Structural and functional changes in the retina of patients with primary open-angle glaucoma and compensated intraocular pressure while undergoing retinoprotective therapy (in Russian only)

Egorov E.A.

RNIMU im. N.I. Pirogova

SPIN RSCI: 9704-9451
Scopus AuthorID: 7103143758
ORCID: 0000-0002-1132-8031

Erichev V.P.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Strahov V.V.

Kafedra oftal'mologii Jaroslavskogo gosudarstvennogo meditsinskogo universiteta, ul. Revoljutsionnaja, 5, Jaroslavl', Rossijskaja Federatsija, 150000

SPIN RSCI: 7887-2560
Scopus AuthorID: 7103202082
ORCID: 0000-0003-3179-1303

Petrov S.Iu.

FGBU "NII glaznykh bolezneĭ" RAMN

Romanova T.B.

Pirogov Russian National Research Medical University, Department of Ophthalmology, 23 Veshnyakovskaya St., Moscow, Russian Federation, 111539

Vasina M.V.

Ophthalmological Center 'Doctor Visus', 14 Kalanchevskaya St., Moscow, Russian Federation, 129090

Zinina V.S.

Research Institute of Eye Diseases, 11, A, B, Rossolimo St., Moscow, Russian Federation, 119021

Makarova А.S.

Research Institute of Eye Diseases, 11 A, B, Rossolimo St., Moscow, Russian Federation, 119021

Kazanova S.Yu.

Yaroslavl State Medical University, Department of Ophthalmology, 5 Revolyutsionnaya St., Yaroslavl, Russian Federation, 150000

Yartsev A.V.

Yaroslavl State Medical University, Department of Ophthalmology, 5 Revolyutsionnaya St., Yaroslavl, Russian Federation, 150000

Structural and functional changes in the retina of patients with primary open-angle glaucoma and compensated intraocular pressure while undergoing retinoprotective therapy (in Russian only)

Authors:

Egorov E.A., Erichev V.P., Strahov V.V., Petrov S.Iu., Romanova T.B., Vasina M.V., Zinina V.S., Makarova А.S., Kazanova S.Yu., Yartsev A.V.

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Journal: Russian Annals of Ophthalmology. 2019;135(3): 20‑30

DOI: 10.17116/oftalma201913503120

Downloaded: 111

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To cite this article:

Egorov EA, Erichev VP, Strahov VV, et al. . Structural and functional changes in the retina of patients with primary open-angle glaucoma and compensated intraocular pressure while undergoing retinoprotective therapy (in Russian only). Russian Annals of Ophthalmology. 2019;135(3):20‑30. (In Russ.)
https://doi.org/10.17116/oftalma201913503120

Подписка 2025-2 (Russian Annals of Ophthalmology)

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Purpose — to evaluate the efficacy and safety of intramuscular Retinalamin for retinoprotection in patients with open-angle glaucoma and normalized intraocular pressure (IOP). Material and methods. The study included 180 patients (355 eyes) randomized into the main (n=90) and control groups (n=90). The patients of the main group received intramuscular Retinalamin injections; the course was repeated 6 months later. Patient examination was performed at 1, 3, 6, 7, 9 and 12 months. Results. Vision acuity did not change in the main group after the treatment courses (p=0.3732, p=0.6862), nor in the control group (p=0.7751). IOP didn’t have significant changes during the whole course of the study neither in the main group (p=0.7632), nor in the control group (p=0.3921). MD index in the main group has increased from –5.52±2.76 to –4.82±2.73 dB (measurements from 6 visits: p=0.0391, p=0.0201, p=0.0302, p=0.3708, p=0.0151, p=0.0353). Control group showed negative MD trend (from –3.51±1.84 to –4.60±2.61 dB; p=0.0012). PSD index has changed from 4.63±1.60 to 4.05±1.43 dB (p=0.0081) in the main group, and from 3.73±1.19 to 4.29±1.53 dB (p=0.0027) in the control group. Average thickness of retinal nerve fiber layer (RNFL) and the volume of neuroretinal rim were stable in both the main (p=0.8039, p=0.9005) and the control groups (p=0.7448, p=0.9620). Ganglion cell complex (GCC) thickness remained stable in the main group (p=0.0377), but has decreased in the control group (p=0.0250). P50 amplitude and latency were stable in the main group (6.54±2.61—6.53±2.64 µV, p=0.0479; 48.39±3.69—50.86±4.09 ms, p=0.0271), while in the control group P50 amplitude has decreased (p=0,0031) and the latency has increased (p=0,0194). In the main group, N95 amplitude has stabilized (p=0.0141) with worsened latency (p=0.0492). N95 amplitude in the control group has worsened (p=0.0195), while latency has stabilized (p=0.3401). Conclusion. Systemic use of Retinalamin has significant retinoprotective effect confirmed by the dynamics of morphological and functional parameters in patients with POAG and IOP compensation.

Keywords:

glaucoma

neuroprotection

retinoprotection

Retinalamin

Authors:

Egorov E.A.

RNIMU im. N.I. Pirogova

SPIN RSCI: 9704-9451
Scopus AuthorID: 7103143758
ORCID: 0000-0002-1132-8031

Erichev V.P.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Strahov V.V.

Kafedra oftal'mologii Jaroslavskogo gosudarstvennogo meditsinskogo universiteta, ul. Revoljutsionnaja, 5, Jaroslavl', Rossijskaja Federatsija, 150000

SPIN RSCI: 7887-2560
Scopus AuthorID: 7103202082
ORCID: 0000-0003-3179-1303

Petrov S.Iu.

FGBU "NII glaznykh bolezneĭ" RAMN

Romanova T.B.

Pirogov Russian National Research Medical University, Department of Ophthalmology, 23 Veshnyakovskaya St., Moscow, Russian Federation, 111539

Vasina M.V.

Ophthalmological Center 'Doctor Visus', 14 Kalanchevskaya St., Moscow, Russian Federation, 129090

Zinina V.S.

Research Institute of Eye Diseases, 11, A, B, Rossolimo St., Moscow, Russian Federation, 119021

Makarova А.S.

Research Institute of Eye Diseases, 11 A, B, Rossolimo St., Moscow, Russian Federation, 119021

Kazanova S.Yu.

Yaroslavl State Medical University, Department of Ophthalmology, 5 Revolyutsionnaya St., Yaroslavl, Russian Federation, 150000

Yartsev A.V.

Yaroslavl State Medical University, Department of Ophthalmology, 5 Revolyutsionnaya St., Yaroslavl, Russian Federation, 150000

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