Chronic inflammation in case of obesity-associated diseases

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OBJECTIVE

To analyze the pathophysiological relationship of chronic inflammation with diseases associated with obesity.

MATERIALS AND METHODS

Search for published data was carried out in MedLine (PubMed) and eLibrary electronic databases.

RESULTS

A detailed analysis of the immune status change in obesity was performed. The main mechanisms of chronic inflammation development were presented (induction of a signal pathway induced by hypoxia-inducible factor 1 (HIF-1) due to local hypoxia, imbalance of populations of adipose tissue macrophages, accumulation of unfolded and misfolded endoplasmic reticulum proteins, activation of the NOD-like receptors family by dead and dying adipocytes).

The detailed characteristics of pro-inflammatory and anti-inflammatory adipokines was provided. The results of studies that demonstrated presence of relationship between chronic inflammation and development of associated diseases (arterial hypertension, autoimmune diseases (hypothyroidism, rheumatoid arthritis, psoriasis and psoriatic arthritis, osteoarthritis, inflammatory bowel diseases), atopic diseases and bronchial asthma, as well as oncological diseases) were presented.

CONCLUSION

Expansion of knowledge about chronic inflammation patterns and mediators is important for the development of new methods to treat obesity and associated allergic, autoimmune and neoplastic diseases.

Keywords:

obesity

chronic inflammation

adipokines

hypothyroidism

arterial hypertension

bronchial asthma

oncological diseases

Authors:

Kim O.T.

National Medical Research Center for Therapy and Preventive Medicine

ORCID: 0000-0002-0332-7696

Dadaeva V.A.

National Medical Research Center for Therapy and Preventive Medicine

ORCID: 0000-0002-0348-4480

Nurullina G.I.

Kazan State Medical University

ORCID: 0000-0002-7697-187X

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine;
Russian University of Medicine

SPIN RSCI: 4456-1297
Scopus AuthorID: 57208852308
ResearcherID: G-8443-2016
ORCID: 0000-0002-4453-8430

Received:

23.09.2024

Accepted:

30.09.2024

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