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Eliseeva N.M.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Serova N.K.

NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva

Erichev V.P.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Panyushkina L.A.

Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021

Structural retinal and optic nerve changes in patients with post-geniculate visual pathway damage

Authors:

Eliseeva N.M., Serova N.K., Erichev V.P., Panyushkina L.A.

More about the authors

Journal: Russian Annals of Ophthalmology. 2017;133(4): 25‑30

DOI: 10.17116/oftalma2017133425-30

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To cite this article:

Eliseeva NM, Serova NK, Erichev VP, Panyushkina LA. Structural retinal and optic nerve changes in patients with post-geniculate visual pathway damage. Russian Annals of Ophthalmology. 2017;133(4):25‑30. (In Russ.)
https://doi.org/10.17116/oftalma2017133425-30

Подписка 2025 (Russian Annals of Ophthalmology)
 
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Aim — to establish the possibility of retrograde trans-synaptic neural degeneration following acquired post-geniculate visual pathway damage. Material and methods. Twenty-two patients with homonymous hemianopia caused by acquired post-geniculate visual pathway damage were examined. Peripapillary retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC) measurements were assessed with RTVue-100 Fourier-domain optical coherence tomography (OCT). Results. In 12 out of 22 patients we detected binocular GCC thinning that was ipsilateral to post-geniculate involvement. Nine patients showed a decrease in the RNFL thickness. However, topographic correspondence between the post-geniculate lesion and RNFL thickness was established for 2 of them only. GCC thinning was more common in patients with hemianopsia acquired more than 6 months ago (p<0.0009). Conclusion. Having assessed the ganglion cell complex and retinal nerve fiber layer with OCT, we have proved possible that trans-synaptic retrograde degeneration develops in patients with post-geniculate visual pathway damage.

Keywords:

retrograde trans-synaptic degeneration
post-geniculate visual pathway
homonymous hemianopia
optical coherence tomography

Authors:

Eliseeva N.M.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Serova N.K.

NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva

Erichev V.P.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Panyushkina L.A.

Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021

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