Transcatheter implantation of self-opening pulmonary artery valve in a preclinical animal study

Rzaeva K.A.; Manukyan S.N.; Vladimirov S.V.; Borodin V.P.; Zhuravleva I.Yu.; Bogachev-Prokofiev A.V.; Soynov I.A.

doi:https://doi.org/10.17116/kardio202518041454

Rzaeva K.A.

Meshalkin National Medical Research Center

ORCID: 0000-0001-7254-0733

Manukyan S.N.

Meshalkin National Medical Research Center

ORCID: 0000-0002-7083-2297

Vladimirov S.V.

Meshalkin National Medical Research Center

ORCID: 0000-0002-5902-1442

Borodin V.P.

Meshalkin National Medical Research Center

ORCID: 0009-0009-1725-0499

Zhuravleva I.Yu.

Meshalkin National Medical Research Center

ORCID: 0000-0002-1935-4170

Bogachev-Prokofiev A.V.

Meshalkin National Medical Research Center

SPIN RSCI: 4448-6999
Scopus AuthorID: 55846629000
ResearcherID: L-7881-2014
ORCID: 0000-0003-4625-4631

Soynov I.A.

Meshalkin National Medical Research Center

ORCID: 0000-0003-3691-2848

Transcatheter implantation of self-opening pulmonary artery valve in a preclinical animal study

Authors:

Rzaeva K.A., Manukyan S.N., Vladimirov S.V., Borodin V.P., Zhuravleva I.Yu., Bogachev-Prokofiev A.V., Soynov I.A.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2025;18(4): 454‑459

DOI: 10.17116/kardio202518041454

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To cite this article:

Rzaeva KA, Manukyan SN, Vladimirov SV, Borodin VP, Zhuravleva IYu, Bogachev-Prokofiev AV, Soynov IA. Transcatheter implantation of self-opening pulmonary artery valve in a preclinical animal study. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;18(4):454‑459. (In Russ.)
https://doi.org/10.17116/kardio202518041454

Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)

Использование инфографики авторами научных работ

OBJECTIVE

To evaluate early postoperative and mid-term results of transcatheter implantation of pulmonary artery valve.

MATERIAL AND METHODS

Mini-pigs ICiG were used in this preclinical study. The object of the study was transcatheter pulmonary valve bioprosthesis. We used 2 healthy white pigs (2 females) aged 12 and 14 months, respectively. Weight of pigs was 56 and 60 kg, respectively. Pulmonary valve implantation was performed through left-sided anterior mini-thoracotomy.

RESULTS

Both implantations through mini-thoracotomy were successful. Mean pressure gradient was 14 and 10 mm Hg, respectively. After 3 months, transvalvular pressure gradient was 17.6 and 14.7 mm Hg, respectively. There was no central regurgitation. We observed mild periprosthetic regurgitation in the second animal without any clinical symptoms.

CONCLUSION

Design of new transcatheter self-opening pulmonary valve is safe and effective.

Keywords:

experiment

self-opening frame

mini-thoracotomy

Authors:

Rzaeva K.A.

Meshalkin National Medical Research Center

ORCID: 0000-0001-7254-0733

Manukyan S.N.

Meshalkin National Medical Research Center

ORCID: 0000-0002-7083-2297

Vladimirov S.V.

Meshalkin National Medical Research Center

ORCID: 0000-0002-5902-1442

Borodin V.P.

Meshalkin National Medical Research Center

ORCID: 0009-0009-1725-0499

Zhuravleva I.Yu.

Meshalkin National Medical Research Center

ORCID: 0000-0002-1935-4170

Bogachev-Prokofiev A.V.

Meshalkin National Medical Research Center

SPIN RSCI: 4448-6999
Scopus AuthorID: 55846629000
ResearcherID: L-7881-2014
ORCID: 0000-0003-4625-4631

Soynov I.A.

Meshalkin National Medical Research Center

ORCID: 0000-0003-3691-2848

Received:

03.03.2024

Accepted:

29.04.2024

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References:

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