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Doroshchuk N.A.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Postnov A.Yu.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Doroshchuk A.D.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Khasanova Z.B.

FGBOU VPO "Kabardino-Balkarskiĭ gosudarstvennyĭ universitet im. Kh.M. Berbekova" Ministerstva obrazovaniia i nauki Rossii, Nal'chik

Konovalova N.V.

«Sintol» Closed Joint-Stock Company, Moscow, Russia, 127550

Khesuani Iu.D.

NII klinicheskoĭ kardiologii im. A.L. Miasnikova FGBU "Rossiĭskiĭ kardiologicheskiĭ nauchno-proizvodstvennyĭ kompleks" Minzdrava Rossii, Moskva

Osiaeva M.K.

NII klinicheskoĭ kardiologii im. A.L. Miasnikova FGBU "Rossiĭskiĭ kardiologicheskiĭ nauchno-proizvodstvennyĭ kompleks" Minzdrava Rossii, Moskva

Rodnenkov O.V.

Federal State budget organization «National medical research center of cardiology» of the Ministry of healthcare of the Russian Federation, Moscow, Russia

Chazova I.E.

Federal State budget organization National Medical Research Center of Cardiology of the Ministry of healthcare of the Russian Federation, The Institute of Clinical Cardiology, Moscow, Russia

Direct human DNA damage by unfavorable environmental and climatic factors

Authors:

Doroshchuk N.A., Postnov A.Yu., Doroshchuk A.D., Khasanova Z.B., Konovalova N.V., Khesuani Iu.D., Osiaeva M.K., Rodnenkov O.V., Chazova I.E.

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Journal: Therapeutic Archive. 2014;86(12): 72‑77

DOI: 10.17116/terarkh2014861272-77

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DIRECT HUMAN DNA DAMAGE BY UNFAVORABLE ENVIRONMENTAL AND CLIMATIC FACTORS
DIRECT HUMAN DNA DAMAGE BY UNFAVORABLE ENVIRONMENTAL AND CLIMATIC FACTORS

To cite this article:

Doroshchuk NA, Postnov AYu, Doroshchuk AD, et al. . Direct human DNA damage by unfavorable environmental and climatic factors. Therapeutic Archive. 2014;86(12):72‑77. (In Russ.)
https://doi.org/10.17116/terarkh2014861272-77

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Abstract:

Aim. To study the impact of simulated climatic conditions of the 2010 summer in Moscow on the telomere repeats of chromosomes in human blood cells. Materials and methods. The climatic conditions of July-August 2010 in Moscow were simulated at the Medical Technical Complex, Institute of Biomedical Problems, Russian Academy of Sciences. The relative length of the telomeric repeats of blood cell chromosomes from 6 apparently healthy volunteers was measured by quantitative real-time polymerase chain reaction. Results. These conditions were ascertained to lead to a statistically significant decline in the length of telomere repeats in the terminal portions of chromosomes by 15%. Conclusion. Environmental changes and abnormal temperature rises may result in oxidative stress accompanied by telomere shortening, which can be, in turn, a factor of premature aging.

Keywords:

telomere repeat length
DNA
carbon monoxide
hyperthermia
oxidative stress

Authors:

Doroshchuk N.A.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Postnov A.Yu.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Doroshchuk A.D.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Khasanova Z.B.

FGBOU VPO "Kabardino-Balkarskiĭ gosudarstvennyĭ universitet im. Kh.M. Berbekova" Ministerstva obrazovaniia i nauki Rossii, Nal'chik

Konovalova N.V.

«Sintol» Closed Joint-Stock Company, Moscow, Russia, 127550

Khesuani Iu.D.

NII klinicheskoĭ kardiologii im. A.L. Miasnikova FGBU "Rossiĭskiĭ kardiologicheskiĭ nauchno-proizvodstvennyĭ kompleks" Minzdrava Rossii, Moskva

Osiaeva M.K.

NII klinicheskoĭ kardiologii im. A.L. Miasnikova FGBU "Rossiĭskiĭ kardiologicheskiĭ nauchno-proizvodstvennyĭ kompleks" Minzdrava Rossii, Moskva

Rodnenkov O.V.

Federal State budget organization «National medical research center of cardiology» of the Ministry of healthcare of the Russian Federation, Moscow, Russia

Chazova I.E.

Federal State budget organization National Medical Research Center of Cardiology of the Ministry of healthcare of the Russian Federation, The Institute of Clinical Cardiology, Moscow, Russia

Close metadata

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