouch C, Borderie V, Laroche L. The relationship between keratoconus and axial myopia. Journal Francais D’ophtalmologie. 2004;27(7):765-771.  https://doi.org/10.1016/s0181-5512(04)96211-0
  21. Ernst BJ, Hsu HY. Keratoconus Association with Axial Myopia: A Prospective Biometric Study. Eye and Contact Lens: Science and Clinical Practice. 2011;37(1):2-5.  https://doi.org/10.1097/ICL.0b013e3181fb2119
  22. Avetisov SE, Bolshunov AV, Katalevskaya EA. Study of influence of aberrations of optic eye system on quality of eye fundus imaging in patients with age-related macular degeneration. RMZh. Klinicheskaya oftal’mologiya. 2008;9(1):10-12. (In Russ.).
  23. Kornilovsky IM, Godzhaeva AM. New bioptic approach to evaluation of optic aberrations and restorative vision correction. Refraktsionnaya khirurgiya i oftal’mologiya. 2006;6(1):4-13. (In Russ.).
  24. Balashevich LI. Optical aberrations of the eye: diagnostics and correction. Okulist. 2001;6(22):12-15. (In Russ.).
  25. Lagana MA, Cox IG, Potvin RJ. The effect of keratoconus on the wavefront aberration of the human eye. Investigative Ophthalmology and Visual Science. 2000;41(4):679. 
  26. Klyce SD, Karon MD, Smolek MK. Advantages and disadvantages of the Zernike expansion for representing wave aberration of the normal and aberrated eye. Journal of Refractive Surgery. 2004;20(5):537-541.  https://doi.org/10.3928/1081-597X-20040901-25
  27. Egorova GB, Bobrovskikh NV, Zueva YuS. Optical aberrations of the eye and feasibilities of their compensation by means of contact lenses and surgical interventions in primary ametropias and keratoconus. Vestnik oftal’mologii. 2007;123(5):47-51. (In Russ.).
  28. Egorova GB, Bobrovskikh NV, Savochkina OA. Possibilities of compensation of optical aberrations in keratoconus with rigid gas-permeable contact lenses. Vestnik oftal’mologii. 2010;126(1):42-46. (In Russ.).
  29. Bolshunov AV, Iroshnikov NG, Katalevskaya EA, Larichev AV, Panchenko VYa. Adaptive optics in ophthalmology. Meditsinskaya fizika. 2008; 38(2):57-62. (In Russ.).
  30. Shpak AA, Kostenev SV, Mushkova IA, Korobkova MV. Effect of corneal refractive surgery on optical coherence tomography measurements. Vestnik oftal’mologii. 2018;134(5):48-53. (In Russ.). https://doi.org/10.17116/oftalma201813405148
  31. Keir NJ, Simpson T, Jones LW, Fonn D. Wavefront-guided LASIK for myopia: effect on visual acuity, contrast sensitivity, and higher order aberrations. Journal of Refractive Surgery. 2009;25(6):524-533.  https://doi.org/10.3928/1081597X-20090512-06
  32. Oshika T, Miyata K, Tokunaga T, Samejima T, Amano S, Tanaka S, Fujikado T. Higher order wavefront aberrations of cornea and magnitude of refractive correction in laser in situ keratomileusis. Ophthalmology. 2002;109(6): 1154-1158. https://doi.org/10.1016/S0161-6420(02)01028-X8
  33. McAlinden C, Moore JE. Comparison of higher order aberrations after LASIK and LASEK for myopia. Journal of Refractive Surgery. 2010;26(1):45-51.  https://doi.org/10.3928/1081597X-20101215-07
  34. Padmanabhan P, Basuthkar SS, Joseph R. Ocular aberrations after wavefront optimized LASIK for myopia. Indian Journal of Ophthalmology. 2010;58(4): 307-312.  https://doi.org/10.4103/0301-4738.64139
  35. Pozdeeva NA, Shkolnik GS, Pateeva TZ, Fedotova LA. Spatial contrast sensitivity and higher-order aberrations after various refractive laser operations in the early postoperative period. Vestnik Orenburgskogo gosudarstvennogo universiteta. 2009;118(12-2):115-119. (In Russ.).
  36. Doga AV, Mushkova IA, Kachalina GF, Ivanova EV. Comparative evaluation of the dynamics of spherical aberration in hypermetropia correction by LASIK and laser thermokeratoplasty (LTK). Sibirskij nauchnyj meditsinskij zhurnal. 2010;30(5):133-136. (In Russ.).
  37. Deonarain S, Motala A, Mthembu T, Nxele N, Phakathi T, Gcabashe N, Rampersad N. Macular thicknesses in patients with keratoconus: An optical coherence tomography study. African Vision and Eye Health. 2019;78(1):a482. https://doi.org/10.4102/aveh.v78i1.482
  38. Brautaset RL, Rosén R, Cerviño A, Miller WL, Bergmanson J, Nilsson M. Comparison of macular thickness in patients with keratoconus and control subjects using the Cirrus HD-OCT. BioMed Research International. 2015; 2015:832863. https://doi.org/10.1155/2015/832863
  39. Moschos MM, Chatziralli IP, Koutsandrea C, Siasou G, Droutsas D. Assessment of the macula in keratoconus: An optical coherence tomography and multifocal electroretinography study. Ophthalmologica. 2013;229(4):203-207.  https://doi.org/10.1159/000350801
  40. Yilmaz I, Saracoglu Yilmaz B, Guleryuz NB, Perente I, Ozkaya A, Taskapili M. Assessment of the macula and choroid in pediatric keratoconus patients. Saudi Journal of Ophthalmology. 2018;32(2):126-129.  https://doi.org/10.1016/J.SJOPT.2017.10.010
  41. Sahebjada S, Amirul Islam FM, Wickremasinghe S, Daniell M, Baird PN. Assessment of macular parameter changes in patients with keratoconus using optical coherence tomography. Journal of Ophthalmology. 2015;2015: 245953. https://doi.org/10.1155/2015/245953
  42. Cuppusamy P, Makhanya N, Methula M, Essop KM, Sibisi D, Wohabally N, Wohabally N, Gcabashe N, Rampersad N. Retinal nerve fibre layer and ganglion cell complex thickness in patients with keratoconus. African Vision and Eye Health. 2018;77(1):a417. https://doi.org/10.4102/aveh.v77i1.417
  43. Cankaya AB, Beyazyildiz E, Ileri D, Yilmazbas P. Optic disc and retinal nerve fiber layer parameters of eyes with keratoconus. Ophthalmic Surgery, Lasers and Imaging. 2012;43(5):401-407.  https://doi.org/10.3928/15428877-20120531-01
  44. Uzunel UD, Küsbeci T, Yüksel B. Does the stage of Keratoconus affect optical coherence tomography measurements? Seminars in Ophthalmology. 2017;32(6):676-681.  https://doi.org/10.3109/08820538.2016.1169302
  45. Podtynnykh EV, Komarovskikh EN. Morphometric changes of optic nerve and retina in keratoconus in patients, related to changes in glaucoma. Natsional’nyj zhurnal Glaukoma. 2018;17(3):15-23. (In Russ.). https://doi.org/10.25700/NJG.2018.03.02
  46. Podtynnykh EV, Komarovskikh EN, Tregubov VG. Undifferentiated connective tissue dysplasia as a risk factor of keratoconus development and pathological changes of optic nerve and retina. Natsional’nyj zhurnal Glaukoma. 2019;18(3):45-53. (In Russ.). https://doi.org/10.25700/NJG.2019.03.05
  47. Bayhan SA, Bayhan HA, Gurdal C. Evaluation of the retinal nerve fiber layer and ganglion cell complex thickness with keratoconus. Turkiye Klinikleri Journal of Ophthalmology. 2014;23:207-211. 
  48. Reibaldi M, Uva MG, Avitabile T, Toro MD, Zagari M, Mariotti C, Longo A. Intrasession reproducibility of RNFL thickness measurements using SD-OCT in eyes with keratoconus. Ophthalmic Surgery, Lasers and Imaging Retina. 2012;43(6):83-89.  https://doi.org/10.3928/15428877-20121001-04
  49. Gutierrez-Bonet R, Ruiz-Medrano J, Biarnés M, Rasheed MA, Vupparaboina KK, Chhablani J, Ruiz-Moreno JM. Analysis of Choroidal Vascularity Index in Keratoconus Patients Using Swept-Source Optical Coherence Tomography-Based Binarization Techniques. Journal of Ophthalmology. 2020;2020:1-10.  https://doi.org/10.1155/2020/1682463
  50. Gutierrez-Bonet R, Ruiz-Medrano J, Pena-Garcia P, Catanese M, Sadeghi Y, Hashemi K, Ruiz-Moreno JM. Macular choroidal thickening in keratoconus patients: swept-source optical coherence tomography study. Translational Vision Science and TECHNology. 2018;7(3):15-15.  https://doi.org/10.1167/tvst.7.3.15
  51. Bilgin B, Karadag AS. Choroidal thickness in keratoconus. International Ophthalmology. 2020;40(1):135-140.  https://doi.org/10.1007/s10792-019-01156-y
  52. Akkaya S. Macular and peripapillary choroidal thickness in patients with keratoconus. Ophthalmic Surgery, Lasers and Imaging Retina. 2018;49(9):664-673.  https://doi.org/10.3928/23258160-20180831-03
  53. Pinheiro-Costa J, Viana Pinto J, Perestrelo S, Beato JN, Torrão L, Brandão E, Falcão-Reis F. Increased Choroidal Thickness in Keratoconus Patients: Perspectives in the Disease Pathophysiology. Journal of Ophthalmology. 2019;2019:1-7.  https://doi.org/10.1155/2019/2453931
  54. Wisse RP, Kuiper JJ, Gans RS, Imhof DJ, Radstake TR, Van der Lelij A. Cytokine expressionin keratoconus and its corneal microenvironment: a systematicreview. The Ocular Surface. 2015;13(4):272-283.  https://doi.org/10.1016/j.jtos.2015.04.006
  55. Galvis V, Sherwin T, Tello A, Merayo J, Barrera R, Acera A. Keratoconus: an inflammatory disorder? Eye. 2015;29(7):843-859.  https://doi.org/10.1038/eye.2015.63
  56. Sorkhabi R, Ghorbanihaghjo A, Taheri N, Ahoor MH. Tear film inflammatory mediators in patients with keratoconus. International Ophthalmology. 2015;35(4):467-472.  https://doi.org/10.1007/s10792-014-9971-3
  57. Samarawickrama C, Pai A, Huynh SC, Burlutsky G, Wong TY, Mitchell P. Influence of OCT signal strength on macular, optic nerve head, and retinal nerve fiber layer parameters. Investigative Ophthalmology and Visual Science. 2010;51(9):4471-4475. https://doi.org/10.1167/iovs.09-3892
  58. Vizzeri G, Bowd C, Medeiros FA, Weinreb RN, Zangwill LM. Effect of signal strength and improper alignment on the variability of stratus optical coherence tomography retinal nerve fiber layer thickness measurements. American Journal of Ophthalmology. 2009;148(2):249-255.  https://doi.org/10.1016/j.ajo.2009.03.002
  59. Cheung CYL, Leung CKS, Lin D, Pang CP, Lam DSC. Relationship between retinal nerve fiber layer measurement and signal strength in optical coherence tomography. Ophthalmology. 2008;115(8):1347-1351. https://doi.org/10.1016/j.ophtha.2007.11.027
  60. Uzunel UD, Kusbeci T, Yuce B, Yüksel B. Effects of rigid contact lenses on optical coherence tomographic parameters in eyes with keratoconus. Clinical and Experimental Optometry. 2015;98(4):319-322.  https://doi.org/10.1111/cxo.12287
  61. Hwang YH, Lee SM, Kim YY, Lee JY, Yoo C. Astigmatism and optical coherence tomography measurements. Graefe’s Archive for Clinical and Experimental Ophthalmology. 2012;250(2):247-254.  https://doi.org/10.1007/s00417-011-1788-4
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.