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Shai A.N.

Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Russian Ministry of Health, Moscow, Russia, 125284

Fedulova M.V.

FBGU"Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii

Kvacheva Iu.E.

Laboratoriia radiatsionnoĭ klinicheskoĭ patomorfologii Federal'nogo meditsinskogo biofizicheskogo tsentra im. A.I. Burnaziana

Shigeev S.V.

FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdrava Rossii

Kovalev A.V.

Krasnojarskij filial FGBU «Gematologicheskij nauchnyj tsentr» Minzdrava Rossii

The importance of marker proteins of the nervous tissue for morphological diagnostics of the craniocerebral injury

Authors:

Shai A.N., Fedulova M.V., Kvacheva Iu.E., Shigeev S.V., Kovalev A.V.

More about the authors

Journal: Forensic Medical Expertise. 2017;60(4): 40‑45

DOI: 10.17116/sudmed201760440-45

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Table of contents

THE IMPORTANCE OF MARKER PROTEINS OF THE NERVOUS TISSUE FOR MORPHOLOGICAL DIAGNOSTICS OF THE CRANIOCEREBRAL INJURY
THE IMPORTANCE OF MARKER PROTEINS OF THE NERVOUS TISSUE FOR MORPHOLOGICAL DIAGNOSTICS OF THE CRANIOCEREBRAL INJURY

To cite this article:

Shai AN, Fedulova MV, Kvacheva IuE, Shigeev SV, Kovalev AV. The importance of marker proteins of the nervous tissue for morphological diagnostics of the craniocerebral injury. Forensic Medical Expertise. 2017;60(4):40‑45. (In Russ.)
https://doi.org/10.17116/sudmed201760440-45

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The present review of the literature involves 50 publications concerning various substrates of importance as the biological markers of axonal damages with special reference to the secondary molecular and cellular mechanisms on which to base in vitro and in vivo modeling of the craniocerebral injury. The results of the investigations with the application of mass-spectrometry for the identification of the proteins specifically synthesized in response to the injury are presented; their biological functions are described. The use of the sequential microscopic imaging technique and the immunohistochemical methods made it possible to determine that the majority of the marker proteins are involved in the specific intracellular processes that are triggered in response to the traumatic impact including apoptosis, proliferation, formation of lamellipodia, axon regeneration, actin remodeling, cell migration and inflammation. In addition, a rise in the amount of intracellular actin-associated proteins has been observed. It is concluded that the investigations into the properties and the physiological role of beta-amyloid precursor protein (beta-APP) are of special value for the characteristic of nervous tissue damages and morphological diagnostics of the craniocerebral injury.

Keywords:

morphological diagnostics of the craniocerebral injury
diffuse axonal damage
beta-APP
immunohistochemical studies
biological markers

Authors:

Shai A.N.

Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Russian Ministry of Health, Moscow, Russia, 125284

Fedulova M.V.

FBGU"Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii

Kvacheva Iu.E.

Laboratoriia radiatsionnoĭ klinicheskoĭ patomorfologii Federal'nogo meditsinskogo biofizicheskogo tsentra im. A.I. Burnaziana

Shigeev S.V.

FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdrava Rossii

Kovalev A.V.

Krasnojarskij filial FGBU «Gematologicheskij nauchnyj tsentr» Minzdrava Rossii

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