Acute rhinosinusitis: treatment with a focus on key elements of pathogenesis

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OBJECTIVE

To summarize data on the efficacy and application prospects of combined preparation dimetindene + phenylephrine (Demephitsil) and azoximer bromide (Polyoxidonium) in comprehensive treatment of acute rhinosinusitis.

MATERIAL AND METHODS

The analysis of publications (articles and related abstracts), presented in the PubMed database, has been conducted. The material was searched according to following keywords: acute rhinitis, acute sinusitis, inflammation, phenylephrine and dimethindene, azoximer bromide.

RESULTS AND CONCLUSION

The published research results show that the use of dimetindene + phenylephrine (Demefecil) and azoximer bromide (Polyoxidonium) medicines allows to successfully control not only the symptoms of nasal obstruction due to inhibition of histamine expression, reduction of capillary permeability and transudation, but also the severity of inflammation process by immune disorders’ correction in patients with acute respiratory infection (rhinitis, sinusitis).

Keywords:

acute rhinitis

acute sinusitis

inflammation

phenylephrine and dimethindene

azoximer bromide

Authors:

Nosulya E.V.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

ORCID: 0000-0002-3897-8384

Kim I.A.

N.I. Pirogov Russian National Research Medical University;
National Medical Research Center of Otorhinolaryngology of Federal Medical-Biological Agency

ORCID: 0000-0003-1078-6388

Luchsheva Yu.V.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

ORCID: 0000-0002-8412-710X

Ogorodnikov D.S.

L.I. Sverzhevskiy Research Clinical Institute of Otorhinolaryngology;
N.I. Pirogov Russian National Research Medical University;
National Medical Research Center of Otorhinolaryngology

ORCID: 0000-0001-6086-1898

Accepted:

20.08.2023

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Получена 08.08.2023

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