Application of BMP-2 for bone regeneration in osteoporosis

Kuznetsova V.S.; Sinelnikova V.A.; Vasilyev A.V.

doi:https://doi.org/10.17116/stomat2025104031101

Кузнецова В.С.

ФГБНУ «Медико-генетический научный центр им. акад. Н.П. Бочкова»;
ФГБУ НМИЦ «Центральный научно-исследовательский институт стоматологии и челюстно-лицевой хирургии» Минздрава России

ORCID: 0000-0001-8643-1642

Синельникова В.А.

ФГБУ НМИЦ «Центральный научно-исследовательский институт стоматологии и челюстно-лицевой хирургии» Минздрава России

ORCID: 0009-0001-2417-2793

Васильев А.В.

ORCID: 0000-0002-7169-2724

Применение BMP-2 для регенерации костной ткани при остеопорозе

Авторы:

Кузнецова В.С., Синельникова В.А., Васильев А.В.

Подробнее об авторах

Журнал: Стоматология. 2025;104(3): 101‑108

DOI: 10.17116/stomat2025104031101

Прочитано: 540 раз

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Оглавление

Как цитировать:

Кузнецова В.С., Синельникова В.А., Васильев А.В. Применение BMP-2 для регенерации костной ткани при остеопорозе. Стоматология. 2025;104(3):101‑108.
Kuznetsova VS, Sinelnikova VA, Vasilyev AV. Application of BMP-2 for bone regeneration in osteoporosis. Stomatology. 2025;104(3):101‑108. (In Russ.)
https://doi.org/10.17116/stomat2025104031101

Подписка 2026 Стоматология (Stomatology)

Использование инфографики авторами научных работ

Резюме / Abstract:

В обзоре рассмотрены возможности применения костного морфогенетического белка-2 (BMP-2) для регенерации костной ткани при остеопорозе. Произведен анализ исследований воздействия BMP-2 на регенерацию костной ткани in vitro, in vivo, а также описаны результаты клинического применения остеоиндуктора и возможные осложнения.

Ключевые слова / Keywords:

BMP-2

остеопороз

регенераций костной ткани

Авторы / Authors:

Кузнецова В.С.

ORCID: 0000-0001-8643-1642

Синельникова В.А.

ORCID: 0009-0001-2417-2793

Васильев А.В.

ORCID: 0000-0002-7169-2724

Дата поступления:

13.03.2025

Дата принятия в печать:

16.04.2025

Закрыть метаданные

Литература / References:

Salari N, Darvishi N, Bartina Y, Larti M, Kiaei A, Hemmati M, Shohaimi S, Mohammadi M. Global Prevalence of Osteoporosis among the World Older Adults: A Comprehensive Systematic Review and Meta-Analysis. J. Orthop. Surg. 2021;16:669. https://doi.org/10.1186/s13018-021-02821-8
Zhu Z, Yu P, Wu Y, Wu Y, Tan Z, Ling J, Ma J, Zhang J, Zhu W, Liu X. Sex Specific Global Burden of Osteoporosis in 204 Countries and Territories, from 1990 to 2030: An Age-Period-Cohort Modeling Study. J. Nutr. Health Aging 2023;27:767–774. https://doi.org/10.1007/s12603-023-1971-4
Liu F, Wang X, He Y, Han R, Wang T, Guo Y. Jaw Osteoporosis: Challenges to Oral Health and Emerging Perspectives of Treatment. Biomed. Pharmacother. 2024;177:116995. https://doi.org/10.1016/j.biopha.2024.116995
Shibli JA, Naddeo V, Cotrim KC, Kalil EC, de Avila ED, Faot F, Faverani LP, Souza JGS, Fernandes JCH, Fernandes GVO. Osteoporosis’ Effects on Dental Implants Osseointegration and Survival Rate: A Systematic Review of Clinical Studies. Quintessence Int. Berl. Ger. 1985, 2025. https://doi.org/10.3290/j.qi.b5927487
Gonzalez M, Fuentes R, Triplett R, Triplett S. BMP-2 Used for Maxillary Sinus Augmentation and Implant Placement: 15 Years Follow-Up After Final Restorations. J. Oral Maxillofac. Surg. 2011:69:e51. https://doi.org/10.1016/j.joms.2011.06.098
Kuznetsova VS, Vasilyev AV, Buharova TB, Goldshtein DV, Kulakov AA. Safety and Efficacy of BMP-2 and BMP-7 Use in Dentistry. Stomatologiya. 2019;98:64. https://doi.org/10.17116/stomat20199801164
Burkus JK, Sandhu HS, Gornet MF. Influence of rhBMP-2 on the Healing Patterns Associated With Allograft Interbody Constructs in Comparison With Autograft: Spine. 2006:31:775-781. https://doi.org/10.1097/01.brs.0000206357.88287.5a
Fu R, Selph S, McDonagh M, Peterson K, Tiwari A, Chou R, Helfand M. Effectiveness and Harms of Recombinant Human Bone Morphogenetic Protein-2 in Spine Fusion: A Systematic Review and Meta-Analysis. Ann. Intern. Med. 2013;158:890–902, https://doi.org/10.7326/0003-4819-158-12-201306180-00006
Takemoto R, Forman J, Taormina DP, Egol KA. No Advantage to rhBMP-2 in Addition to Autogenous Graft for Fracture Nonunion. Orthopedics. 2014:37. https://doi.org/10.3928/01477447-20140528-51
Chen Y, Jia L, Han T, Zhao Z, Yang J, Xiao J, Yang H-J, Yang K. Osteoporosis Treatment: Current Drugs and Future Developments. Front. Pharmacol. 2024;15:1456796. https://doi.org/10.3389/fphar.2024.1456796
Donoso O, Pino AM, Seitz G, Osses N, Rodríguez JP. Osteoporosis‐associated Alteration in the Signalling Status of BMP‐2 in Human MSCs under Adipogenic Conditions. J Cell Biochem. 2015:116:1267-1277. https://doi.org/10.1002/jcb.25082
Akkiraju H, Bonor J, Olli K, Bowen C, Bragdon B, Coombs H, Donahue LR, Duncan R, Nohe A. Systemic Injection of CK2.3, a Novel Peptide Acting Downstream of Bone Morphogenetic Protein Receptor BMPRIa, Leads to Increased Trabecular Bone Mass. J Orthop Res. 2015;33;208-215. https://doi.org/10.1002/jor.22752
Pountos I, Georgouli T, Henshaw K, Bird H, Jones E, Giannoudis PV. The Effect of Bone Morphogenetic Protein-2, Bone Morphogenetic Protein-7, Parathyroid Hormone, and Platelet-Derived Growth Factor on the Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells Derived From Osteoporotic Bone. J Orthop Trauma. 2010;24:552-556. https://doi.org/10.1097/BOT.0b013e3181efa8fe
Prall WC, Haasters F, Heggebö J, Polzer H, Schwarz C, Gassner C, Grote S, Anz D, Jäger M, Mutschler W, et al. Mesenchymal Stem Cells from Osteoporotic Patients Feature Impaired Signal Transduction but Sustained Osteoinduction in Response to BMP-2 Stimulation. Biochem Biophys Res Commun. 2013;440:617-622. https://doi.org/10.1016/j.bbrc.2013.09.114
Garcia-Garcia P, Reyes R, Rodriguez JA, Martín T, Evora C, Díaz-Rodríguez P, Delgado A. The Bone Regeneration Capacity of BMP-2 + MMP-10 Loaded Scaffolds Depends on the Tissue Status. Pharmaceutics. 2021;13: 979. https://doi.org/10.3390/pharmaceutics13070979
Haque T, Uludag H, Zernicke RF, Winn SR, Sebald W. Bone Marrow Cells from Normal and Ovariectomized Rats Respond Differently to Basic Fibroblast Growth Factor and Bone Morphogenetic Protein 2 Treatment in Vitro. Tissue Eng. 2005;11:634-644. https://doi.org/10.1089/ten.2005.11.634
Weidner H, Yuan Gao V, Dibert D, McTague S, Eskander M, Duncan R, Wang L, Nohe A. CK2.3, a Mimetic Peptide of the BMP Type I Receptor, Increases Activity in Osteoblasts over BMP2. Int J Mol Sci. 2019;20:5877. https://doi.org/10.3390/ijms20235877
Zhao B, Xing G, Wang A. The BMP Signaling Pathway Enhances the Osteoblastic Differentiation of Bone Marrow Mesenchymal Stem Cells in Rats with Osteoporosis. J Orthop Surg. 2019;14:462. https://doi.org/10.1186/s13018-019-1512-3
Huang T-Y, Wu C-C, Weng P-W, Chen J-M, Yeh W-L. Effect of ErhBMP-2-Loaded β-Tricalcium Phosphate on Ulna Defects in the Osteoporosis Rabbit Model. Bone Rep. 2021;14:100739. https://doi.org/10.1016/j.bonr.2020.100739
Kim HJ, Kim K-H, Lee Y-M, Ku Y, Rhyu I-C, Seol Y-J. In Ovariectomy-Induced Osteoporotic Rat Models, BMP-2 Substantially Reversed an Impaired Alveolar Bone Regeneration Whereas PDGF-BB Failed. Clin Oral Investig. 2021;25:6159-6170. https://doi.org/10.1007/s00784-021-03915-7
Moon YJ, Jeong S, Lee K-B. Bone Morphogenetic Protein 2 Promotes Bone Formation in Bone Defects in Which Bone Remodeling Is Suppressed by Long-Term and High-Dose Zoledronic Acid. Bioengineering. 2023;10:86. https://doi.org/10.3390/bioengineering10010086
Liporace FA, Breitbart EA, Yoon RS, Doyle E, Paglia DN, Lin S. The Effect of Locally Delivered Recombinant Human Bone Morphogenetic Protein-2 with Hydroxyapatite/Tri-Calcium Phosphate on the Biomechanical Properties of Bone in Diabetes-Related Osteoporosis. J Orthop Traumatol. 2015;16:151-159. https://doi.org/10.1007/s10195-014-0327-6
Wu ZX, Liu D, Wan SY, Zhang Y, Lei W, Cui G. Sustained-Release rhBMP-2 Increased Bone Mass and Bone Strength in an Ovine Model of Postmenopausal Osteoporosis. J Orthop Sci. 2011;16:99-104. https://doi.org/10.1007/s00776-010-0019-x
Jing D, Hao X, Xu F, Liu J, Xu F, Luo E, Meng G. Effects of Local Delivery of BMP2, Zoledronate and Their Combination on Bone Microarchitecture, Biomechanics and Bone Turnover in Osteoporotic Rabbits. Sci Rep. 2016;6:28537. https://doi.org/10.1038/srep28537
Chen X, Wang S, Zhang X, Yu Y, Wang J, Liu C. Dual-Function Injectable Fibrin Gel Incorporated with Sulfated Chitosan Nanoparticles for rhBMP-2-Induced Bone Regeneration. Appl Mater Today. 2022;26: 101347. https://doi.org/10.1016/j.apmt.2021.101347
Echave MC, Erezuma I, Golafshan N, Castilho M, Kadumudi F.B, Pimenta-Lopes C, Ventura F, Pujol A, Jimenez JJ, Camara JA, et al. Bioinspired Gelatin/Bioceramic Composites Loaded with Bone Morphogenetic Protein-2 (BMP-2) Promote Osteoporotic Bone Repair. Biomater Adv. 2022;134: 112539. https://doi.org/10.1016/j.msec.2021.112539
Lee JH, Baek H-R, Lee K-M, Zheng GB, Shin SJ, Shim H-J. Effects of Ovariectomy and Corticosteroid-Induced Osteoporosis on the Osteoinductivity of rhBMP-2 in a Segmental Long-Bone Defect Model. Tissue Eng. Part A. 2015;21:2262-2271. https://doi.org/10.1089/ten.tea.2014.0659
Van Houdt CIA, Koolen MKE, Lopez‐Perez PM, Ulrich DJO, Jansen JA, Leeuwenburgh SCG, Weinans HH, Van Den Beucken JJJP. Regenerating Critical Size Rat Segmental Bone Defects with a Self‐Healing Hybrid Nanocomposite Hydrogel: Effect of Bone Condition and BMP‐2 Incorporation. Macromol Biosci. 2021;21:2100088. https://doi.org/10.1002/mabi.202100088
Ouyang X, Ding Y, Yu L, Xin F, Yang X, Sha P, Tong S, Cheng Q, Xu Y. Effects of BMP-2 Compound with Fibrin on Osteoporotic Vertebral Fracture Healing in Rats. Journal of musculoskeletal & neuronal interactions. 2021; 149-156.
Park SB, Park SH, Kim N-H, Chung CK. BMP-2 Induced Early Bone Formation in Spine Fusion Using Rat Ovariectomy Osteoporosis Model. Spine J. 2013;13:1273-1280. https://doi.org/10.1016/j.spinee.2013.06.010
Sarban S, Senkoylu A, Isikan UE, Korkusuz P, Korkusuz F. Can rhBMP-2 Containing Collagen Sponges Enhance Bone Repair in Ovariectomized Rats?: A Preliminary Study. Clin Orthop Relat Res. 2009;467:3113-3120. https://doi.org/10.1007/s11999-009-1004-6
Tao Z, Zhou W, Jiang Y, Wu X, Xu Z, Yang M, Xie J. Effects of Strontium-Modified Calcium Phosphate Cement Combined with Bone Morphogenetic Protein-2 on Osteoporotic Bone Defects Healing in Rats. J Biomater Appl. 2018;33:3-10, https://doi.org/10.1177/0885328218765847
Song Y, Wan L, Zhang S, DuY. Biological Response to Recombinant Human Bone Morphogenetic Protein-2 on Bone-Implant Osseointegration in Ovariectomized Experimental Design. J Craniofac Surg. 2019;30:141-144. https://doi.org/10.1097/SCS.0000000000004992
Ghodasra JH, Nickoli MS, Hashmi SZ, Nelson JT, Mendoza M, Nicolas JD, Bellary SS, Sonn K Ashtekar A, Park CJ, et al. Ovariectomy-Induced Osteoporosis Does Not Impact Fusion Rates in a Recombinant Human Bone Morphogenetic Protein-2–Dependent Rat Posterolateral Arthrodesis Model. Glob Spine J. 2016;6:60-68. https://doi.org/10.1055/s-0035-1556582
Li M, Liu X, Liu X, Ge B. Calcium Phosphate Cement with BMP-2-Loaded Gelatin Microspheres Enhances Bone Healing in Osteoporosis: A Pilot Study. Clin Orthop. 2010;468:1978-1985. https://doi.org/10.1007/s11999-010-1321-9
Zarrinkalam MR, Schultz CG, Ardern DW, Vernon‐Roberts B, Moore RJ. Recombinant Human Bone Morphogenetic Protein‐type 2 (rhBMP‐2) Enhances Local Bone Formation in the Lumbar Spine of Osteoporotic Sheep. J Orthop Res. 2013;31:1390-1397. https://doi.org/10.1002/jor.22387
Kim S-H, Park Y, Shin J-W, Ha J-W, Choi H-M, Kim H.-S, Moon S-H, Suk K-S, Park S-Y, Lee B-H, et al. Accelerated Fusion Dynamics by Recombinant Human Bone Morphogenetic Protein-2 Following Transforaminal Lumbar Interbody Fusion, Particularly in Osteoporotic Conditions. Spine J. 2024;24:2078-2085. https://doi.org/10.1016/j.spinee.2024.06.010
Lee K-B, Johnson JS, Song K-J, Taghavi CE, Wang JC. Use of Autogenous Bone Graft Compared With RhBMP in High-Risk Patients: A Comparison of Fusion Rates and Time to Fusion. J Spinal Disord Tech. 2013;26:233-238. https://doi.org/10.1097/BSD.0b013e3182440162
Xia Y-D, Zhang R, Liu Q, Chen J-R. Application value of bone cement containing rhbFGF and RHBMP-2 in PKP treatment of osteoporotic lumbar compression fracture. Zhongguo Gu Shang China J Orthop Traumatol. 2024; 37:15-20. https://doi.org/10.12200/j.issn.1003-0034.20221048
Cicciù M, Herford AS, Juodžbalys G, Stoffella E. Recombinant Human Bone Morphogenetic Protein Type 2 Application for a Possible Treatment of Bisphosphonates-Related Osteonecrosis of the Jaw: J Craniofac Surg. 2012;23:784-788. https://doi.org/10.1097/SCS.0b013e31824dbdd4
Ku J-K, Choi J-W, Song S-M, Yun P-Y, Um I-W, Leem DH. Demineralized Dentin Matrix Incorporated with rhBMP-2 Composite Graft for Treating Medication-Related Osteonecrosis of the Jaw. J Clin Med. 2024;13:4830. https://doi.org/10.3390/jcm13164830
Lee K-B, Taghavi CE, Hsu MS, Song K-J, Yoo JH, Keorochana G, Ngo SS, Wang JC. The Efficacy of rhBMP-2 versus Autograft for Posterolateral Lumbar Spine Fusion in Elderly Patients. Eur Spine J. 2010;19:924–930. https://doi.org/10.1007/s00586-009-1248-6
Ryu S, Yoon S-J, Lee CK, Yi S, Kim K-N, Ha Y, Shin DA. The Combined Effects of RhBMP-2 and Systemic RANKL Inhibitor in Patients With Bone Density Loss Undergoing Posterior Lumbar Interbody Fusion: A Retrospective Observational Analysis With Propensity Score Matching. Neurospine 2023;20:1186-1192. https://doi.org/10.14245/ns.2346702.351
James AW, LaChaud G, Shen J, Asatrian G, Nguyen V, Zhang X, Ting K, Soo C. A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2. Tissue Eng Part B Rev. 2016;22:284-297. https://doi.org/10.1089/ten.teb.2015.0357
Zara JN, Siu RK, Zhang X, Shen J, Ngo R, Lee M, Li W, Chiang M, Chung J, Kwak J, et al. High Doses of Bone Morphogenetic Protein 2 Induce Structurally Abnormal Bone and Inflammation In Vivo. Tissue Eng Part A. 2011;17:1389-1399. https://doi.org/10.1089/ten.tea.2010.0555
Ryu S, Yoon S-J, Lee CK, Yi S, Kim K-N, Ha Y, Shin DA. The Combined Effects of RhBMP-2 and Systemic RANKL Inhibitor in Patients With Bone Density Loss Undergoing Posterior Lumbar Interbody Fusion: A Retrospective Observational Analysis With Propensity Score Matching. Neurospine. 2023;20:1186–1192. https://doi.org/10.14245/ns.2346702.351