Optimization of reparative dentinogenesis in experimental osteoporosis

Bykova N.I.; Sirak S.V.; Kobylkina T.L.; Odolsky A.V.; Bykov I.M.; Arutyunov A.V.

doi:https://doi.org/10.17116/stomat20179664-8

Bykova N.I.

Kuban State Medical University, Krasnodar, Russia

Sirak S.V.

Severo-Osetinskaia gosudarstvennaia meditsinskaia akademiia, Vladikavkaz;
Stavropol'skaia gosudarstvennaia meditsinskaia akademiia

Kobylkina T.L.

Stavropol State Medical University, Stavropol, Russia

Odolsky A.V.

Stavropol State Medical University, Stavropol, Russia

Bykov I.M.

Kuban State Medical University, Krasnodar, Russia

Arutyunov A.V.

Kuban State Medical University, Krasnodar, Russia

Optimization of reparative dentinogenesis in experimental osteoporosis

Authors:

Bykova N.I., Sirak S.V., Kobylkina T.L., Odolsky A.V., Bykov I.M., Arutyunov A.V.

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Journal: Stomatology. 2017;96(6): 4‑8

DOI: 10.17116/stomat20179664-8

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To cite this article:

Bykova NI, Sirak SV, Kobylkina TL, Odolsky AV, Bykov IM, Arutyunov AV. Optimization of reparative dentinogenesis in experimental osteoporosis. Stomatology. 2017;96(6):4‑8. (In Russ.)
https://doi.org/10.17116/stomat20179664-8

Подписка 2026 Стоматология (Stomatology)

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Abstract:

The aim of the study was to assess histochemical changes of the dental pulp in direct pulp capping/experimental osteoporosis animal model. The study was performed on 20 two-year sheep with simulated acute pulpitis divided in 2 groups: main (15 animals/120 teeth) and control (5 animals/40 teeth). Direct pulp capping in the main group included tissue-engineered structure composed of a hydrogel PuraMatrix/3DM with ectomesenchymal stem cells immobilized on collagen sponge. In the control group collagen sponges with hydrocortisone furatsilin, chondroitin sulfate, аnaesthesinum were used for the same purpose. Dentinal bridge formation was much slower in controls than in the main group. Developed tissue-engineered design optimizes each stage of the healing process by protecting the pulp from infection, reduction of exudation, hemostatic effect and in long term contributes to a significant acceleration of the formation of the dentinal bridge.

Keywords:

experiment

osteoporosis

pulp

tissue-engineered design

Authors:

Bykova N.I.

Kuban State Medical University, Krasnodar, Russia

Sirak S.V.

Severo-Osetinskaia gosudarstvennaia meditsinskaia akademiia, Vladikavkaz;
Stavropol'skaia gosudarstvennaia meditsinskaia akademiia

Kobylkina T.L.

Stavropol State Medical University, Stavropol, Russia

Odolsky A.V.

Stavropol State Medical University, Stavropol, Russia

Bykov I.M.

Kuban State Medical University, Krasnodar, Russia

Arutyunov A.V.

Kuban State Medical University, Krasnodar, Russia

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References:

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