This study reports the results of the comprehensive analysis of the data obtained during the examination of the tissues and organs of the maxillofacial region. The objective of the present study was to elucidate possible lesions in the maxillofacial tissues developing in the patients with hemoblastosis and to improve the quality of diagnostics, surgical and stomatological treatment of this pathology. Material and methods. The clinical examination involved 7 patients presenting with acute leukosis, 4 with lymphomas, 3 with multiple myeloma, 2 with chronic leukosis, 1 with plasmocytoma, and 1 with lymphpogranulomatosis. The mean age of the patients was 52 years. They were additionally examined with the use of CT, MRI, and ultrasound studies of the head and the neck. The results of laboratory investigations including clinical and biochemical analysis of blood as well as coagulograms were interpreted jointly with hematologists. The surgical stomatological treatment was provided for the patients presenting with concomitant odontogenic disorders. Results. The lesions of the maxillofacial tissues , such as erosion, ulceration, hemorrhages of oral cavity mucosa, and osteodestruction of facial bones, were documented in 66.6% of the patients with hemoblastosis, Six patients experienced the direct tumour growth (lymphoma and plasmocytoma) in the maxillofacial region. The concomitant odontogenic diseases (periodontitis and pathology of the temporomandibular joint) occurred in 11 patients or 61.1% of their total number. All pre-planned surgical interventions were conducted in the periods of remission of blood disease. A total of 7 (38.8%) patients were given the surgical treatment. In all the cases, the postoperative period passed uncomplicated. Conclusion. It is concluded that the knowledge of the symptoms of hemoblastosis in the maxillofacial region and the principles of surgical treatment of odontogenic pathological processes in the patients presenting with this condition may be helpful for the dental practitioners choosing the optimal variants of diagnostics and prescription of the adequate treatment. However, such treatment is likely to produce a favourable outcome only if provided based at a specialized hematological setting with the participation of an experienced hematologist.