The role of Wnt/β-catenin signaling pathway in ameloblastoma formation

Babichenko I.I.; Tsimbalist N.S.; Rybalskaya V.F.; Sherstnev A.A.; Semkin V.A.

doi:https://doi.org/10.17116/stomat201897222-24

Babichenko I.I.

Russian University of People’s Friendship, Moscow, Russia, 117198

Tsimbalist N.S.

Department of Pathological Anatomy, People’s Friendship University of Russia, Moscow, Russia

Rybalskaya V.F.

Department of Pathological Anatomy, People’s Friendship University of Russia, Moscow, Russia

Sherstnev A.A.

Peoples’ Friendship University of Russia, Moscow, Russia, 117198

Semkin V.A.

Otdelenie khirurgicheskoĭ stomatologii FGBU "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii" Minzdrava RF, Moskva

The role of Wnt/β-catenin signaling pathway in ameloblastoma formation

Authors:

Babichenko I.I., Tsimbalist N.S., Rybalskaya V.F., Sherstnev A.A., Semkin V.A.

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Journal: Stomatology. 2018;97(2): 22‑24

DOI: 10.17116/stomat201897222-24

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To cite this article:

Babichenko II, Tsimbalist NS, Rybalskaya VF, Sherstnev AA, Semkin VA. The role of Wnt/β-catenin signaling pathway in ameloblastoma formation. Stomatology. 2018;97(2):22‑24. (In Russ.)
https://doi.org/10.17116/stomat201897222-24

Подписка 2026 Стоматология (Stomatology)

Использование инфографики авторами научных работ

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Abstract:

The aim of the study was to assess the role of the canonical Wnt/β-catenin signaling pathway in the formation and clinical course of various histological variants of ameloblastoma. Materials and methods: 76 cases of ameloblastoma were investigated, the average age of the patients was 46 years. There were 49 (64.5%) cases of recurrence of the disease. Tissue antigens were determined using monoclonal rabbit antibodies to Ki-67 and β-catenin. Results: it was found correlation between the proliferative activity of ameloblastoma cells and the intranuclear localization of β-catenin, indicating the activation of the Wnt/β-catenin-signaling pathway. It was shown that the nuclear localization of β-catenin is positively correlated with the recurrence. Conclusion: The Wnt/β-catenin signaling pathway is involved in a formation and progression of ameloblastoma.

Keywords:

immunohistochemistry

ameloblastoma

Ki-67

Wnt/β-catenin signaling pathway

Authors:

Babichenko I.I.

Russian University of People’s Friendship, Moscow, Russia, 117198

Tsimbalist N.S.

Department of Pathological Anatomy, People’s Friendship University of Russia, Moscow, Russia

Rybalskaya V.F.

Department of Pathological Anatomy, People’s Friendship University of Russia, Moscow, Russia

Sherstnev A.A.

Peoples’ Friendship University of Russia, Moscow, Russia, 117198

Semkin V.A.

Otdelenie khirurgicheskoĭ stomatologii FGBU "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii" Minzdrava RF, Moskva

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References:

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