Diagnostic criteria for intrauterine infection during pregnancy

Close metadata

Recommended articles:

Modern ideas about the pathogenesis of chronic placental insufficiency. Russian Bulletin of Obstetrician-Gynecologist. 2024;(1):12-18

Changes in management tactics and treatment outcomes of patients with isthmic-cervical insufficiency in the second decade of the 21st century based on the results of research at the Surgut District Clinical Centre for Maternal and Child Health Care. Russian Bulletin of Obstetrician-Gynecologist. 2024;(1):47-53

Justification of systemic antibacterial therapy in patients with subclinical intrauterine infection during pregnancy. Russian Bulletin of Obstetrician-Gynecologist. 2024;(2):62-67

Clinical and anamnestic risk factors for the development of spontaneous premature birth in Siberian women of Slavic and Tuvan ethnic groups. Russian Bulletin of Obstetrician-Gynecologist. 2024;(4):42-47

Psychological aspects in predicting preterm labor. Russian Bulletin of Obstetrician-Gynecologist. 2024;(5):95-100

The course of pregnancy and its outcomes in women who have suffered COVID-19. Russian Journal of Human Reproduction. 2024;(1):92-99

MDSC expression analysis as an important marker of early delivery (a rewiew). Russian Journal of Human Reproduction. 2024;(2):74-79

The role of FABP4 in the development of fetal growth retardation in women with gestational diabetes mellitus and threatened late miscarriage diagnosed in the second trimester of pregnancy. Russian Journal of Human Reproduction. 2024;(3):50-56

High mobility group protein B1 (HMGB1) and the potential for inflammation amplification in preeclampsia and threatened preterm labor. Russian Journal of Human Reproduction. 2024;(5):82-88

Comparison of models for prediction of spontaneous preterm birth. Medical Technologies. Assessment and Choice. 2024;(4):10-19

Objective — to identify the prognostic criteria for obstetric and perinatal complications on the basis of an analysis of anamnestic data and the specific features of the course of current pregnancy in patients with morphologically verified intrauterine infection (IUI). Subject and methods. A total of 327 pregnant women enrolled in the study by continuous sampling were examined. Group 1 consisted of 130 patients, in whom IUI was verified by histological placental examination (a study group). Group 2 included 197 pregnant women whose placentas displayed no inflammatory changes (a comparison group). Clinical, laboratory, instrumental, microbiological, and pathological examinations were performed. Results. The women with morphologically confirmed IUI showed the features of their current pregnancy: the latter and early neonatality were more commonly complicated. The criteria for IUI during pregnancy can be considered to be a combination of the following factors: a compromised obstetric/gynecological history, cervicitis, recurrent threatened miscarriage, a number of echographic signs (abnormal amount of amniotic fluid, placental structural changes), uteroplacental circulatory disorders, and prothrombotic hemostasis. Miscarriage and preterm birth were significantly more frequently recorded in the study group. Conclusion. Identification of clinicoanamnestic, microbiological, pathological, and instrumental diagnostic criteria of IUI during pregnancy will be able to predict obstetric and perinatal complications of pregnancy and to timely use therapeutic and preventive measures to reduce perinatal losses. The authors declare no conflicts of interest.

Keywords:

cervititis

intrauterine infection

recurrent threatened miscarriage

preterm birth

placental insufficiency

early neonatal complications

Authors:

Kurnosenko I.V.

Department of Obstetrics and Gynecology, South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia

Dolgushina V.F.

Kafedra akusherstva i ginekologii

List of references:

Belotserkovtseva LD, Kasparova AE, Kovalenko LV, Sus LA, Mordovina II. Pathogenic mechanisms of cardio-placental insufficiency in intrauterine infection. Voprosy ginekologii, akusherstva i perinatologii. 2010;9:4:13-22. (In Russ.).
Belokrinitskaya TE. Patogeneticheskie aspekty khronicheskoi fetoplatsentarnoi nedostatochnosti v fokuse sovremennykh predstavlenii o sindrome sistemnogo vospalitel'nogo otveta. [Pathogenetic aspects of chronic placental insufficiency in the focus of modern ideas about the systemic inflammatory response syndrome]. Materialy V Rossiiskogo foruma «Mat' i ditya» [Proceedings of V Russian Forum «Mother and Child»]. M. 2003;29-30. (In Russ.).
Posiseeva LV, Panova IA, Sotnikova NYu, Kudryashova AV, Lukina NS. Early predictors of the nature of pregnancy in women with urogenital infection markers. Akusherstvo i ginekologiya. 2009;2:23-27. (In Russ.).
Sidel`nikova VM. Miscarriage — a modern view on the problem. Akusherstvo i ginekologiya. 2007;5:24-27. (In Russ.).
Sidorova IS, Makarov IO. Vnuyriutrobnaya infektsiya: diagnostika, profilaktika i lechenie: Posobie dlya vrachei. [Intrauterine infection: diagnosis, prevention and treatment: A guide for physicians antenatal. M.: MEDpress-Inform. 2008;31. (In Russ.).
Tyutyunik VL. The effect of infection on pregnancy, fetus and newborn. Vestnik Rossiiskoi assotsiatsii akusherov-ginekologov. 2001;1:20-23. (In Russ.).
Aleev IA. Whom to believe? On the need for a rational understanding of evidence-based medicine data. Status Praesents. 2012;3:9:52-55. (In Russ.).
Gazazyan MG, Stepanenko IV, Yudina SM. Prognozirovanie sostoyaniya novorozhdennykh u beremennykh s khronicheskoi genital'noi infektsiei. [Prediction of state of newborns of pregnant women with chronic genital infection]. Reproduktivnoe zdorov'e sem'i: Materialy Vtorogo Mezhdunarodnogo kongressa po reproduktivnoi meditsine. [Reproductive family health: Proceedings of the Second International Congress on reproductive medicine]. M. 2008;60. (In Russ.).
Dolgushina NV, Makatsaria AD. Endothelial damage and placental insufficiency in pregnant women with viral infections. Voprosy ginekologii, akusherstva i perinatologii. 2008;2:13-17. (In Russ.).
Podzolkova NM, Skvortsova MYu, Mel'nikova NI, Ostreikov IF. Intrauterine infection: current state of the problem. Akusherstvo i ginekologiya. 2009;3:27-32. (In Russ.).
Sukhikh GT, Vikhlyaeva EM, Van'ko LV, Khodzhaeva ZS, Shurshalina AV, Kholin AM. Endothelial dysfunction in the genesis of perinatal pathology. Akusherstvo i ginekologiya. 2008;5:3-5. (In Russ.).
Lamont RF. Infection in the prediction and antibiotics in the prevention of spontaneous preterm labour and preterm birth. BJOG. 2003;110:Suppl. 20:71-75. doi : 10.1046/j.1471-0528.2003.00034.x
Klein LL, Gibbs RS. Infection and preterm birth. Obstetrics and Gynecology Clinics. 2005;32:3:397-410. doi : 10.1016/j.ogc.2005.03.001
Le SYR, Leung CW. Histological chorioamnionitis for bacterial colonization, laboratory markers of infection, and early onset sepsis in very-low-birth-weight neonates. J of Maternal and Neonatal Medicine. 2012;25:4:364-368. doi: 10.3109/14767058.2011.579208
Tita AT, Andrews WW. Diagnosis and management of clinical chorioamnionitis. Clin Perinatol. 2010;37:2:339-354. doi : 10.1016/j.clp.2010.02.003

Close metadata