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Sidorova I.S.

Kafedra akusherstva i ginekologii #1 lechebnogo fakul'teta Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Unanian A.L.

Kafedra akusherstva i ginekologii #1

Zaletaev D.V.

Laboratoriia molekuliarnoĭ genetiki cheloveka NII molekuliarnoĭ meditsiny Pervogo moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova

Sha Sha

Kafedra akusherstva i ginekologii #1

Zholobova M.N.

Kafedra akusherstva i ginekologii #1 Pervogo Moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova

Vedernikova N.V.

Kafedra akusherstva i ginekologii #1 Pervogo Moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova

Role of genomic microsatellite instability in diseases of the cervix uteri in women with uterine myoma, adenomyosis, endometrial hyperplasia and their concomitance

Authors:

Sidorova I.S., Unanian A.L., Zaletaev D.V., Sha Sha, Zholobova M.N., Vedernikova N.V.

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Journal: Russian Bulletin of Obstetrician-Gynecologist. 2012;12(4): 13‑16

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Table of contents

ROLE OF GENOMIC MICROSATELLITE INSTABILITY IN DISEASES OF THE CERVIX UTERI IN WOMEN WITH UTERINE MYOMA, ADENOMYOSIS, ENDOMETRIAL HYPERPLASIA AND THEIR CONCOMITANCE
ROLE OF GENOMIC MICROSATELLITE INSTABILITY IN DISEASES OF THE CERVIX UTERI IN WOMEN WITH UTERINE MYOMA, ADENOMYOSIS, ENDOMETRIAL HYPERPLASIA AND THEIR CONCOMITANCE

To cite this article:

Sidorova IS, Unanian AL, Zaletaev DV, Sha Sha, Zholobova MN, Vedernikova NV. Role of genomic microsatellite instability in diseases of the cervix uteri in women with uterine myoma, adenomyosis, endometrial hyperplasia and their concomitance. Russian Bulletin of Obstetrician-Gynecologist. 2012;12(4):13‑16. (In Russ.)

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

To define the role of genomic microsatellite instability in cervix uteri pathology in women with uterine myoma, adenomyosis, endometrial hyperplasia, and their concomitance, the authors analyzed 116 genomes in the presence of benign and precancerous conditions of the cervix uteri from three microsatellite markers located at chromosomes 3р21.3, 5(q11.2-q13.3), 10(q23.2-q23.3). Analysis of genomic microsatellite instability revealed a statistically significant rise in its frequency in a series: benign cervical diseases (2.04%), CIN I (21.9%), CIN II (34.8%), and CIN III (91.7%), which bears witness to the involvement of microsatellite instability in the development of precancer of the cervix uteri.

Keywords:

genomic microsatellite instability
cervix uteri diseases
uterine myoma
adenomyosis
endometrial hyperplasia
concurrent uterine diseases

Authors:

Sidorova I.S.

Kafedra akusherstva i ginekologii #1 lechebnogo fakul'teta Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Unanian A.L.

Kafedra akusherstva i ginekologii #1

Zaletaev D.V.

Laboratoriia molekuliarnoĭ genetiki cheloveka NII molekuliarnoĭ meditsiny Pervogo moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova

Sha Sha

Kafedra akusherstva i ginekologii #1

Zholobova M.N.

Kafedra akusherstva i ginekologii #1 Pervogo Moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova

Vedernikova N.V.

Kafedra akusherstva i ginekologii #1 Pervogo Moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova

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References:

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