Laparoscopic transabdominal pre-peritoneal hernioplasty for inguinal hernia using a synthetic mesh prosthesis is the most common operation in modern surgical practice. Considering the minimally invasive access, infectious complications are rarely observed. The article presents a clinical case of a 36-year-old man who complained of pain in the right half of the abdomen, in the right inguinal region, increased body temperature to subfebrile digits, pain during urination and defecation for 4 months after laparoscopic transabdominal pre-peritoneal hernioplasty for inguinal hernia using synthetic mesh prosthesis. As a consequence of instrumental examination, an infected mesh prosthesis was diagnosed with the spread of purulent process to the organs of the abdominal cavity and the small pelvis. Thus, there are difficulties in choosing an adequate tactic of treatment of this category of patients, which consist in deciding whether it is necessary to continue conservative methods or to eliminate the suppurative mesh prosthesis by laparoscopic access, in case of difficulties during the operation to convert to laparotomy, thus saving the involved organs of the abdominal cavity and small pelvis. The aim of the article is to draw surgeons’ attention to the possibility of a rare late infectious complication after laparoscopic pre-peritoneal hernioplasty of right inguinal hernia: infection of the mesh prosthesis, with the subsequent spread of the purulent process to the abdominal cavity and pelvic organs. Emphasis is placed on the difficulties of preoperative diagnosis of the complication and its surgical correction by laparoscopic access. For the diagnosis of abscesses associated with the implantation of a synthetic mesh prosthesis, ultrasound and computer tomography with contrast are sufficiently informative methods of investigation.