The expression of TLR4 and HBD3 in epithelial cells of oral mucosa by surgical treatment of periodontitis

Zorina O.A.; Gankovskaya L.V.; Balykin R.A.; Svitich O.A.; Ivaniushko T.P.

doi:https://doi.org/10.17116/stomat201695413-15

Zorina O.A.

GBOU VPO "Pervyĭ MGMU imeni I.M. Sechenova"

Gankovskaya L.V.

Department of Obstetrics and Gynecology, Faculty of Pediatrics, Department of Immunology, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Balykin R.A.

Kafedra GKhS i ChLKh PMGMU im. I.M. Sechenova;
ZAO "NPF DNK-Tekhnologiia", Moskva

Svitich O.A.

Department of Obstetrics and Gynecology, Faculty of Pediatrics, Department of Immunology, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Ivaniushko T.P.

Kafedra GKhS i ChLKh PMGMU im. I.M. Sechenova;
ZAO "NPF DNK-Tekhnologiia", Moskva

The expression of TLR4 and HBD3 in epithelial cells of oral mucosa by surgical treatment of periodontitis

Authors:

Zorina O.A., Gankovskaya L.V., Balykin R.A., Svitich O.A., Ivaniushko T.P.

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Journal: Stomatology. 2016;95(4): 13‑15

DOI: 10.17116/stomat201695413-15

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To cite this article:

Zorina OA, Gankovskaya LV, Balykin RA, Svitich OA, Ivaniushko TP. The expression of TLR4 and HBD3 in epithelial cells of oral mucosa by surgical treatment of periodontitis. Stomatology. 2016;95(4):13‑15. (In Russ.)
https://doi.org/10.17116/stomat201695413-15

Подписка 2026 Стоматология (Stomatology)

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Abstract:

The expression of TLR4 and HBD3 in epithelial cells of the oral cavity was studied using polymerase chain reaction in real-time in patients with inflammatory and destructive periodontal lesions before and after surgery using osteoplastic material. Analysis of TLR4 and HBD3 expression in epithelial cells demonstrates the key role of the innate immune factors in the pathogenesis of inflammatory and destructive periodontal lesions. TLR4 gene expression was increased 1.5-7.0 times and HBD3 1.5-5.0 times compared to healthy individuals. Surgical treatment resulted in an effective rehabilitation and normalization of innate immunity.

Keywords:

inflammatory and destructive periodontal lesions

innate immunity

TLR4 gene expression and HBD-3

polymerase chain reaction in real time (PCR PB)

surgical treatment

Authors:

Zorina O.A.

GBOU VPO "Pervyĭ MGMU imeni I.M. Sechenova"

Gankovskaya L.V.

Department of Obstetrics and Gynecology, Faculty of Pediatrics, Department of Immunology, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Balykin R.A.

Kafedra GKhS i ChLKh PMGMU im. I.M. Sechenova;
ZAO "NPF DNK-Tekhnologiia", Moskva

Svitich O.A.

Department of Obstetrics and Gynecology, Faculty of Pediatrics, Department of Immunology, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Ivaniushko T.P.

Kafedra GKhS i ChLKh PMGMU im. I.M. Sechenova;
ZAO "NPF DNK-Tekhnologiia", Moskva

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References:

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