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Tolpygina S.N.

National Medical Research Center for Therapy and Preventive Medicine

Zagrebelny A.V.

National Medical Research Center for Therapy and Preventive Medicine

Chernysheva M.I.

City Polyclinic No. 218

Kutishenko N.P.

National Medical Research Center for Therapy and Preventive Medicine

Lukina Yu.V.

National Medical Research Center for Therapy and Preventive Medicine

Voronina V.P.

National Medical Research Center for Therapy and Preventive Medicine

Dmitrieva N.A.

National Medical Research Center for Therapy and Preventive Medicine

Lerman O.V.

National Medical Research Center for Therapy and Preventive Medicine

Loukianov M.M.

National Medical Research Center for Therapy and Preventive Medicine

Okshina E.Yu.

National Medical Research Center for Therapy and Preventive Medicine

Parsadanyan N.E.

City Polyclinic No. 218

Martsevich S.Yu.

National Medical Research Center for Therapy and Preventive Medicine

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Comorbidity and long-term survival of patients suffered from acute cerebrovascular accident based on the REGION-M registry

Authors:

Tolpygina S.N., Zagrebelny A.V., Chernysheva M.I., Kutishenko N.P., Lukina Yu.V., Voronina V.P., Dmitrieva N.A., Lerman O.V., Loukianov M.M., Okshina E.Yu., Parsadanyan N.E., Martsevich S.Yu., Drapkina O.M.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2023;26(11): 64‑68

DOI: 10.17116/profmed20232611164

Views: 764

Downloaded: 31

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To cite this article:

Tolpygina SN, Zagrebelny AV, Chernysheva MI, et al. . Comorbidity and long-term survival of patients suffered from acute cerebrovascular accident based on the REGION-M registry. Russian Journal of Preventive Medicine. 2023;26(11):64‑68. (In Russ.)
https://doi.org/10.17116/profmed20232611164

Подписка 2025 (Russian Journal of Preventive Medicine)
 
МСФ на ЯМ
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OBJECTIVE

To study the impact of comorbid diseases on long-term survival of patients who have suffered acute cerebrovascular accident (ACVA/CVA).

MATERIAL AND METHODS

REGION-M outpatient register included 684 patients with confirmed ACVA (stroke or transitory ischemic attack) diagnosis attached to City Polyclinic №218, signed out from Inozemtsev City Clinical Hospital for the period from 01.01.12 yr. to 30.04.17 yr. The outpatient observation stage from 2017 to 2022 yr. was equal 5.5 (2.4—7.0) years. «Death from all causes» was chosen as a final point.

RESULTS

In single-factor analysis, the presence of ischemic heart disease (p<0.0001), previous myocardial infarction (p<0.0001), the presence of diabetes mellitus (p<0.05) and obesity (p<0.01) had a negative effect on the prognosis. In multi-factor analysis, including in addition to comorbid diseases, sex and age, only myocardial infarction in the history (RA of death 1.009 (95% CI 1.004—1.014, p<0.001) retained statistical significance.

CONCLUSION

In patients who have suffered acute cerebrovascular accident the presence of myocardial infarct in the history worsened the long-term survival

Keywords:

cerebrovascular accident
comorbid diseases
register
long-term survival
mortality

Authors:

Tolpygina S.N.

National Medical Research Center for Therapy and Preventive Medicine

Zagrebelny A.V.

National Medical Research Center for Therapy and Preventive Medicine

Chernysheva M.I.

City Polyclinic No. 218

Kutishenko N.P.

National Medical Research Center for Therapy and Preventive Medicine

Lukina Yu.V.

National Medical Research Center for Therapy and Preventive Medicine

Voronina V.P.

National Medical Research Center for Therapy and Preventive Medicine

Dmitrieva N.A.

National Medical Research Center for Therapy and Preventive Medicine

Lerman O.V.

National Medical Research Center for Therapy and Preventive Medicine

Loukianov M.M.

National Medical Research Center for Therapy and Preventive Medicine

Okshina E.Yu.

National Medical Research Center for Therapy and Preventive Medicine

Parsadanyan N.E.

City Polyclinic No. 218

Martsevich S.Yu.

National Medical Research Center for Therapy and Preventive Medicine

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Received:

10.07.2023

Accepted:

01.08.2023

List of references:

  1. Drapkina OM, Kontsevaya AV, Kalinina AM, et al. 2022 Prevention of chronic non-communicable diseases in the Russian Federation. National guidelines. Kardiovaskuljarnaja terapija i profilaktika. 2022;21(4):3235. (In Russ.). https://doi.org/10.15829/1728-8800-2022-3235
  2. Benjamin EJ, Blaha MJ, Chiuve SE, et al; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics 2017 Update: A Report from the American Heart Association. Circulation. 2017;135(10):146-603.  https://doi.org/10.1161/CIR.0000000000000485
  3. Martsevich SYu, Kutishenko NP, Suvorov AYu, et al. The study of anamnestic factors and their role in estimation of short-term (in-hospital) prognosis in patient underwent brain stroke or transient ischemic attack, by the data LIS-2 registry. Rossijskij kardiologicheskij zhurnal. 2015;6(122):14-19. (In Russ). https://doi.org/10.15829/1560-4071-2015-6-14-19
  4. Boytsov SA, Martsevich SYu, Ginzburg ML, et al. Lyubertsy study on mortality rate in patients after cerebral stroke or transient ischemic attack (LIS-2). Design and medical treatment estimation. Racional’naja farmakoterapija v kardiologii. 2013;9(2):114-122. (In Russ.). https://doi.org/10.20996/1819-6446-2013-9-2-114-122
  5. Benjamin EJ, Muntner P, Alonso A, et al; American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics — 2019 Update: A Report from the American Heart Association. Circulation. 2019;139(10):56-528.  https://doi.org/10.1161/CIR.0000000000000659
  6. Tolpygina SN, Martsevich SYu, Deev AD. The influence of concomitant diseases on a long-term prognosis in patients with chronic ischemic heart disease according to the PROGNOZ IBS register. Racional’naja farmakoterapija v kardiologii. 2015;11(6):571-576. (In Russ.). https://doi.org/10.20996/1819-6446-2015-11-6-571-576
  7. Voronina VP, Zagrebelnyi AV, Lukina YuV, et al. Features of cerebral stroke course in patients with diabetes mellitus according to the REGION-M register. Kardiovaskuljarnaja terapija i profilaktika. 2019;18(5):60-65. (In Russ.). https://doi.org/10.15829/1728-8800-2019-5-60-65
  8. Tolpygina SN, Zagrebelny AV, Chernysheva MI, et al. Long-term survival of patients after cerebrovascular accident with prior coronary artery disease: data from the outpatient stage of REGION-M registry. Kardiovaskuljarnaja terapija i profilaktika. 2022;21(8):3288. (In Russ.). https://doi.org/10.15829/1728-8800-2022-3288
  9. Tolpygina SN, Zagrebelny AV, Chernysheva MI, et al. Long-term survival of patients with cerebrovascular accident in different age groups in the REGION-M registry. Rossijskij kardiologicheskij zhurnal. 2023;28(2):5250. (In Russ.). https://doi.org/10.15829/1560-4071-2023-5250
  10. Arauz A, Marquez-Romero JM, Barboza MA, et al. Mexican-National Institute of Neurology and Neurosurgery-Stroke Registry: Results of a 25-Year Hospital-Based Study. Frontiers in Neurology. 2018;9:207.  https://doi.org/10.3389/fneur.2018.00207
  11. Martsevich SYu, Tolpygina SN, Chernysheva MI, et al. Adherence to attendance at outpatient clinic and longterm survival of patients after stroke in outpatient setting: the data of REGIOM-M registry. Racional’naja farmakoterapija v kardiologii. 2021;3(17):386-393. (In Russ.). https://doi.org/10.20996/1819-6446-2021-06-04
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  13. Task Force Members; Montalescot G, Sechtem U, Achenbach S, et al. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. European Heart Journal. 2013;34(38):2949-3003. https://doi.org/10.1093/eurheartj/eht296
  14. Boytsov SA, Luk’yanov MM, Yakushin SS, et al. Outpatient register of cardiovascular diseases in the Ryazan Region (RECVASA): principal tasks, experience of development and first results. Kardiovaskuljarnaja terapija i profilaktika. 2014;13(6):44-50. (In Russ.). https://doi.org/10.15829/1728-8800-2014-6-3-8

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