Evaluation of the pro- and antioxidant status of women with HIV or coinfection

Kolesnikova L.I.; Kolesnikov S.I.; Darenskaya M.A.; Grebenkina L.A.; Timofeeva E.V.; Leshchenko O.Ya.; Vanteeva O.A.; Rashidova M.A.

doi:https://doi.org/10.17116/terarkh2016881117-21

Kolesnikova L.I.

FGBU "Nauchnyĭ tsentr problem zdorov'ia sem'i i reproduktsii cheloveka" Sibirskogo otdeleniia RAMN, Irkutsk

Kolesnikov S.I.

Research Centre for Problems of Family Health and Human Reproduction, Irkutsk, Russia

Darenskaya M.A.

Research Centre for Problems of Family Health and Human Reproduction, Irkutsk, Russia

Grebenkina L.A.

Sleep Center, Research Centre for Problems of Family Health and Human Reproduction, Irkutsk, Russia

Timofeeva E.V.

Research Centre for Problems of Family Health and Human Reproduction, Irkutsk, Russia

Leshchenko O.Ya.

Research Centre for Problems of Family Health and Human Reproduction, Irkutsk, Russia

Vanteeva O.A.

Research Centre for Problems of Family Health and Human Reproduction, Irkutsk, Russia

Rashidova M.A.

Azerbaĭdzhanskiĭ Meditsinskiĭ Universitet, Baku

Evaluation of the pro- and antioxidant status of women with HIV or coinfection

Authors:

Kolesnikova L.I., Kolesnikov S.I., Darenskaya M.A., Grebenkina L.A., Timofeeva E.V., Leshchenko O.Ya., Vanteeva O.A., Rashidova M.A.

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Journal: Therapeutic Archive. 2016;88(11): 17‑21

DOI: 10.17116/terarkh2016881117-21

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To cite this article:

Kolesnikova LI, Kolesnikov SI, Darenskaya MA, et al. . Evaluation of the pro- and antioxidant status of women with HIV or coinfection. Therapeutic Archive. 2016;88(11):17‑21. (In Russ.)
https://doi.org/10.17116/terarkh2016881117-21

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Abstract:

Aim. To reveal the specific features of changes in the parameters of lipid peroxidation – antioxidant defense and the status of the reproductive system in women of fertile age with monoinfection (HIV) or coinfection (HIV and hepatitis B and/or C). Subjects and methods. 81 reproductive-aged women were examined and divided into 3 groups: 1) 28 apparently healthy women (controls); 2) 26 patients with HIV monoinfection; and 3) 27 patients with HIV coinfection (HIV + hepatitis B and/or C) who had not previously received antiretroviral therapy. Results. The HIV coinfection group showed the higher values of primary (conjugated dienes) and secondary (ketodienes and conjugated trienes) lipid peroxidation products in the presence of lower superoxide dismutase activity and obvious α-tocopherol deficiency than the control and HIV monoinfection groups. HIV coinfection in reproductive-aged women was accompanied by the high frequency of luteal phase deficiency. Conclusion. HIV coinfection is characterized by a more pronounced oxidative stress, antioxidant factor deficiency, and the high frequency of luteal phase deficiency in the patients.

Keywords:

HIV

coinfection

hepatitis

reproductive system

oxidative stress

antioxidants

Authors:

Kolesnikova L.I.

FGBU "Nauchnyĭ tsentr problem zdorov'ia sem'i i reproduktsii cheloveka" Sibirskogo otdeleniia RAMN, Irkutsk

Kolesnikov S.I.

Research Centre for Problems of Family Health and Human Reproduction, Irkutsk, Russia

Darenskaya M.A.

Research Centre for Problems of Family Health and Human Reproduction, Irkutsk, Russia

Grebenkina L.A.

Sleep Center, Research Centre for Problems of Family Health and Human Reproduction, Irkutsk, Russia

Timofeeva E.V.

Research Centre for Problems of Family Health and Human Reproduction, Irkutsk, Russia

Leshchenko O.Ya.

Research Centre for Problems of Family Health and Human Reproduction, Irkutsk, Russia

Vanteeva O.A.

Research Centre for Problems of Family Health and Human Reproduction, Irkutsk, Russia

Rashidova M.A.

Azerbaĭdzhanskiĭ Meditsinskiĭ Universitet, Baku

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References:

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