The secretome of peripheral blood mononuclear cells in the therapy of patients with “thin” hypoplastic endometrium and infertility

Yakovlev A.A.; Erlikhman N.M.

doi:https://doi.org/10.17116/repro20243006181

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INTRODUCTION

The endometrium is a highly dynamic tissue that undergoes cyclic renewal in preparation for embryo implantation. Cyclic regeneration of the endometrium depends on the functional activity of the cell types that comprise it. The ability of the endometrium to quickly and repeatedly regenerate without scarring is unique, and a disrupted tissue renewal process can lead to infertility due to scarring or thin endometrium. The effectiveness of existing approaches to the treatment of thin endometrium is contradictory and requires the search for new optimal treatment directions. Scientific interest is the use of endogenous cell technologies to stimulate endometrial regeneration, such as platelet-rich plasma, peripheral blood mononuclear cells (PBMCs) and stem cells. The main therapeutic effects of these technologies by cells secreted paracrine factors (secretome). The isolated secretome from the cellular component retains functional activity and can be used as a finished medicinal product. Currently, the most accessible in production and use is the allogeneic and xenogenic secretome of PBMC (SPBMC).

OBJECTIVE

To define the SPBMC as a potential therapy for patients with «thin» hypoplastic endometrium and infertility.

MATERIAL AND METHODS

The sources of information were publications from the PubMed, Google Scholar, eLibrary.ru databases and in Russian specialized journals related to obstetrics and gynecology.

BASIC

The use of cellular technologies in the treatment of thin endometrium implies that the injected concentrated endogenous cells secrete bioactive factors (cytokines, chemokines, growth factors, proteins and extracellular vesicles, etc.) that participate in tissue regeneration.

These factors modulate biological processes that are crucial for tissue regeneration, such as angiogenesis, cell migration, and immunomodulation. Russian scientists were the first to use autogenic and xenogenic SPBMC as a medicinal product for therapeutic purposes.

More than 30 years of research confirm the regenerative effect of SPBMC, and the world’s only drug based on SPBMC shows worthy therapeutic results.

Using generalized literature data, the hypothesis about the benefits of SPBMC in the treatment of patients with thin endometrium and infertility is described.

CONCLUSION:

PBMC secretome as a finished drug may potentially increase endometrial thickness, pregnancy rate, and live birth in patients with thin endometrium and infertility. SPBMC may be as effective as other biological methods such as platelet-rich plasma, stem cells, or PBMC in terms of clinical efficacy, and may be a more affordable and safer alternative therapy.

Keywords:

peripheral blood mononuclear cells

peripheral blood mononuclear cell secretome

hypoplastic endometrium

infertility

Authors:

Yakovlev A.A.

LLC “Biotechfarm”

ORCID: 0009-0000-3062-2159

Erlikhman N.M.

LLC “Istochnik”;
LLC “EcoClinic” — Clinic “Istochnik”

ORCID: 0009-0002-7011-6888

Received:

10.09.2023

Accepted:

26.10.2024

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References:

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