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Drapkina O.M.
National Medical Research Center for Therapy and Preventive Medicine;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Zhamalov L.M.
National Medical Research Center for Therapy and Preventive Medicine
Gut microbiota: a new risk factor for atherosclerosis?
Journal: Russian Journal of Preventive Medicine. 2022;25(11): 92‑97
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To cite this article:
Drapkina OM, Zhamalov LM. Gut microbiota: a new risk factor for atherosclerosis?. Russian Journal of Preventive Medicine.
2022;25(11):92‑97. (In Russ.)
https://doi.org/10.17116/profmed20222511192
Cardiovascular diseases (CVDs) are the leading cause of death worldwide and continue to rise steadily, even though the traditional risk factors for CVDs are well understood. The pathogenesis of most CVDs is based on atherosclerosis. Many previously overlooked factors play a role in atherosclerosis development and progression. Over the past two decades, evidence has accumulated for the effect of the gut microbiota (GM) and its several metabolites on atherosclerosis and CVD development. This review describes the mechanisms of the effects of GM and its metabolites, such as trimethylamine N-oxide, lipopolysaccharide, and short-chain fatty acids (SCFAs), on lipid metabolism and atherosclerosis development and progression. The potential use of various GM metabolites as biomarkers of cardiovascular risk, which could improve the accuracy of risk assessment compared with existing models, is discussed. The review addresses the studied associations of various GM representatives with the CVD risk and the prospects of affecting GM and its metabolites to reduce such risk, in particular, transplantation of fecal microbiota and use of probiotics and prebiotics.
Authors:
Drapkina O.M.
National Medical Research Center for Therapy and Preventive Medicine;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Zhamalov L.M.
National Medical Research Center for Therapy and Preventive Medicine
Received:
15.08.2022
Accepted:
23.08.2022
List of references:
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