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Eliashevich S.O.

National Medical Research Centre of Therapy and Preventive Medicine

Zimina P.A.

National Medical Research Center for Therapy and Preventive Medicine

Orekhova A.V.

National Medical Research Center for Therapy and Preventive Medicine

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Potential for the use of nutraceuticals for hyperlipidemia correction

Authors:

Eliashevich S.O., Zimina P.A., Orekhova A.V., Drapkina O.M.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2025;28(3): 40‑45

DOI: 10.17116/profmed20252803140

Read: 1664 times

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Table of contents

POTENTIAL FOR THE USE OF NUTRACEUTICALS FOR HYPERLIPIDEMIA CORRECTION
POTENTIAL FOR THE USE OF NUTRACEUTICALS FOR HYPERLIPIDEMIA CORRECTION

To cite this article:

Eliashevich SO, Zimina PA, Orekhova AV, Drapkina OM. Potential for the use of nutraceuticals for hyperlipidemia correction. Russian Journal of Preventive Medicine. 2025;28(3):40‑45. (In Russ.)
https://doi.org/10.17116/profmed20252803140

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Lipid storage disorders are one of the risk factors for systemic atherosclerotic process development. One of important aspects of hyperlipidemia treatment is non-drug methods, including lifestyle changes and the use of nutraceuticals.

OBJECTIVE

To analyze current data on the efficacy and safety of the dietary food supplements use for hyperlipidemia correction.

MATERIALS AND METHODS

Search and analysis of literature reviews and original articles from PubMed and eLibrary databases published between 2016 and May 2024 were performed. The following keywords were used: nutraceuticals, hyperlipidemia. A number of full-text publications equal 47 was selected. The review also presents primary sources covering studies of dietary food supplements dated earlier than 2016, as they contain valuable information.

RESULTS

Red yeast rice (monacolin), phytosterols, omega-3 fatty acids, dietary fibers were used as functional food ingredients widely studied in hyperlipidemia. Efficacy of a given nutraceutical varies and is in the range of minus 5% to 25% of the baseline low-density lipoprotein cholesterol level. Data on side effects, related to both the action of biologically active agent itself and the lack of standardization and presence of undesirable impurities in the composition were obtained.

CONCLUSION

Change in dietary pattern for primary prevention can be used in persons with low/moderate or high cardiovascular risk in low-density lipoprotein cholesterol level ranging from 1.8 to 2.6 mmol/L in the absence of indications for taking statins and/or at doctor’s discretion. Despite the positive effects of nutraceuticals administration, it is important to remember that they cannot replace lipid-lowering therapy, but have the potential to reduce residual cardiovascular risk.

Keywords:

nutraceuticals
hyperlipidemia
dietary food supplements
red yeast rice
phytosterols
dietary fibers
omega-3

Authors:

Eliashevich S.O.

National Medical Research Centre of Therapy and Preventive Medicine

Zimina P.A.

National Medical Research Center for Therapy and Preventive Medicine

Orekhova A.V.

National Medical Research Center for Therapy and Preventive Medicine

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Received:

12.09.2024

Accepted:

23.09.2024

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