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Bykova N.I.

Kuban State Medical University, Krasnodar, Russia

Sirak S.V.

Severo-Osetinskaia gosudarstvennaia meditsinskaia akademiia, Vladikavkaz;
Stavropol'skaia gosudarstvennaia meditsinskaia akademiia

Kobylkina T.L.

Stavropol State Medical University, Stavropol, Russia

Odolsky A.V.

Stavropol State Medical University, Stavropol, Russia

Bykov I.M.

Kuban State Medical University, Krasnodar, Russia

Arutyunov A.V.

Kuban State Medical University, Krasnodar, Russia

Optimization of reparative dentinogenesis in experimental osteoporosis

Authors:

Bykova N.I., Sirak S.V., Kobylkina T.L., Odolsky A.V., Bykov I.M., Arutyunov A.V.

More about the authors

Journal: Stomatology. 2017;96(6): 4‑8

DOI: 10.17116/stomat20179664-8

Views: 711

Downloaded: 8

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Table of contents

OPTIMIZATION OF REPARATIVE DENTINOGENESIS IN EXPERIMENTAL OSTEOPOROSIS
OPTIMIZATION OF REPARATIVE DENTINOGENESIS IN EXPERIMENTAL OSTEOPOROSIS

To cite this article:

Bykova NI, Sirak SV, Kobylkina TL, Odolsky AV, Bykov IM, Arutyunov AV. Optimization of reparative dentinogenesis in experimental osteoporosis. Stomatology. 2017;96(6):4‑8. (In Russ.)
https://doi.org/10.17116/stomat20179664-8

Подписка 2025-2 (Stomatology)
 
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The aim of the study was to assess histochemical changes of the dental pulp in direct pulp capping/experimental osteoporosis animal model. The study was performed on 20 two-year sheep with simulated acute pulpitis divided in 2 groups: main (15 animals/120 teeth) and control (5 animals/40 teeth). Direct pulp capping in the main group included tissue-engineered structure composed of a hydrogel PuraMatrix/3DM with ectomesenchymal stem cells immobilized on collagen sponge. In the control group collagen sponges with hydrocortisone furatsilin, chondroitin sulfate, аnaesthesinum were used for the same purpose. Dentinal bridge formation was much slower in controls than in the main group. Developed tissue-engineered design optimizes each stage of the healing process by protecting the pulp from infection, reduction of exudation, hemostatic effect and in long term contributes to a significant acceleration of the formation of the dentinal bridge.

Keywords:

experiment
osteoporosis
pulp
tissue-engineered design

Authors:

Bykova N.I.

Kuban State Medical University, Krasnodar, Russia

Sirak S.V.

Severo-Osetinskaia gosudarstvennaia meditsinskaia akademiia, Vladikavkaz;
Stavropol'skaia gosudarstvennaia meditsinskaia akademiia

Kobylkina T.L.

Stavropol State Medical University, Stavropol, Russia

Odolsky A.V.

Stavropol State Medical University, Stavropol, Russia

Bykov I.M.

Kuban State Medical University, Krasnodar, Russia

Arutyunov A.V.

Kuban State Medical University, Krasnodar, Russia

List of references:

  1. Sirak SV, Sirak AG, Kopylova IA, Biragova AK. Study of morphological changes in the dental pulp following the treatment of deep caries and focal acute pulpitis in experiment. Meditsinskii vestnik Severnogo Kavkaza. 2011;23(3):29-33. (In Russ.)
  2. Sirak SV, Kobylkina TL, Sirak AG, Bykova NI, Arutyunov AV. Experimental study of the dynamics of education substitution of dentin. Vestnik Volgogradskogo gosudarstvennogo meditsinskogo universiteta. 2016;4(60):59-62. (In Russ.)
  3. Ivanova EV, Shamkhalov GS, Dmitrieva NA, Akhmedova ZR. Specific features of materials for initial pulpitis treatment. Stomatologiya. 2014;93(2):10-13. (In Russ.)
  4. Sirak AG, Parazyan LA, Shchetinin EV, Sirak SV, Vafiadi MYu, Arutyunov AV, Adamchik AA. Clinical and morphological background for application of the composite paste in biological treatment of pulpitis. Meditsinskii vestnik Severnogo Kavkaza. 2015;10: 4(40):384-388. (In Russ.) https://doi.org/10.14300/mnnc.2015.10094
  5. Baĭdik OD, Titarenko MA, Sysoliatin PG. Tissue engineering in dentistry. Stomatologiya. 2015; 94(2):65-68. (In Russ.) https://doi.org/10.17116/stomat201594265-68
  6. Volozhin AI, Vasilev AYu, Malginov NN, Bulanova IM, Grigorian AS, Kiseleva EV, Cherniaev SE, Tarasenko IV. Use of mesenchymal stem cells for reparative processes activation in bone jaw tissue in experimental conditions. Stomatologiya. 2010;89(1):10-14. (In Russ.)
  7. Shchetinin EV, Sirak SV, Khodzhayan AB, Dilekova OV, Sirak AG, Vafiadi MY, Parаzyan LA, Arutyunov AV. Pathogenetic aspects of dental pulp pathology. Medical News of North Caucasus. 2015;10(2):187-191. https://doi.org/10.14300/mnnc.2015.10044
  8. Lee Y-H, Kang Y-M, Heo M-J, Kim G-E, Bhattarai G, Lee N-H, Yu M-K, YThe H-K. Survival role of peroxisome proliferator-activated receptor gamma induces odontoblast differentiation against oxidative stress in human dental pulp cells. Journal of Endodontics. 2013;39(2):236-241. https://doi.org/10.1016/j.joen.2012.11.006
  9. Pisciotta A, Carnevale G, Meloni S, Riccio M, De Biasi S, Gibellini L, Ferrari A, Bruzzesi G, De Pol A. Human Dental pulp stem cells (hDPSCs): Isolation, enrichment and comparative differentiation of two sub-populations Integrative control of development. BMC Developmental Biology. 2015;15(1). https://doi.org/10.1186/s12861-015-0065-x
  10. Han C, Yang Z, Zhou W, Jin F, Song Y, Wang Y, Huo N, Chen L, Qian H, Hou R, Duan Y, Jin Y. Periapical follicle stem cell: A promising candidate for cementum/periodontal ligament regeneration and bio-root engineering. Stem Cells and Development. 2010;19(9):1405-1415. https://doi.org/10.1089/scd.2009.0277
  11. Wang W, Li W, Ong L-L, Furlani D, Kaminski A, Liebold A, Steinhoff G, Ma N, Lützow K, Lendlein A, Wang J, Li R. Localized sdf-1alpha gene release mediated by collagen substrate induces cd117+ stem cells homing. Journal of Cellular and Molecular Medicine. 2010;14(1-2):392-402. https://doi.org/10.1111/j.1582-4934.2008.00624.x
  12. Ferro F, Spelat R, Pandolfi M, Beltrami AP, Cesselli D, Beltrami CA, Curcio F, D’Aurizio F, Puppato E, Falini G. Dental pulp stem cells differentiation reveals new insights in oct4a dynamics. PLoS ONE. 2012;7(7):41774. https://doi.org/10.1371/journal.pone.0041774

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