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Slepova O.S.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdravsotsrazvitiia Rossii

Eremeeva E.A.

Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062

Riabina M.V.

FGBU Moskovskiĭ nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ im. Gel'mgol'tsa Minzdrava RF, Moskva

Sorozhkina E.S.

Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062

Role of infection in the pathogenesis of age-related macular degeneration

Authors:

Slepova O.S., Eremeeva E.A., Riabina M.V., Sorozhkina E.S.

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Journal: Russian Annals of Ophthalmology. 2015;131(4): 56‑59

DOI: 10.17116/oftalma2015131456-59

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To cite this article:

Slepova OS, Eremeeva EA, Riabina MV, Sorozhkina ES. Role of infection in the pathogenesis of age-related macular degeneration. Russian Annals of Ophthalmology. 2015;131(4):56‑59. (In Russ.)
https://doi.org/10.17116/oftalma2015131456-59

Подписка 2025 (Russian Annals of Ophthalmology)
 
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Aim — to study the role of infectious agents in the development and progression of AMD by means of serodiagnostic assay for a complex of ophthalmotropic and opportunistic infections. Material and methods. The study enrolled 61 patients (23 men, 38 women) aged 43—68 years and diagnosed in accordance with AREDS classification of AMD. Serodiagnostic tests were performed for 11 infections with the purpose of identifying antigen-specific antibodies in the serum. Results. Activation markers of one or several infections were detected in most of the patients with AMD. Conclusion. Herpes viruses (HSV1 and CMV) along with some opportunistic pathogens are important factors in the pathogenesis of AMD, thereby, specific treatment should be performed in these patients.

Keywords:

age-related macular degeneration
infection
antibodies

Authors:

Slepova O.S.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdravsotsrazvitiia Rossii

Eremeeva E.A.

Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062

Riabina M.V.

FGBU Moskovskiĭ nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ im. Gel'mgol'tsa Minzdrava RF, Moskva

Sorozhkina E.S.

Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062

List of references:

  1. Mukhamed'ianova A, Aznabaev R, Aznabaeva A. Clinical and immunological factors of the onset and development of age-related macular degeneration. Vestnik Oftal’mologii. 2014;13(3):9-13. (In Russ.)
  2. Penfold PL, Madigan MC, Gillies MC, Provis JM. Immunological and aetiological aspects of macular degeneration. Progress in Retinal and Eye-Research. 2001;20(3):385-414. doi:10.1016/s1350-9462(00)00025-2
  3. Jayakrishna Ambati, Atkinson JP, Gelfand BD. Immunology of age-related macular degeneration. Nature Reviews Immunology. 2013;13:438-451. doi:10.1038/ nri 3459
  4. Kalayoglu MV, Bulal D, Aarroyo J, Gragoudas ES, Miller JW. Identification of Ghlamydia pneumaneu within human choroidal neovascular membranes secondary to age-related macular degeneration. Graefes Arch Clin Exp Ophtalmol. 2005;243:1080-1169. doi:10.1007/s00417-00501169-y
  5. Cousins WS, Espinosa-Heidmann DG, Miller DM, Pereira-Simon S, Hernandez EP, Chien H, Meier-Jewett C, Dix RD. Macrophage activation associated with chronic murine cytomegalovirus infection results in more severe experimental choroidal neovascularisation. PLoS Pathogens. 2012;8(4). Available all. doi:10.1371/journal.ppot.1002671
  6. Miller DM, Espinosa-Heidman DG, Legra J, Dubovy SR, Suner IJ, Sedmak DD, Dix RD Cousins SW. The association of prior cytomegalovirus infection with neovascular age-related macular degeneration. A J Ophthalmol. 2004;138(3):323-328. doi:10/1016/j.ago.2004.03.018
  7. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS. Arch Ophthalmol. 2001;119:1417-1436. doi:10.1038/nm950
  8. Neroyev V, Ryabina M, Chikovani K, Neroeva N. Modern ideas and approaches to the treatment of age-related macular degeneration. Rossiiskii oftal'mologicheskii zhurnal. 2008;1(1):6-9. (In Russ.)
  9. Krichevskaya G, Tancovskiy V. The value of serological tests for the choice of an adequate anti-inflammatory therapy for vitreoretinal pathology. Rossiiskii obshchenatsional'nyi oftal'molgicheskii forum. 2009;(2):79-82. (In Russ.)
  10. Ambati J, Anand A, Fernandez S, Sakurai E, Lynn BC, Kuziel WA, Rollins BJ, Ambati BK. An animal model of era-related macular degeneration in senescent Ccl-2-or Ccr-2-defecient mice. Nat-Med. 2003;9(11):1390-1397. doi:10.1038/nm950

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