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Nosulya E.V.
Sverzhevky Research Clinical Institute of Otorhinolaryngology
Kim I.A.
N.I. Pirogov Russian National Research Medical University;
National Medical Research Center of Otorhinolaryngology of Federal Medical-Biological Agency
Luchsheva Yu.V.
Sverzhevsky Research Clinical Institute of Otorhinolaryngology
Ogorodnikov D.S.
L.I. Sverzhevskiy Research Clinical Institute of Otorhinolaryngology;
N.I. Pirogov Russian National Research Medical University;
National Medical Research Center of Otorhinolaryngology
Acute rhinosinusitis: treatment with a focus on key elements of pathogenesis
Journal: Russian Rhinology. 2023;31(3): 212‑218
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To cite this article:
Nosulya EV, Kim IA, Luchsheva YuV, Ogorodnikov DS. Acute rhinosinusitis: treatment with a focus on key elements of pathogenesis. Russian Rhinology.
2023;31(3):212‑218. (In Russ.)
https://doi.org/10.17116/rosrino202331031212
To summarize data on the efficacy and application prospects of combined preparation dimetindene + phenylephrine (Demephitsil) and azoximer bromide (Polyoxidonium) in comprehensive treatment of acute rhinosinusitis.
The analysis of publications (articles and related abstracts), presented in the PubMed database, has been conducted. The material was searched according to following keywords: acute rhinitis, acute sinusitis, inflammation, phenylephrine and dimethindene, azoximer bromide.
The published research results show that the use of dimetindene + phenylephrine (Demefecil) and azoximer bromide (Polyoxidonium) medicines allows to successfully control not only the symptoms of nasal obstruction due to inhibition of histamine expression, reduction of capillary permeability and transudation, but also the severity of inflammation process by immune disorders’ correction in patients with acute respiratory infection (rhinitis, sinusitis).
Keywords:
Authors:
Nosulya E.V.
Sverzhevky Research Clinical Institute of Otorhinolaryngology
Kim I.A.
N.I. Pirogov Russian National Research Medical University;
National Medical Research Center of Otorhinolaryngology of Federal Medical-Biological Agency
Luchsheva Yu.V.
Sverzhevsky Research Clinical Institute of Otorhinolaryngology
Ogorodnikov D.S.
L.I. Sverzhevskiy Research Clinical Institute of Otorhinolaryngology;
N.I. Pirogov Russian National Research Medical University;
National Medical Research Center of Otorhinolaryngology
Accepted:
20.08.2023
List of references:
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