Viral and non-viral infections in the etiopathogenesis of uveitis

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Krichevskaia G.I.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Katargina L.A.

Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia

Viral and non-viral infections in the etiopathogenesis of uveitis

Authors:

Krichevskaia G.I., Katargina L.A.

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Journal: Russian Annals of Ophthalmology. 2020;136(1): 124‑129

DOI: 10.17116/oftalma2020136011124

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To cite this article:

Krichevskaia GI, Katargina LA. Viral and non-viral infections in the etiopathogenesis of uveitis. Russian Annals of Ophthalmology. 2020;136(1):124‑129. (In Russ.)
https://doi.org/10.17116/oftalma2020136011124

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

Использование инфографики авторами научных работ

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Abstract:

The article reviews literature and proprietary data on the role of pathogens in the etiology of infectious and non-infectious uveitis. Infectious uveitis is caused by active intraocular replication of the virus (herpesvirus, acute stage of enterovirus), or by long-term persistence of the viruses in eye tissues (Fuchs syndrome associated with rubella virus, late complications of enterovirus uveitis). Clinical picture, severity, outcomes of infectious uveitis depend on the pathogen, adequacy of the immune response and genetic characteristics of the patient. Infections trigger the development of non-infectious uveitis, including autoimmune. Their trigger mechanisms involve antigenic mimicry, bystander activation, epitope spreading, presence of superantigens, intestinal microbiota. An uncontrolled, excessive host immune response contributes to cell destruction even after removal of the infection.

Keywords:

infectious uveitis

non-infectious uveitis

human herpesviruses

enteroviruses

rubella virus

arboviruses

antigenic mimicry

epitope spreading

bystander activation

gut microbiota

Authors:

Krichevskaia G.I.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Katargina L.A.

Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia

Close metadata

References:

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