The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Nikitina N.M.
Saratov State Medical University named after V.I. Razumovsky
Bogdalova L.R.
Saratov State Medical University named after V.I. Razumovsky
Ziyadullaev Sh.Kh.
Samarkand State Medical University
Rebrov A.P.
Saratov State Medical University named after V.I. Razumovsky
The effectiveness of therapy and the quality of life of patients with rheumatoid arthritis depending on the baseline treatment adherence
Journal: Russian Journal of Preventive Medicine. 2023;26(5): 78‑84
Views: 1652
Downloaded: 57
To cite this article:
Nikitina NM, Egorova EV, Bogdalova LR, Ziyadullaev ShKh, Rebrov AP. The effectiveness of therapy and the quality of life of patients with rheumatoid arthritis depending on the baseline treatment adherence. Russian Journal of Preventive Medicine.
2023;26(5):78‑84. (In Russ.)
https://doi.org/10.17116/profmed20232605178
Treatment adherence is an essential component of the effectiveness of therapy and the preservation of a good quality of life.
To evaluate the real-world effectiveness of therapy and quality of life (QoL) of patients with rheumatoid arthritis (RA) after one year of follow-up, depending on baseline compliance.
The study included 132 females with confirmed RA (age 55.5±10.5 years, duration of RA 10.2 [4; 14] years), with moderate and high activity of RA (DAS 28 score of 5.0 [4.3; 5.8]). Clinical and laboratory examination was conducted: QoL assessment using HAQ questionnaire and EQ-5D. Pain was assessed on a visual analog scale (VAS), treatment adherence was evaluated using the questionnaire for qualitative assessment of adherence to Morisky-Green and the QAA-25 — questionnaire for quantitative assessment of adherence (according to N.A. Nikolaev). In 60 patients comparable in baseline characteristics of the disease with different levels of adherence, the examinations were carried out at baseline and after a year.
Low treatment adherence was shown by the Morisky-Green questionnaire in 68 (52.3%) of 132 and by the QAA-25 questionnaire in 33 (40.3%) of 82 females with RA. The least adherence to the recommendations for lifestyle modification was noted. Predictors of high treatment adherence were the young age of patients, a shorter duration of the disease, and a lower level of pain according to VAS. In patients with RA with initially low adherence to treatment after a year, an increase in the disease activity and a decrease in quality of life were noted, despite the therapy.
The relationships we have identified between baseline adherence, disease activity, and quality of life after one year of follow-up demonstrate the importance of considering baseline adherence. The least adherence was to lifestyle changes. Further research is needed on the factors affecting overall adherence and its components. The development of methods to increase treatment adherence can improve the effectiveness of therapy and the quality of life of patients with rheumatoid arthritis.
Authors:
Nikitina N.M.
Saratov State Medical University named after V.I. Razumovsky
Bogdalova L.R.
Saratov State Medical University named after V.I. Razumovsky
Ziyadullaev Sh.Kh.
Samarkand State Medical University
Rebrov A.P.
Saratov State Medical University named after V.I. Razumovsky
Received:
14.11.2022
Accepted:
08.02.2023
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.