Neuroendocrine tumor of the extrahepatic bile ducts. Case report and literature review

Suraev D.E.; Zagagov S.O.; Savelov N.A.; Ajazova A.A.; Kanner D.Yu.; Paklina O.V.

doi:https://doi.org/10.17116/patol20258701141

Suraev D.E.

Moscow City Oncology Hospital No. 62

ORCID: 0009-0007-9435-7527

Zagagov S.O.

Moscow City Oncology Hospital No. 62

ORCID: 0000-0003-3551-9868

Savelov N.A.

Moscow City Oncology Hospital No. 62

ORCID: 0000-0002-4164-2240

Ajazova A.A.

Moscow City Oncology Hospital No. 62

ORCID: 0009-0003-9185-8036

Kanner D.Yu.

Moscow City Oncology Hospital No. 62

ORCID: 0000-0002-0649-6452

Paklina O.V.

A.V. Vishnevsky National Medical Research Center of Surgery;
A.S. Loginov Clinical Research Center of Moscow

ORCID: 0000-0001-6373-1888

Neuroendocrine tumor of the extrahepatic bile ducts. Case report and literature review

Authors:

Suraev D.E., Zagagov S.O., Savelov N.A., Ajazova A.A., Kanner D.Yu., Paklina O.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2025;87(1): 41‑47

DOI: 10.17116/patol20258701141

Read: 1059 times

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To cite this article:

Suraev DE, Zagagov SO, Savelov NA, Ajazova AA, Kanner DYu, Paklina OV. Neuroendocrine tumor of the extrahepatic bile ducts. Case report and literature review. Russian Journal of Archive of Pathology. 2025;87(1):41‑47. (In Russ.)
https://doi.org/10.17116/patol20258701141

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)

Использование инфографики авторами научных работ

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Abstract:

Neuroendocrine neoplasms (NENs) are heterogeneous tumors with a common phenotype. There are two fundamentally different groups of NENs: well differentiated with a low proliferative index, called neuroendocrine tumors (NETs) and poorly differentiated with a high proliferative index, called neuroendocrine carcinoma (NEC). Extrahepatic bile duct NETs (EBNETs) account for 0.2% to 2% of all gastrointestinal NETs and up to 2% of all malignant neoplasms of the extrahepatic bile ducts. To date, 114 cases of EBNETs have been described, with disease-free survival ranging from 2 to 240 months. In most cases, the tumors expressed Chromogranin A, Synaptophysin, CD56, and NSE. This report presents a rare case of an EBNET in a 61-year-old patient following resection of the extrahepatic bile ducts. The description includes data from radiological and ultrasound diagnostic methods, macro- and microscopic characteristics of the tumor, and immunohistochemical profile.

Keywords:

neuroendocrine tumor of the extrahepatic bile ducts

neuroendocrine cancer of the extrahepatic bile ducts

Chromogranin A

Synaptophysin

CD56

Ki-67

Authors:

Suraev D.E.

Moscow City Oncology Hospital No. 62

ORCID: 0009-0007-9435-7527

Zagagov S.O.

Moscow City Oncology Hospital No. 62

ORCID: 0000-0003-3551-9868

Savelov N.A.

Moscow City Oncology Hospital No. 62

ORCID: 0000-0002-4164-2240

Ajazova A.A.

Moscow City Oncology Hospital No. 62

ORCID: 0009-0003-9185-8036

Kanner D.Yu.

Moscow City Oncology Hospital No. 62

ORCID: 0000-0002-0649-6452

Paklina O.V.

A.V. Vishnevsky National Medical Research Center of Surgery;
A.S. Loginov Clinical Research Center of Moscow

ORCID: 0000-0001-6373-1888

Received:

20.06.2024

Accepted:

30.10.2024

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