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Kazantseva V.D.

Moscow Regional Research Institute of Obstetrics and Gynecology

Ailarova I.M.

Moscow Regional Research Institute of Obstetrics and Gynecology

Me’lnikov A.P.

Moscow Regional Research Institute of Obstetrics and Gynecology

Markers of preeclampsia

Authors:

Kazantseva V.D., Ailarova I.M., Me’lnikov A.P.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2022;22(4): 31‑38

DOI: 10.17116/rosakush20222204131

Read: 2907 times

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Table of contents

MARKERS OF PREECLAMPSIA
MARKERS OF PREECLAMPSIA

To cite this article:

Kazantseva VD, Ailarova IM, Me’lnikov AP. Markers of preeclampsia. Russian Bulletin of Obstetrician-Gynecologist. 2022;22(4):31‑38. (In Russ.)
https://doi.org/10.17116/rosakush20222204131

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Preeclampsia, manifested as new-onset arterial hypertension and proteinuria in the third trimester, can rapidly progress to serious complications, including death of both the mother and the fetus. Although the cause of preeclampsia is still debated, it can be assumed that the placenta plays a central role in the pathogenesis of this syndrome. The role of abnormal placentation and the involvement of placental factors in the pathogenesis of preeclampsia are discussed. The pre-sented biomarkers can be used for the prognosis and confirmation of the severity of preeclampsia.

Keywords:

pregnancy
preeclampsia
diagnostics
biomarkers

Authors:

Kazantseva V.D.

Moscow Regional Research Institute of Obstetrics and Gynecology

Ailarova I.M.

Moscow Regional Research Institute of Obstetrics and Gynecology

Me’lnikov A.P.

Moscow Regional Research Institute of Obstetrics and Gynecology

Received:

22.09.2021

Accepted:

18.10.2021

Close metadata

References:

  1. Poon LC, Shennan A, Hyett JA, Kapur A, Hadar E, Divakar H, McAuliffe F, da Silva Costa F, von Dadelszen P, McIntyre HD, Kihara AB, Di Renzo GC, Romero R, D’Alton M, Berghella V, Nicolaides KH, Hod M. The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and. Int J Gynaecol Obstet. 2019;146:3:390-391.  https://doi.org/10.1002/ijgo.12802
  2. Fishel Bartal M, Sibai BM. Eclampsia in the 21st century. Am J Obstet Gynecol. 2020;S0002-9378:20:31128-31125. https://doi.org/10.1016/j.ajog.2020.09.037
  3. WHO recommendations on drug treatment for non-severe hypertension in pregnancy. Geneva: World Health Organization; 2020.
  4. Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001;69:3:89-95.  https://doi.org/10.1067/mcp.2001.113989
  5. Turco MY, Moffett A. Development of the human placenta. Development. 2019;146:22:dev163428. Published 2019; Nov 27.  https://doi.org/10.1242/dev.163428
  6. Mayhew TM. Turnover of human villous trophoblast in normal pregnancy: what do we know and what do we need to know? Placenta. 2014;35:4:229-240.  https://doi.org/10.1016/j.placenta.2014.01.011
  7. Lala PK, Nandi P. Mechanisms of trophoblast migration, endometrial angiogenesis in preeclampsia: The role of decorin. Cell Adh Migr. 2016;10:1-2:111-125.  https://doi.org/10.1080/19336918.2015.1106669
  8. Hannan NJ, Jones RL, White CA, Salamonsen LA. The chemokines, CX3CL1, CCL14, and CCL4, promote human trophoblast migration at the feto-maternal interface. Biol Reprod. 2006;74:5:896-904.  https://doi.org/10.1095/biolreprod.105.045518
  9. Chau K, Hennessy A, Makris A. Placental growth factor and pre-eclampsia. J Hum Hypertens. 2017;31:12:782-786.  https://doi.org/10.1038/jhh.2017.61
  10. Saffer C, Olson G, Boggess KA, Beyerlein R, Eubank C, Sibai BM; NORMALS Study Group. Determination of placental growth factor (PlGF) levels in healthy pregnant women without signs or symptoms of preeclampsia. Pregnancy Hypertens. 2013;3:2:124-132.  https://doi.org/10.1016/j.preghy.2013.01.004
  11. Zeisler H, Llurba E, Chantraine F, Vatish M, Staff AC, Sennström M, Olovsson M, Brennecke SP, Stepan H, Allegranza D, Dilba P, Schoedl M, Hund M, Verlohren S. Predictive value of the sFlt-1:PlGF ratio in women with suspected preeclampsia. N Engl J Med. 2016;374:1:13-22.  https://doi.org/10.1056/NEJMoa1414838
  12. Caniggia I, Grisaru-Gravnosky S, Kuliszewsky M, Post M, Lye SJ. Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies. J Clin Invest. 1999;103:12:1641-1650. https://doi.org/10.1172/JCI6380
  13. Maharaj AS, Walshe TE, Saint-Geniez M, Venkatesha S, Maldonado AE, Himes NC, Matharu KS, Karumanchi SA, D’Amore PA. VEGF and TGF-beta are required for the maintenance of the choroid plexus and ependyma. J Exp Med. 2008;205:2:491-501.  https://doi.org/10.1084/jem.20072041
  14. Elmasri H, Karaaslan C, Teper Y, Ghelfi E, Weng M, Ince TA, Kozakewich H, Bischoff J, Cataltepe S. Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells. FASEB J. 2009;23:11:3865-3873. https://doi.org/10.1096/fj.09-134882
  15. Bolin M, Wiberg-Itzel E, Wikström AK, Goop M, Larsson A, Olovsson M, Akerud H. Angiopoietin-1/angiopoietin-2 ratio for prediction of preeclampsia. Am J Hypertens. 2009;22:8:891-895.  https://doi.org/10.1038/ajh.2009.97
  16. Roberts JM. Pathophysiology of ischemic placental disease. Semin Perinatol. 2014;38:3:139-145.  https://doi.org/10.1053/j.semperi.2014.03.005
  17. Radzinskii VE, Orazmuradov AA. Early pregnancy. 2nd ed. M.: StatusPraesens; 2009. (In Russ.).
  18. Sukhikh GT, Murashko LE. Preeclampsia. M.: GEOTAR-Media; 2010. (In Russ.).
  19. Gaccioli F, Aye ILMH, Sovio U, Charnock-Jones DS, Smith GCS. Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers. Am J Obstet Gynecol. 2018;218:2S:725-737.  https://doi.org/10.1016/j.ajog.2017.12.002
  20. Liu N, Guo YN, Gong LK, Wang BS. Advances in biomarker development and potential application for preeclampsia based on pathogenesis. Eur J Obstet Gynecol Reprod Biol X. 2020;9:100119. https://doi.org/10.1016/j.eurox.2020.100119
  21. Christians JK, Beristain AG. ADAM12 and PAPP-A: Candidate regulators of trophoblast invasion and first trimester markers of healthy trophoblasts. Cell Adh Migr. 2016;10:1-2:147-153.  https://doi.org/10.1080/19336918.2015.1083668
  22. Cunningham MW Jr, Williams JM, Amaral L, Usry N, Wallukat G, Dechend R, LaMarca B. Agonistic autoantibodies to the angiotensin II type 1 receptor enhance angiotensin II-induced renal vascular sensitivity and reduce renal function during pregnancy. Hypertension. 2016;68:5:1308-1313. https://doi.org/10.1161/HYPERTENSIONAHA.116.07971
  23. Herse F, Verlohren S, Wenzel K, Pape J, Muller DN, Modrow S, Wallukat G, Luft FC, Redman CW, Dechend R. Prevalence of agonistic autoantibodies against the angiotensin II type 1 receptor and soluble fms-like tyrosine kinase 1 in a gestational age-matched case study. Hypertension. 2009;53:2:393-398.  https://doi.org/10.1161/HYPERTENSIONAHA.108.124115
  24. Buttrup Larsen S, Wallukat G, Schimke I, Sandager A, Tvilum Christensen T, Uldbjerg N, Tørring N. Functional autoantibodies against endothelin-1 receptor type A and Angiotensin II receptor type 1 in patients with preeclampsia. Pregnancy Hypertens. 2018;14:189-194.  https://doi.org/10.1016/j.preghy.2018.10.002
  25. Li J, Wu G, Cao Y, Hou Z. Roles of miR-210 in the pathogenesis of pre-eclampsia. Arch Med Sci. 2019;15:1:183-190.  https://doi.org/10.5114/aoms.2018.73129
  26. Lv Y, Lu C, Ji X, Miao Z, Long W, Ding H, Lv M. Roles of microRNAs in preeclampsia. J Cell Physiol. 2019;234:2:1052-1061. https://doi.org/10.1002/jcp.27291
  27. Anton L, Olarerin-George AO, Schwartz N, Srinivas S, Bastek J, Hogenesch JB, Elovitz MA. MiR-210 inhibits trophoblast invasion and is a serum biomarker for preeclampsia. Am J Pathol. 2013;183:5:1437-1445. https://doi.org/10.1016/j.ajpath.2013.07.021
  28. Zhang Y, Zhao HJ, Xia XR, Diao FY, Ma X, Wang J, Gao L, Liu J, Gao C, Cui YG, Liu JY. Hypoxia-induced and HIF1α-VEGF-mediated tight junction dysfunction in choriocarcinoma cells: Implications for preeclampsia. Clin Chim Acta. 2019;489:203-211.  https://doi.org/10.1016/j.cca.2017.12.010
  29. Sriyanti R, Mose JC, Masrul M, Suharti N. The difference in Maternal serum hypoxia-inducible factors-1α levels between early onset and late-onset preeclampsia. Open Access Maced J Med Sci. 2019;7:13:2133-2137. https://doi.org/10.3889/oamjms.2019.601
  30. Szpera-Gozdziewicz A, Breborowicz GH. Endothelial dysfunction in the pathogenesis of pre-eclampsia. Front Biosci (Landmark Ed). 2014;19:734-746.  https://doi.org/10.2741/4240
  31. Adank MC, Benschop L, Peterbroers KR, Smak Gregoor AM, Kors AW, Mulder MT, Schalekamp-Timmermans S, Roeters Van Lennep JE, Steegers EAP. Is maternal lipid profile in early pregnancy associated with pregnancy complications and blood pressure in pregnancy and long term postpartum? Am J Obstet Gynecol. 2019;221:2:150.e1-150.e13.  https://doi.org/10.1016/j.ajog.2019.03.025
  32. Sun LJ, Xu GF, Lv M, Zhou H, Huang HF, Luo Q. Predictive value of maternal serum biomarkers for preeclampsia and bBirth weight: a case-control study in chinese pregnant women. J Womens Health (Larchmt). 2018;27:12:1519-1524. https://doi.org/10.1089/jwh.2017.6793
  33. Clausen T, Djurovic S, Henriksen T. Dyslipidemia in early second trimester is mainly a feature of women with early onset pre-eclampsia. BJOG. 2001;108:10:1081-1087. https://doi.org/10.1111/j.1471-0528.2001.00247.x
  34. Chau K, Hennessy A, Makris A. Placental growth factor and pre-eclampsia. J Hum Hypertens. 2017;31:12:782-786.  https://doi.org/10.1038/jhh.2017.61
  35. Agarwal R, Kumari N, Kar R, Chandra N, Nimesh A, Singh A, Radhakrishnan G. Evaluation of placental VEGFA mRNA expression in preeclampsia: a case control study. J Obstet Gynaecol India. 2019;69:2:142-148.  https://doi.org/10.1007/s13224-018-1128-2
  36. Nakada Y, Onoue K, Nakano T, Ishihara S, Kumazawa T, Nakagawa H, Ueda T, Nishida T, Soeda T, Okayama S, Watanabe M, Kawakami R, Saito Y. AST-120, an oral carbon absorbent, protects against the progression of atherosclerosis in a mouse chronic renal failure model by preserving sFlt-1 expression levels. Sci Rep. 2019;9:1:15571. Published 2019 Oct 30.  https://doi.org/10.1038/s41598-019-51292-9
  37. Chang X, Yao J, He Q, Liu M, Duan T, Wang K. Exosomes from women with preeclampsia induced vascular dysfunction by delivering sFlt (Soluble Fms-Like tyrosine kinase)-1 and sEng (soluble endoglin) to endothelial cells. Hypertension. 2018;72:6:1381-1390. https://doi.org/10.1161/HYPERTENSIONAHA.118.11706
  38. Zhang L, Li X, Zhou C, You Z, Zhang J, Cao G. The diagnosis values of serum STAT4 and sEng in preeclampsia. J Clin Lab Anal. 2020;34:2:e23073. https://doi.org/10.1002/jcla.23073
  39. Lee H. Cystatin C in pregnant women is not a simple kidney filtration marker. Kidney Res Clin Pract. 2018;37:4:313-314.  https://doi.org/10.23876/j.krcp.18.0146
  40. van der Laan SW, Fall T, Soumaré A, Teumer A, Sedaghat S, Baumert J, Zabaneh D, van Setten J, Isgum I, Galesloot TE, Arpegård J, Amouyel P, Trompet S, Waldenberger M, Dörr M, Magnusson PK, Giedraitis V, Larsson A, Morris AP, Felix JF, Morrison AC, Franceschini N, Bis JC, Kavousi M, O’Donnell C, Drenos F, Tragante V, Munroe PB, Malik R, Dichgans M, Worrall BB, Erdmann J, Nelson CP, Samani NJ, Schunkert H, Marchini J, Patel RS, Hingorani AD, Lind L, Pedersen NL, de Graaf J, Kiemeney LA, Baumeister SE, Franco OH, Hofman A, Uitterlinden AG, Koenig W, Meisinger C, Peters A, Thorand B, Jukema JW, Eriksen BO, Toft I, Wilsgaard T, Onland-Moret NC, van der Schouw YT, Debette S, Kumari M, Svensson P, van der Harst P, Kivimaki M, Keating BJ, Sattar N, Dehghan A, Reiner AP, Ingelsson E, den Ruijter HM, de Bakker PI, Pasterkamp G, Ärnlöv J, Holmes MV, Asselbergs FW. Cystatin C and cardiovascular disease: A Mendelian randomization study. J Am Coll Cardiol. 2016;68:9:934-945.  https://doi.org/10.1016/j.jacc.2016.05.092
  41. Zhang HB, Fan JM, Zhu LL, Yuan XH, Shen XW. Combination of NGAL and cystatin C for prediction of preeclampsia at 10-14 weeks of gestation. Clin Lab. 2019;65:5:10.7754/Clin.Lab.2018.180831. https://doi.org/10.7754/Clin.Lab.2018.180831
  42. Raijmakers MT, Dechend R, Poston L. Oxidative stress and preeclampsia: rationale for antioxidant clinical trials. Hypertension. 2004;44:4:374-380.  https://doi.org/10.1161/01.HYP.0000141085.98320.01
  43. Yang S, Lian G. ROS and diseases: role in metabolism and energy supply [published correction appears in Mol Cell Biochem. 2020 Feb 17. Mol Cell Biochem. 2020;467:1-2:1-12.  https://doi.org/10.1007/s11010-019-03667-9
  44. Gilani SI, Anderson UD, Jayachandran M, Weissgerber TL, Zand L, White WM, Milic N, Suarez MLG, Vallapureddy RR, Nääv Å, Erlandsson L, Lieske JC, Grande JP, Nath KA, Hansson SR, Garovic VD. Urinary extracellular vesicles of podocyte origin and renal injury in preeclampsia. J Am Soc Nephrol. 2017;28:11:3363-3372. https://doi.org/10.1681/ASN.2016111202
  45. Anderson UD, Gram M, Ranstam J, Thilaganathan B, Kerström B, Hansson SR. Fetal hemoglobin, α1-microglobulin and hemopexin are potential predictive first trimester biomarkers for preeclampsia. Pregnancy Hypertens. 2016;6:2:103-109.  https://doi.org/10.1016/j.preghy.2016.02.003
  46. Liu S, Sun Z, Chu P, Li H, Ahsan A, Zhou Z, Zhang Z, Sun B, Wu J, Xi Y, Han G, Lin Y, Peng J, Tang Z. EGCG protects against homocysteine-induced human umbilical vein endothelial cells apoptosis by modulating mitochondrial-dependent apoptotic signaling and PI3K/Akt/eNOS signaling pathways. Apoptosis. 2017;22:5:672-680.  https://doi.org/10.1007/s10495-017-1360-8
  47. Geldenhuys J, Rossouw TM, Lombaard HA, Ehlers MM, Kock MM. Disruption in the regulation of immune responses in the placental subtype of preeclampsia. Front Immunol. 2018;9:1659. https://doi.org/10.3389/fimmu.2018.01659
  48. Panwar M, Kumari A, Hp A, Arora R, Singh V, Bansiwal R. Raised neutrophil lymphocyte ratio and serum beta hCG level in early second trimester of pregnancy as predictors for development and severity of preeclampsia. Drug Discov Ther. 2019;13:1:34-37.  https://doi.org/10.5582/ddt.2019.01006
  49. Kang Q, Li W, Yu N, Fan L, Zhang Y, Sha M, Xiao J, Wu J, Kang Q, Chen S. Predictive role of neutrophil-to-lymphocyte ratio in preeclampsia: A meta-analysis including 3982 patients. Pregnancy Hypertens. 2020;20:111-118.  https://doi.org/10.1016/j.preghy.2020.03.009
  50. Bellos I, Karageorgiou V, Kapnias D, Karamanli KE, Siristatidis C. The role of interleukins in preeclampsia: A comprehensive review. Am J Reprod Immunol. 2018;80:6:e13055. https://doi.org/10.1111/aji.13055
  51. Salazar Garcia MD, Mobley Y, Henson J, Davies M, Skariah A, Dambaeva S, Gilman-Sachs A, Beaman K, Lampley C, Kwak-Kim J. Early pregnancy immune biomarkers in peripheral blood may predict preeclampsia. J Reprod Immunol. 2018;125:25-31.  https://doi.org/10.1016/j.jri.2017.10.048
  52. Lowry P, Woods R. The placenta controls the physiology of pregnancy by increasing the half-life in blood and receptor activity of its secreted peptide hormones. J Mol Endocrinol. 2018;60:1:23-30.  https://doi.org/10.1530/JME-17-0275
  53. Jannesari R, Kazemi E. Level of high sensitive C-reactive protein and procalcitonin in pregnant women with mild and severe preeclampsia. Adv Biomed Res. 2017;6:140.  https://doi.org/10.4103/2277-9175.218032
  54. Sotiriadis A, Hernandez-Andrade E, da Silva Costa F, Ghi T, Glanc P, Khalil A, Martins WP, Odibo AO, Papageorghiou AT, Salomon LJ, Thilaganathan B; ISUOG CSC Pre-eclampsia Task Force. ISUOG Practice Guidelines: role of ultrasound in screening for and follow-up of pre-eclampsia. Ultrasound Obstet Gynecol. 2019;53:1:7-22.  https://doi.org/10.1002/uog.20105
  55. Carbillon L, Challier JC, Alouini S, Uzan M, Uzan S. Uteroplacental circulation development: Doppler assessment and clinical importance. Placenta. 2001;22:10:795-799.  https://doi.org/10.1053/plac.2001.0732
  56. Cnossen JS, Morris RK, ter Riet G, Mol BW, van der Post JA, Coomarasamy A, Zwinderman AH, Robson SC, Bindels PJ, Kleijnen J, Khan KS. Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis. CMAJ. 2008;178:6:701-711.  https://doi.org/10.1503/cmaj.070430
  57. Odibo AO, Zhong Y, Goetzinger KR, Odibo L, Bick JL, Bower CR, Nelson DM. First-trimester placental protein 13, PAPP-A, uterine artery Doppler and maternal characteristics in the prediction of pre-eclampsia. Placenta. 2011;32:8:598-602.  https://doi.org/10.1016/j.placenta.2011.05.006
  58. de Oliveira CA, de Sá RA, Velarde LG, Marchiori E, Netto HC, Ville Y. Doppler velocimetry of the ophthalmic artery in normal pregnancy: reference values. J Ultrasound Med. 2009;28:5:563-569.  https://doi.org/10.7863/jum.2009.28.5.563
  59. Velauthar L, Plana MN, Kalidindi M, Zamora J, Thilaganathan B, Illanes SE, Khan KS, Aquilina J, Thangaratinam S. First-trimester uterine artery Doppler and adverse pregnancy outcome: a meta-analysis involving 55,974 women. Ultrasound Obstet Gynecol. 2014;43:5:500-507.  https://doi.org/10.1002/uog.13275
  60. Krasnopol’skii VI, Titchenko LI, Tumanova VA, Petrukhin VA, Chechneva MA, Pyrsikova ZhYu. Possibilities of using three-dimensional dopplerometry to study intraplacental blood flow in pregnant women with a high risk of developing perinatal pathology. Rossiiskii vestnik akushera-ginekologa. 2003;3:3:24-29. (In Russ.).
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