Expression of NOD-like receptors in periodontal tissues of patients with aggressive periodontitis

Fomenko E.V.; Grudyanov A.I.; Kalyuzhin O.V.; Maybogin A.M.; Babichenko I.I.

doi:https://doi.org/10.17116/stomat202510404117

Fomenko E.V.

Research Institute of Dentistry and Maxillofacial Surgery

ORCID: 0000-0003-4747-8039

Grudyanov A.I.

Research Institute of Dentistry and Maxillofacial Surgery

ORCID: 0000-0003-3818-9307

Kalyuzhin O.V.

Sechenov First Moscow State Medical University

ORCID: 0000-0003-3628-2436

Maybogin A.M.

Research Institute of Dentistry and Maxillofacial Surgery;
Patrice Lumumba Peoples’ Friendship University of Russia

ORCID: 0000-0003-1582-2106

Babichenko I.I.

Research Institute of Dentistry and Maxillofacial Surgery;
Patrice Lumumba Peoples’ Friendship University of Russia

ORCID: 0000-0001-5512-6813

Expression of NOD-like receptors in periodontal tissues of patients with aggressive periodontitis

Authors:

Fomenko E.V., Grudyanov A.I., Kalyuzhin O.V., Maybogin A.M., Babichenko I.I.

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Journal: Stomatology. 2025;104(4): 17‑21

DOI: 10.17116/stomat202510404117

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To cite this article:

Fomenko EV, Grudyanov AI, Kalyuzhin OV, Maybogin AM, Babichenko II. Expression of NOD-like receptors in periodontal tissues of patients with aggressive periodontitis. Stomatology. 2025;104(4):17‑21. (In Russ.)
https://doi.org/10.17116/stomat202510404117

Подписка 2026 Стоматология (Stomatology)

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OBJECTIVE

To study the expression of NOD-like receptors (NLRs) in periodontal tissue cells of patients with aggressive periodontitis before and after complex treatment.

MATERIAL AND METHODS

An immunohistochemical study of NLR expression (NOD1, NOD2, NLRC3, NLRP3, NLRP7, NLRP12, NAIP) was performed in periodontal tissue samples from patients with aggressive periodontitis before and after complex treatment, as well as in samples of the gingival mucosa of patients with gingival fibroids without signs of inflammation, who served as a control group.

RESULTS

In the control group, NLR expression in the multilayer squamous epithelium of the gingival mucosa was not detected. In patients with aggressive periodontitis, during the exacerbation period, pronounced expression of all studied NLRs was revealed in the inflammatory infiltrate cells of the subepithelial tissues of the periodontal pocket, as well as NOD1, NLRP3, NLRP12 and NAIP in the nuclei and cytoplasm of the cells of the multilayer squamous epithelium of the periodontal pocket. During complex treatment, the expression of most NLRs in epithelial cells persists for 21 days, while it decreases in the inflammatory infiltrate cells of the subepithelial tissues of the periodontal pocket.

CONCLUSION

Statistically significant differences between IHC expression parameters before and after treatment according to the criterion of “inflammatory infiltrate” were found among such receptors as NAIP, NLRP12 and NLRP7.

Keywords:

NOD-like receptors

aggressive form of periodontitis

mucosal epithelium

innate immunity

Authors:

Fomenko E.V.

Research Institute of Dentistry and Maxillofacial Surgery

ORCID: 0000-0003-4747-8039

Grudyanov A.I.

Research Institute of Dentistry and Maxillofacial Surgery

ORCID: 0000-0003-3818-9307

Kalyuzhin O.V.

Sechenov First Moscow State Medical University

ORCID: 0000-0003-3628-2436

Maybogin A.M.

Research Institute of Dentistry and Maxillofacial Surgery;
Patrice Lumumba Peoples’ Friendship University of Russia

ORCID: 0000-0003-1582-2106

Babichenko I.I.

Research Institute of Dentistry and Maxillofacial Surgery;
Patrice Lumumba Peoples’ Friendship University of Russia

ORCID: 0000-0001-5512-6813

Received:

15.04.2025

Accepted:

12.05.2025

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