Taking into account the high prevalence of recurrent miscarriage of pregnancy (from 2 to 5%), the insufficient study of its pathogenesis, and the significant negative impact of this pathology on the mental state of women, further study of this problem is very important. Objective — to determine the level of biomarkers of brain and nerve tissue damage, and pro-and anti-inflammatory interleukins in patients with recurrent and sporadic miscarriage to increase the effectiveness of their pregravid preparation. Material and methods. 150 patients of reproductive age were examined and divided into 5 groups of 30 women each: the 1st group consisted of nominally healthy non-pregnant patients; the 2nd group — healthy pregnant women in the first trimester of pregnancy with an uncomplicated obstetric and gynecological history; the 3rd group — patients with a history of sporadic miscarriage; 4th group — non-pregnant women in the pregravid preparation stage with a history of recurrent miscarriage; 5th — pregnant women in the first trimester of pregnancy with a history of recurrent miscarriage. The levels of markers of brain and nerve tissue damage were studied in the blood serum of all patients: brain-derived neurotrophic factor, ciliary neurotrophic factor, astrocytic glial specific S-100 protein, and interleukins IL-1β, IL-2, IL-4, IL-6, IL -8. In patients who experienced either sporadic or recurrent miscarriages, levels of apoptosis markers, including apoptosis-causing tumor necrosis factor ligand, and caspase-1 enzyme, were also measured by means of enzyme immunoassay. Results. It was found that recurrent and sporadic miscarriage changes the levels of markers of brain and nervous tissue damage (neurotrophic factor of the brain, astrocytic glia specific protein S-100), together with changes in the levels of interleukins IL-4, IL-1β and IL-6 and biomarkers of apoptosis. Conclusion. Considering the results, it is recommended that at the stage of pregravid preparation, patients at risk of miscarriage should undergo psychopharmacotherapy and psychotherapy aimed at eliminating the stress-induced complications (anxiety, depression) that accompany this pathology, combined with a treatment of immune disorders.