To enhance the efficiency of surgical treatment for genital prolapse, a combined (laparovaginal) access and a prolene mesh were used to fix the uterus in 49 patients aged 45 to 72 years with internal genital descent and prolapse. They underwent clinical, laboratory, ultrasound, endoscopic studies, and 2-3-step combined (laparovaginal) surgery: vaginal colporrhaphy (Step 1), subsequent laparoscopic extraperitoneal supra-aponeurotic ventrofixation of the uterus with a prolene mesh (Step 2), and colpoperineorraphy with levatoroplasty (Step 3). A combination of three or more signs of connective tissue dysplasia was found in 28 (57.1%) patients. At surgery Steps 1 and 3, anterior and posterior colpoperineorraphy was performed in 22 patients, by applying the conventional procedure. At Step 2, all the patients underwent laparoscopic extraperitoneal supra-aponeurotic ventrofixation of the uterus with a prolene mesh. The total surgery duration was 25 to 75 min; that of laparoscopic ventrofixation was 25-35 min. No complications were observed in the postoperative period. The mean length of postoperative hospital stay was 5 to 9 days. Due to its low traumaticity, ease-to-use, short-term anesthesia, retroperitoneal mesh implantation, this procedure may be used in both young and postmenopausal patients, as well as in diabetic patients.