Specific features of cellular aging in women in different periods of life

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The paper reviews the data available in the literature on the problems of cellular aging in women in different periods of life and a relationship of their health factors, a cardiovascular risk, and telomere biology. It considers the possible factors of women’s health, which influence the development of cardiovascular diseases, type 2 diabetes mellitus, insulin resistance, metabolic syndrome, atherosclerosis, neurological, musculoskeletal diseases, etc. in women in different periods of life. These factors are age at menarche, miscarriage, artificial abortion, preterm delivery, preeclampsia, gestational diabetes, and menopause. The study results establishing the association of women’s health factors with the development of cardiovascular diseases are given. The paper also shows the role of estrogen deficiency in the development of cardiovascular diseases and its impact on telomerase activity and telomere length in postmenopausal women. The authors declare no conflicts of interest.

Keywords:

telomere biology

cardiovascular diseases

menarche

pregnancy complications

reproductive losses

insulin resistance

metabolic syndrome

Authors:

Lopatina O.V.

Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia

Balan V.E.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Tkacheva O.N.

Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia

ORCID: 0000-0002-4193-688X

Sharashkina N.V.

State Research Center for Preventive Medicine, Ministry of Health of Russia, Moscow, Russia

Zhuravel A.S.

Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia

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