OBJECTIVE

To study the prognostic value of different indicators as markers of adverse outcomes in patients with stable coronary heart disease (CHD) after scheduled percutaneous coronary interventions.

MATERIAL AND METHODS

The prospective study included 74 patients (58 females and 16 males) diagnosed with stable CHD who underwent a percutaneous coronary intervention (PCI). The average age of the patients was 65 (59;71) years. The endpoints analyzed after 16 (9; 22) months included general and cardiovascular death, non-fatal myocardial infarction, non-fatal acute cerebrovascular accident, hospitalization for decompensation of chronic heart failure (CHF), unstable angina, as well as an integrated endpoint combining all the adverse outcomes listed above.

RESULTS

The endpoints were analyzed after 16 (9; 22) months. The adverse outcomes structure was dominated by non-fatal acute cerebrovascular accidents — in 8 (29.6%) patients, hospitalization for CHF decompensation and restenosis of previously installed stents — in 7 (25.9%) patients each, and fatal outcome — in 5 (18.5%) patients. The multivariate Cox regression analysis showed that only the NGAL level was a significant independent predictor of adverse events: HR — 1.020, 95% CI 1.002—1.037, p=0.031. So, an increase in the NGAL level by 1 ng/mL increases the risk of an earlier outcome by 2%.

CONCLUSION

The results obtained prove that only the NGAL level out of all studied indicators has an unfavorable impact on the prognosis. An increase in the NGAL level by 1 ng/mL increases the risk of an earlier outcome by 2%.