The aim of the study is to evaluate the efficacy of magnetic resonance imaging-guided focused ultrasound ablation (MRgFUS ablation) in reproductive-age patients with symptomatic uterine fibroids. Material and methods. 54 women with symptomatic uterine myoma were examined and treated with MRgFUS ablation using the ExAblate-2000 («InSightec», Israel), combined into a single system with the 1.5 Tesla MRI Scanner («General Electric», USA). To evaluate the changes in clinical symptoms and imaging indices, 3 months after the treatment the patients were divided into 2 groups. The main group consisted of 32 patients who experienced complete relief of any clinical symptoms of uterine fibroids. The comparison group consisted of 22 patients who had no clinical efficacy or incomplete regression of their complaints after MRgFUS ablation. Of these 22 patients, 7 patients later underwent laparoscopic myomectomy with a histological and immunohistochemical study of the removed fibroid nodule. Results. Significant indices from ultrasound, Doppler and magnetic resonance imaging were determined for more possibly predicting the efficacy of treatment of uterine fibroids using MRgFUS ablation. These include single-nodule fibroids with localization on the anterior wall of the uterus and with a hypointense type of MR signal on T2-weighted image according to MRI, and a homogeneous structure of the myoma with a highly resistant type of blood flow through the nodule and in the spiral arteries of the uterus. Conclusion. The data obtained indicate that with certain indications and under the right conditions for their implementation, non-invasive organ-preserving methods for treating myoma in reproductive-age patients can be an alternative to surgical treatment. In cases of planned pregnancies, the non-invasive nature of the intervention will improve the chances of carrying a pregnancy to term in the operated uterus.