Changes in proinflammatory cytokines in patients with chronic periodontitis and metabolic syndrome, depending on gender and age

Petrukhina N.B.

Kafedra stomatologii FPPOV GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava RF

Zorina O.A.

GBOU VPO "Pervyĭ MGMU imeni I.M. Sechenova"

Shikh E.V.

Kafedra klinicheskoĭ farmakologii i propedevtiki vnutrennikh bolezneĭ GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova"

Kartysheva E.V.

I.M. Sechenov First Moscow State Medical University, Moscow, Russia

Kudryavtsev A.V.

Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia

Berkutova I.S.

GBOU VPO "Pervyĭ MGMU imeni I.M. Sechenova"

Changes in proinflammatory cytokines in patients with chronic periodontitis and metabolic syndrome, depending on gender and age

Authors:

Petrukhina N.B., Zorina O.A., Shikh E.V., Kartysheva E.V., Kudryavtsev A.V., Berkutova I.S.

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Journal: Stomatology. 2018;97(6): 38‑44

DOI: 10.17116/stomat20189706138

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To cite this article:

Petrukhina NB, Zorina OA, Shikh EV, Kartysheva EV, Kudryavtsev AV, Berkutova IS. Changes in proinflammatory cytokines in patients with chronic periodontitis and metabolic syndrome, depending on gender and age. Stomatology. 2018;97(6):38‑44. (In Russ.)
https://doi.org/10.17116/stomat20189706138

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In a study of 537 patients with chronic generalized periodontitis and metabolic syndrome (MS) depending on age and gender, it was found that the increase of TNF-α and IL-6 in the content of periodontal pockets correlated with the severity of chronic generalized periodontitis and MS. For these cytokines, there was a clear gender relationship: women had higher levels in periodontal pocket content than men. For IL-1β and IL-4 cytokines, there is no coupling between the severity of the damage and the level of cytokines in the periodontal pocket. The developed model for calculating the risk of chronic generalized periodontitis depending on the level of TNF-α in the patient’s periodontal pockets allows predicting and monitoring the dynamics of the disease.

Keywords:

chronic generalized periodontitis

metabolic syndrome

cytokines

gender

tumor necrosis factor

TNF

Authors:

Petrukhina N.B.

Kafedra stomatologii FPPOV GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava RF

Zorina O.A.

GBOU VPO "Pervyĭ MGMU imeni I.M. Sechenova"

Shikh E.V.

Kafedra klinicheskoĭ farmakologii i propedevtiki vnutrennikh bolezneĭ GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova"

Kartysheva E.V.

I.M. Sechenov First Moscow State Medical University, Moscow, Russia

Kudryavtsev A.V.

Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia

Berkutova I.S.

GBOU VPO "Pervyĭ MGMU imeni I.M. Sechenova"

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