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Babichenko I.I.

Russian University of People’s Friendship, Moscow, Russia, 117198

Tsimbalist N.S.

Department of Pathological Anatomy, People’s Friendship University of Russia, Moscow, Russia

Rybalskaya V.F.

Department of Pathological Anatomy, People’s Friendship University of Russia, Moscow, Russia

Sherstnev A.A.

Peoples’ Friendship University of Russia, Moscow, Russia, 117198

Semkin V.A.

Otdelenie khirurgicheskoĭ stomatologii FGBU "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii" Minzdrava RF, Moskva

The role of Wnt/β-catenin signaling pathway in ameloblastoma formation

Authors:

Babichenko I.I., Tsimbalist N.S., Rybalskaya V.F., Sherstnev A.A., Semkin V.A.

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Journal: Stomatology. 2018;97(2): 22‑24

DOI: 10.17116/stomat201897222-24

Views: 572

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THE ROLE OF WNT/Β-CATENIN SIGNALING PATHWAY IN AMELOBLASTOMA FORMATION
THE ROLE OF WNT/Β-CATENIN SIGNALING PATHWAY IN AMELOBLASTOMA FORMATION

To cite this article:

Babichenko II, Tsimbalist NS, Rybalskaya VF, Sherstnev AA, Semkin VA. The role of Wnt/β-catenin signaling pathway in ameloblastoma formation. Stomatology. 2018;97(2):22‑24. (In Russ.)
https://doi.org/10.17116/stomat201897222-24

Подписка 2025-2 (Stomatology)
 
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The aim of the study was to assess the role of the canonical Wnt/β-catenin signaling pathway in the formation and clinical course of various histological variants of ameloblastoma. Materials and methods: 76 cases of ameloblastoma were investigated, the average age of the patients was 46 years. There were 49 (64.5%) cases of recurrence of the disease. Tissue antigens were determined using monoclonal rabbit antibodies to Ki-67 and β-catenin. Results: it was found correlation between the proliferative activity of ameloblastoma cells and the intranuclear localization of β-catenin, indicating the activation of the Wnt/β-catenin-signaling pathway. It was shown that the nuclear localization of β-catenin is positively correlated with the recurrence. Conclusion: The Wnt/β-catenin signaling pathway is involved in a formation and progression of ameloblastoma.

Keywords:

immunohistochemistry
ameloblastoma
Ki-67
Wnt/β-catenin signaling pathway

Authors:

Babichenko I.I.

Russian University of People’s Friendship, Moscow, Russia, 117198

Tsimbalist N.S.

Department of Pathological Anatomy, People’s Friendship University of Russia, Moscow, Russia

Rybalskaya V.F.

Department of Pathological Anatomy, People’s Friendship University of Russia, Moscow, Russia

Sherstnev A.A.

Peoples’ Friendship University of Russia, Moscow, Russia, 117198

Semkin V.A.

Otdelenie khirurgicheskoĭ stomatologii FGBU "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii" Minzdrava RF, Moskva

List of references:

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  2. Wright JM, Vered M. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odontogenic and Maxillofacial Bone Tumors. Head and Neck Pathol. 2017;11(1):68-77. https://doi.org/10.1007/s12105-017-0794-1
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  4. Shaikhi Kh, Neiders M, Frank Chen F, Aguirre A. Morphological Variants of Ameloblastoma and Their Mimickers. North American Journal of Medicine and Science. 2012;5(1):20-28. https://doi.org/10.7156/v5i1p020
  5. Tsujigiwa H, Nagatsuka H, Han PP, Gunduz M, Siar CH, Oida S, Nagai N. Analysis of amelogenin gene (AMGX, AMGY) expression in ameloblastoma. Oral Oncol. 2005;41(8):843-850. https://doi.org/10.1016/j.oraloncology.2005.04.005
  6. Miletich I, Sharpe PT. Normal and abnormal dental development. Hum Mol Genet. 2003;12:69-73. https://doi.org/10.1093/hmg/ddg085
  7. Liu F, Millar SE. Wnt⁄b-catenin signaling in oral tissue development and disease. J Dent Res. 2010;89(4):318-330. https://doi.org/10.1177/0022034510363373
  8. Kibe T, Fuchigami T, Kishida M, Iijima M, Ishihata K, Hijioka H, Miyawaki A, Semba I, Nakamura N, Kiyono T, Kishida S. A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to Wnt-3a and induces osteoclastogenesis. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2013;115(6):780-788. https://doi.org/10.1016/j.oooo.2013.03.005
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  10. Semkin VA, Babichenko II. Odontogenic cysts and tumors (diagnosis and treatment). M.: GEOTAR-Media; 2017. (In Russ.)

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