The aim. To identify the leading pathogenetic factors of dental caries in children with celiac disease. Material and methods. The study included 48 children with a confirmed diagnosis of celiac disease at the age of 8—16 years. All the children were examined by a dentist, the oral cavity was sanitized, recommendations for oral care were given. All children followed a gluten-free diet and brushed their teeth at least once a day. The control group consisted of children (27 people) at the same age who did not have celiac disease. It was found that children with celiac disease have high rates of dental caries in comparison with children without this disease. Results and conclusion. The leading pathogenetic factors affecting the hard tissues of the teeth is a lack of vitamin D, a high titer of Streptococcus mutans in saliva and a low salivation rate.