Aim. To examine the relation between coronary atherosclerosis (CA), coronary artery calcification (CAC), and bone mineral density (BMD) in men with coronary artery disease (CAD). Subjects and methods. The investigation included 74 males aged 60.1 (range, 55-70) years with verified CAD. All the patients underwent X-ray contrast-enhanced selective coronary angiography and coronary artery calcium score (CS) and BMD measurements by osteodensitometry. The severity of a coronary artery lesion was evaluated using the SYNTAX score. According to the T score, the patients were divided into 3 groups: 1) 23 patients with osteoporosis (OP), 2) 30 patients with osteopenia, and 3) 21 patients with normal BMD. Results. Osteopenic syndrome (OS) (OP and osteopenia) was found in 71.6% of the patients with angiographically confirmed CAD. Single-vessel lesion in the coronary bed (CB) was more frequently recorded in the normal BMD group than in the OP one (p=0.023). Severe CB lesion was more common for the patients with OP (p=0.029). There were statistically significant differences between the osteopenia and normal BMD groups in the severe degree of CB lesion (p=0.042). Differences were noted in total CS between Groups 1 and 2 (p=0.0122). CS significantly correlated with the severity of CA lesion according to the SYNTAX score (r=0.53; p=0.002). Conclusion. Severe CB lesion in males correlates with CAC and is associated with decreased BMD, suggesting the commonness of the pathogenetic components of AS and OS.