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Shai A.N.

Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Russian Ministry of Health, Moscow, Russia, 125284

Fedulova M.V.

FBGU"Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii

Kvacheva Iu.E.

Laboratoriia radiatsionnoĭ klinicheskoĭ patomorfologii Federal'nogo meditsinskogo biofizicheskogo tsentra im. A.I. Burnaziana

Shigeev S.V.

FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdrava Rossii

Kovalev A.V.

Krasnojarskij filial FGBU «Gematologicheskij nauchnyj tsentr» Minzdrava Rossii

The importance of marker proteins of the nervous tissue for morphological diagnostics of the craniocerebral injury

Authors:

Shai A.N., Fedulova M.V., Kvacheva Iu.E., Shigeev S.V., Kovalev A.V.

More about the authors

Journal: Forensic Medical Expertise. 2017;60(4): 40‑45

DOI: 10.17116/sudmed201760440-45

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Table of contents

THE IMPORTANCE OF MARKER PROTEINS OF THE NERVOUS TISSUE FOR MORPHOLOGICAL DIAGNOSTICS OF THE CRANIOCEREBRAL INJURY
THE IMPORTANCE OF MARKER PROTEINS OF THE NERVOUS TISSUE FOR MORPHOLOGICAL DIAGNOSTICS OF THE CRANIOCEREBRAL INJURY

To cite this article:

Shai AN, Fedulova MV, Kvacheva IuE, Shigeev SV, Kovalev AV. The importance of marker proteins of the nervous tissue for morphological diagnostics of the craniocerebral injury. Forensic Medical Expertise. 2017;60(4):40‑45. (In Russ.)
https://doi.org/10.17116/sudmed201760440-45

Подписка 2025-2 (Forensic Medical Expertise)
 
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The present review of the literature involves 50 publications concerning various substrates of importance as the biological markers of axonal damages with special reference to the secondary molecular and cellular mechanisms on which to base in vitro and in vivo modeling of the craniocerebral injury. The results of the investigations with the application of mass-spectrometry for the identification of the proteins specifically synthesized in response to the injury are presented; their biological functions are described. The use of the sequential microscopic imaging technique and the immunohistochemical methods made it possible to determine that the majority of the marker proteins are involved in the specific intracellular processes that are triggered in response to the traumatic impact including apoptosis, proliferation, formation of lamellipodia, axon regeneration, actin remodeling, cell migration and inflammation. In addition, a rise in the amount of intracellular actin-associated proteins has been observed. It is concluded that the investigations into the properties and the physiological role of beta-amyloid precursor protein (beta-APP) are of special value for the characteristic of nervous tissue damages and morphological diagnostics of the craniocerebral injury.

Keywords:

morphological diagnostics of the craniocerebral injury
diffuse axonal damage
beta-APP
immunohistochemical studies
biological markers

Authors:

Shai A.N.

Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Russian Ministry of Health, Moscow, Russia, 125284

Fedulova M.V.

FBGU"Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii

Kvacheva Iu.E.

Laboratoriia radiatsionnoĭ klinicheskoĭ patomorfologii Federal'nogo meditsinskogo biofizicheskogo tsentra im. A.I. Burnaziana

Shigeev S.V.

FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdrava Rossii

Kovalev A.V.

Krasnojarskij filial FGBU «Gematologicheskij nauchnyj tsentr» Minzdrava Rossii

List of references:

  1. Chytrova G, Ying Z, Gomez-Pinilla F. Exercise normalizes levels of MAG and Nogo-A growth inhibitors after brain trauma. European Lournal of Neurosciece. 2008;27:1-11.
  2. Namjoshi DR, Cheng WH, McInnes KA, Martens KM, Carr M, Wilkinson A, Fan J, Robert J, Hayat A, Cripton PA, Wellington CL. Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel, surgery-free model of traumatic brain injury. Mol Neurodegener. 2014 Dec 1;9:55. https://doi.org/10.1186/1750-1326-9-55
  3. Bazarian JJ, Zemlan FP, Mookerjee S, Stigbrand T. Serum S-100B and cleaved-tau arepoor predictors of long-term outcome after mild traumatic braininjury. Brain Inj. 2006 Jun;20(7):759-765.
  4. Gyoneva S, Kim D, Katsumoto A, Kokiko-Cochran ON, Lamb BT, Ransohoff RM. Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury. Neuroinflammation. 2015 Dec 3;12:228. https://doi.org./10.1186/s12974-015-0443-0
  5. Ahmadzadeh H, Smith DH, Shenoy VB, Biophys J. Viscoelasticity of tau proteins leads to strain rate-dependent breaking of microtubules during axonal stretch injury: predictions from a mathematical model. 2014 Mar 4; 106(5):1123-1133. https://doi.org/10.1016/j.bpj.2014.01.024
  6. Zurek J, Bartlová L, Fedora M. Hyperphosphorylated neurofilament NF-H as a predictor of mortality after brain injury in children. Brain Inj. 2011;25(2):221-226. https://doi.org/10.3109/02699052.2010.541895
  7. Hayakawa K, Okazaki R, Ishii K, Ueno T, Izawa N, Tanaka Y, Toyooka S, Matsuoka N, Morioka K, Ohori Y, Nakamura K, Akai M, Tobimatsu Y, Hamabe Y, Ogata T. Phosphorylated neurofilament subunit NF-H as a biomarker for evaluating the severity of spinal cord injury patients, a pilot study. Spinal Cord. 2012 Jul;50(7):493-496. https://doi.org/10.1038/sc.2011.184
  8. Lafrenaye AD, Todani M, Walker SA, Povlishock JT. Microglia processes assiciate with diffusely injuredaxons following mild traumatic brain injury in the micro pig. J Neuroinflammation. 2015 Oct 6;12:186. https://doi.org/10.1186/s12974-015-0405-6
  9. Bennett RE, Brody DL. Acute reduction of microglia does not alter axonal injury in a mouse model of repetitive concussive traumatic brain injury. J Neurotrauma. 2014 Oct 1;31(19):1647-1663. https://doi.org/10.1089/neu.2013.3320
  10. Wishart TM. Combining Comparative Proteotomics and Molecular Genetics Uncovera Regulators of Synaotic and Axonal Stability and Degeneration In Vivo. PLOS Genetics. 2012;8(8):e1002936.
  11. Barzdina A, Pilmane M, Petersons A. GFAP and expression in brain tissue in children and adults after fatal traumatic brain injury. Papers on Anthropology XX. 2011;51-62.
  12. Morrison B, Elkin BS, Dollé JP, Yarmush ML. In vitro models of traumatic brain injury. Annu Rev Biomed Eng. 2011 Aug 15;13:91-126. https://doi.org/10.1146/annurev-bioeng-071910-124706
  13. Kumaria A, Tolias CM. In vitro models of neurotrauma. Br J Neurosurg. 2008 Apr;22(2):200-206. https://doi.org/10.1080/02688690701772413
  14. Loov C, Hillered L, Ebendal T, Erlandsson A. Engulfing astrocytes protect neurons from contact-induced apoptosis following injury. PLoS One. 2012;7(3):e33090. https://doi.org/10.1371/journal.pone.0033090
  15. Loov C, Shevchenko G, Nadadhur AG. Identification of injury specific proteins in a cell culture model of traumatic. Brain injury. 2013;8(2):e55983.
  16. Ravin R, Hoeppner DJ, Munno DM, Carmel L, Sullivan J, Levitt DL, Miller JL, Athaide C, Panchision DM, McKay RD. Potency and fate specification in CNS stem cell populations in vitro. Cell Stem Cell. 2008 Dec 4;3(6):670-680. https://doi.org/10.1016/j.stem.2008.09.012
  17. Sokolowski JD, Gamage KK, Heffron DS, Leblanc AC, Deppmann CD, Mandell JW. Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury. Acta Neuropathol Commun. 2014 Feb 7;2:16. https://doi.org/10.1186/2051-5960-2-16
  18. Moon Y, Kim JY, Choi SY, Kim K, Kim H, Sun W. Induction of ezrin-radixin-moesin molecules after cryogenic traumatic brain injury of the mouse cortex. Neuroreport. 2011 Apr 20;22(6):304-308. https://doi.org/10.1097/WNR.0b013e3283460265
  19. Lee SH, Dominguez R. Regulation of actin cytoskeleton dynamics in cells. Mol Cells. 2010 Apr;29(4):311-325.
  20. Wright KT, Seabright R, Logan A, Lilly AJ, Khanim F, Bunce CM, Johnson WE. Extracellular Nm23H1 stimulates neurite outgrowth from dorsal root ganglia neurons in vitro independently of nerve growth factor supplementation or its nucleoside diphosphate kinase activity. Biochem Biophys Res Commun. 2010 Jul 16;398(1):79-85. https://doi.org/10.1016/j.bbrc.2010.06.039
  21. Yamaguchi H, Shiraishi M, Fukami K, Tanabe A, Ikeda-Matsuo Y, Naito Y, Sasaki Y. MARCKS regulates lamellipodia formation induced by IGF-I via association with PIP2 and beta-actin at membrane microdomains. J Cell Physiol. 2009 Sep;220(3):748-755. https://doi.org/10.1002/jcp.21822
  22. Korobova F, Svitkina T. Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cells. Mol Biol Cell. 2008 Apr;19(4):1561-1574. https://doi.org/10.1091/mbc.E07-09-0964
  23. Wojciak-Stothard B, Torondel B, Tsang LY, Fleming I, Fisslthaler B, Leiper JM, Vallance P. The ADMA/DDAH pathway is a critical regulator of endothelial cell motility. J Cell Sci. 2007 Mar 15;120(Pt 6):929-942. Epub 2007 Feb 27. Erratum in: J Cell Sci. 2007 Apr 15;120(Pt 8):1502.
  24. Fiedler LR, Wojciak-Stothard B. The DDAH/ADMA pathway in the control of endothelial cell migration and angiogenesis. Biochem Soc Trans. 2009 Dec;37(Pt 6):1243-1247. https://doi.org/10.1042/BST0371243
  25. Qi YX, Qu MJ, Long DK, Liu B, Yao QP, Chien S, Jiang Z.L. Rho-GDP dissociation inhibitor alpha downregulated by low shear stress promotes vascular smooth muscle cell migrationand apoptosis: a proteomic analysis. Cardiovasc Res. 2008 Oct 1;80(1):114-122. https://doi.org/10.1093/cvr/cvn158
  26. Chianale F, Rainero E, Cianflone C, Bettio V, Pighini A, Porporato PE, Filigheddu N, Serini G, Sinigaglia F, Baldanzi G, Graziani A. Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. Proc Natl Acad Sci USA. 2010 Mar 2;107(9):4182-4187. https://doi.org/10.1073/pnas.0908326107
  27. Hoffman-Kim D, Mitchel JA, Bellamkonda RV. Topography, cell response, and nerve regeneration. Annu Rev Biomed Eng. 2010 Aug 15;12:203-231. https://doi.org/10.1146/annurev-bioeng-070909-105351
  28. Chen XQ, Fung YW, Yu AC. Association of 14-3-gamma and phosphorylated bad ttenuates injury in ischemic astrocytes. J Cereb Blood Flow Metab. 2005 Mar;25(3):338-347.
  29. Maas AI, Stocchetti N, Bullock R. Moderate and severe traumatic brain injury in adults. Lancet Neurol. 2008 Aug;7(8):728-741. https://doi.org/10.1016/S1474-4422(08)70164-9
  30. Helmy A, De Simoni MG, Guilfoyle MR, Carpenter KL, Hutchinson PJ. Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury. Prog Neurobiol. 2011 Nov;95(3):352-372. https://doi.org/10.1016/j.pneurobio.2011.09.003
  31. Marion S, Hoffmann E, Holzer D, Le Clainche C, Martin M, Sachse M, Ganeva I, Mangeat P, Griffiths G. Ezrin promotes actin assembly at the phagosome membrane and regulates phago-lysosomal fusion. Traffic. 2011 Apr;12(4):421-437. https://doi.org/10.1111/j.1600-0854.2011.01158.x
  32. Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S. LAMP proteins are required for fusion of lysosomes with phagosomes. EMBO J. 2007 Jan 24;26(2):313-324. 
  33. Castoreno AB, Wang Y, Stockinger W, Jarzylo LA, Du H, Pagnon JC, Shieh EC, Nohturfft A. Transcriptional regulation of phagocytosis- induced membrane biogenesis by sterol regulatory element binding proteins. Proc Natl Acad Sci USA. 2005 Sep 13;102(37):13129-13134.
  34. Groves E, Dart AE, Covarelli V, Caron E. Molecular mechanisms of phagocytic uptake in mammalian cells. Cell Mol Life Sci. 2008 Jul;65(13):1957-1976. https://doi.org/10.1007/s00018-008-7578-4
  35. Peri F, Nüsslein-Volhard C. Live imaging of neuronal degradation by microglia reveals a role for v0-ATPase a1 in phagosomal fusion in vivo. Cell. 2008 May 30;133(5):916-927. https://doi.org/10.1016/j.cell.2008.04.037
  36. Chastain EM, Duncan DS, Rodgers JM, Miller SD. The role of antigen presenting cells in multiple sclerosis. Biochim Biophys Acta. 2011 Feb;1812(2):265-274. https://doi.org/10.1016/j.bbadis.2010.07.008
  37. Moalem G, Monsonego A, Shani Y, Cohen IR, Schwartz M. Differential T cell response in central and peripheral nerve injury: connection with immune privilege. FASEB J. 1999 Jul;13(10):1207-1217.
  38. Wolk K, Grütz G, Witte K, Volk HD, Sabat R. The expression of legumain, an asparaginyl endopeptidase that controls antigen processing, is reduced in endotoxin-tolerantmonocytes. Genes Immun. 2005 Aug;6(5):452-456.
  39. Zhang W, Wearsch PA, Zhu Y, Leonhardt RM, Cresswell P. A role for UDP-glucose glycoprotein glucosyltransferase in expression and quality control of MHC class I molecules. Proc Natl Acad Sci USA. 2011 Mar 22;108(12):4956-4961. https://doi.org/10.1073/pnas.1102527108
  40. Riddell JR, Wang XY, Minderman H, Gollnick SO. Peroxiredoxin 1 stimulates secretion of proinflammatory cytokines by binding to TLR4. J Immunol. 2010 Jan 15;184(2):1022-1030. https://doi.org/10.4049/jimmunol.0901945
  41. Clausen F, Lorant T, Lewén A, Hillered L. T lymphocyte trafficking: a novel target for neuroprotection in traumatic brain injury. J Neurotrauma. 2007 Aug;24(8):1295-1307.
  42. Kreipke CW, Morgan NC, Petrov T, Rafols JA. Calponin and caldesmon cellular domains in reacting microvessels following traumatic brain injury. Microvasc Res. 2006 May;71(3):197-204.
  43. Campbell JN, Low B, Kurz JE, Patel SS, Young MT, Churn SB. Mechanisms of dendritic spine remodeling in a rat model of traumatic brain injury. J Neurotrauma. 2012 Jan 20;29(2):218-234. https://doi.org/10.1089/neu.2011.1762
  44. Sukhorukova EG. Strukturnaya organizatsiya astrotsitov neokorteksa krysy i cheloveka, soderzhashchikh glial’nyi fibrillyarnyi kislyi belok: Dis. … kand. med. nauk. SPb. 2011. (In Russ.) .
  45. Sukhorukova EG, Korzhevsky DE, Kirik OV, Korzhevskaya VF. Immunohistochemical detection of brain astrocytes in traumatic brain injury. Sudebno-meditzinskaya expertiza. 2010;53(1):14-16. (In Russ.) .
  46. Tsukanova AF, Monid MV, Naumov NG, Droblenkov AV. Early changes in reactive astrocytes after brain injury. Astrakhanskiy medicinskiy journal. 2013;8(1):288-291. (In Russ.) .
  47. Secreted Amyloid Precursor Protein β and Secreted Amyloid Precursor α Induce Axon Outgrowth In Vitro through Egr1 Signaling Pathway. PLos ONE. 2011;6(1):1-10.
  48. Traumatic axonal damage in the brain can be detected using beta-APP immunohistochemestri within 35 min after head injury to human adults. Neuropathol Appl Neurobiol. 2007 Apr;33(2):226-237.
  49. Axonal Injury in Young Pediatric Head Trauma: A Comparison Study of β-amyloid Precursor Protein (β-APP) Immunohistochemical Staining in Traumatic and Nontraumatic Deaths. J. Forensic Sci. 2011 September;56(5):1198-1205.
  50. Jensen LL, Banner J, Uihoi ВР. B-amyloid Precursor Protein Staining Of The Brain in Sudden Infant and Early Childhood Death. Neuropathology and Applied Neurobiology. 2014;40(4):385-397. https://doi.org/10.1111/nan.12109

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