Possible influence of ectopic and placental inflammation on the activation of the immune system of a pregnant woman and programmed development of the fetus

Shcherbakov V.I.; Ryabichenko T.I.; Skosyreva G.A.; Obukhova O.O.; Trunov A.N.

doi:https://doi.org/10.17116/rosakush20212102114

Shcherbakov V.I.

Federal Research Center for Fundamental and Experimental Medicine

ORCID: 0000-0002-0261-970X

Ryabichenko T.I.

Federal Research Center for Fundamental and Translational Medicine

Skosyreva G.A.

Federal Research Center for Fundamental and Translational Medicine

Obukhova O.O.

Federal Research Center for Fundamental and Translational Medicine

Trunov A.N.

Federal Research Center for Fundamental and Translational Medicine

Possible influence of ectopic and placental inflammation on the activation of the immune system of a pregnant woman and programmed development of the fetus

Authors:

Shcherbakov V.I., Ryabichenko T.I., Skosyreva G.A., Obukhova O.O., Trunov A.N.

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Journal: Russian Bulletin of Obstetrician-Gynecologist. 2021;21(2): 14‑20

DOI: 10.17116/rosakush20212102114

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To cite this article:

Shcherbakov VI, Ryabichenko TI, Skosyreva GA, Obukhova OO, Trunov AN. Possible influence of ectopic and placental inflammation on the activation of the immune system of a pregnant woman and programmed development of the fetus. Russian Bulletin of Obstetrician-Gynecologist. 2021;21(2):14‑20. (In Russ.)
https://doi.org/10.17116/rosakush20212102114

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)

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OBJECTIVE

Determination of the levels of pro- and anti-inflammatory cytokines that induce changes in programmed fetal development in pregnant women with ectopic inflammation — chronic pyelonephritis in the stage of clinical remission and placental inflammation in chronic placental insufficiency, accompanied by intrauterine fetus’ growth retardation for corrective measures both at the stage of pre-gravid preparation and during pregnancy.

MATERIAL AND METHODS

It was examined 111 pregnant women in the third trimester with chronic pyelonephritis in the stage of clinical remission (27 pregnant women) and with chronic placental insufficiency accompanied by intrauterine fetus’ growth retardation (33 pregnant women). The control group included 51 practically healthy women with physiological pregnancy. The concentration of pro-inflammatory cytokines IL-6, IL-8, IL-17A, IFN-γ and anti-inflammatory cytokine IL-4 in the blood serum of patients was determined using enzyme immunoassay.

RESULTS

It was shown that in the studied pathological conditions during pregnancy, changes in the concentration of both anti-inflammatory and pro-inflammatory cytokines are observed. An increase in the levels of pro-inflammatory cytokines IL-6, IL-8, IL-17A, IFN-γ reflects the severity of the inflammatory response in the pathological state of the placenta. In pregnancy accompanied by chronic pyelonephritis in the stage of clinical remission, activation of the immune response characteristic of inflammation is also noted. In this case, inflammatory reactions with intrauterine fetus’ growth retardation are more pronounced than pregnancy accompanied by chronic pyelonephritis in the stage of remission. It can be assumed that any violation of the cytokine profile of both ectopic and intrauterine origin leads to a change in the programmed development of the fetus and further pathological conditions in the child.

CONCLUSION

The established presence of both ectopic and placental chronic inflammation requires increased attention not only during pregnancy, but also at the stage of pre-gravid preparation and diagnostic and corrective measures.

Keywords:

pregnancy

cytokines

ectopic and placental inflammation

Authors:

Shcherbakov V.I.

Federal Research Center for Fundamental and Experimental Medicine

ORCID: 0000-0002-0261-970X

Ryabichenko T.I.

Federal Research Center for Fundamental and Translational Medicine

Skosyreva G.A.

Federal Research Center for Fundamental and Translational Medicine

Obukhova O.O.

Federal Research Center for Fundamental and Translational Medicine

Trunov A.N.

Federal Research Center for Fundamental and Translational Medicine

Received:

02.07.2020

Accepted:

02.09.2020

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