Assisted reproductive technologies (ART) were used to treat 204 infertile married couples. In 114 of them (a study group), 36 infertile patients suffered from polycystic ovary syndrome (PCOS), 38 had adenomyosis (Ad), and 40 had a history of 2 unsuccessful ART attempts or more. In this group, the endometrium was scraped under hysteroscopic guidance before superovulation stimulation in the in vitro fertilization (IVF) programs. A control group consisting of 3 subgroups (each has 30 infertile female patients) that had the above mentioned conditions, no hysteroscopy and endometrial scraping were carried out. Histological studies of the endometrium in the study group demonstrated its various pathological conditions in 61.1% of the patients with PCOS, 81.6% of those with Ad, and 87.5% of those who had a history of 2 unsuccessful ART attempts or more. In this group, pregnancy occurred due to therapy in 58.3% of the patients with PCOS, 47.4% of those with Ad, and 57.5% of those who had a history of 2 unsuccessful ART attempts or more. In the control group, pregnancy occurred in 30, 20, and 30%, respectively (p<0.05). The findings suggest that it is expedient to optimize the conditions of embryo implantation in the IVF programs, by scraping the endometrium under hysteroscopic guidance in patients of the above mentioned contingent.