Neuropeptide Y and inflammatory indices in women after repeated cesarean section

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OBJECTIVE

To study the correlation between immunohistochemical expression of NPY in myome-trial biopsies and inflammation indices in patients with repeated cesarean section.

MATERIAL AND METHODS

A comprehensive examination of 22 women who delivered by repeated cesarean section at 37—41 weeks of pregnancy was conducted in the obstetric hospital of the Kursk State Healthcare Institution �Emergency Medical Care Hospital�. In addition to the analy-sis of objective, obstetric, ultrasound and Doppler data, immunohistochemical staining of uterine biopsies with polyclonal antibodies recognizing NPY was performed. Based on the general blood test investigation, inflammation indices (neutrophil to lymphocyte ratio and Garkavi index) were determined and their correlation with the degree of NPY expression was established.

RESULTS

NPY expression in decidual cells correlated positively with the neutrophil-lymphocyte ratio and negatively with the Garkavi index in the entire study group.

CONCLUSION

Inflammatory and infectious processes in the uterus stimulate NPY expression, which subsequently affects the contractility of the myometrium. A high NPY level corresponds to the presence of severe inflammation and failure of the immune response, indicating an im-portant immunological role of this neuropeptide in the endometrium.

Keywords:

neuropeptide Y

neutrophil-to-lymphocyte ratio

Garkavi index

repeated cesarean section

inflammation

Authors:

Sebyakina T.A.

Kursk State Medical University

ORCID: 0009-0007-6706-549X

Ivanova O.Yu.

Kursk State Medical University

ORCID: 0000-0003-2350-1740

Ishunina T.A.

Kursk State Medical University

ORCID: 0000-0002-2743-7515

Received:

09.04.2024

Accepted:

07.05.2024

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