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Khoroshunova E.A.

Siberian State Medical University

Samoilova Y.G.

Siberian State Medical University

Matveeva M.V.

Siberian State Medical University

Kudlay D.A.

Institute of Immunology;
Sechenov First Moscow State Medical University (Sechenov University)

Miroshnichenko A.I.

Siberian State Medical University

Mosienko I.V.

Siberian State Medical University

Yun V.E.

Siberian State Medical University

Trifonova E.I.

Siberian State Medical University

Zakharchuk P.I.

Siberian State Medical University

Vachadze T.D.

Siberian State Medical University

Shuliko L.M.

Siberian State Medical University

Galyukova D.E.

Siberian State Medical University

Mutalimi V.E.

Siberian State Medical University

Current methods for sarcopenia diagnosis in patients with impaired carbohydrate metabolism

Authors:

Khoroshunova E.A., Samoilova Y.G., Matveeva M.V., Kudlay D.A., Miroshnichenko A.I., Mosienko I.V., Yun V.E., Trifonova E.I., Zakharchuk P.I., Vachadze T.D., Shuliko L.M., Galyukova D.E., Mutalimi V.E.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2022;25(10): 116‑121

DOI: 10.17116/profmed202225101116

Read: 2594 times

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Table of contents

CURRENT METHODS FOR SARCOPENIA DIAGNOSIS IN PATIENTS WITH IMPAIRED CARBOHYDRATE METABOLISM
CURRENT METHODS FOR SARCOPENIA DIAGNOSIS IN PATIENTS WITH IMPAIRED CARBOHYDRATE METABOLISM

To cite this article:

Khoroshunova EA, Samoilova YG, Matveeva MV, et al. . Current methods for sarcopenia diagnosis in patients with impaired carbohydrate metabolism. Russian Journal of Preventive Medicine. 2022;25(10):116‑121. (In Russ.)
https://doi.org/10.17116/profmed202225101116

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The progressive increase in the number of elderly people is an important achievement of modern medicine. Patients of this category have a high incidence of comorbidities and reduced muscle mass and strength — sarcopenia. The incidence of non-communicable diseases is increasing, with diabetes mellitus (DM) and obesity being the most common. The main category of patients with impaired carbohydrate metabolism is represented by middle-aged and elderly patients. The combination of sarcopenia and obesity increases the risk of arterial hypertension, type 2 DM, cardiovascular diseases, and the risk of death in this group. In addition, the progressive reduction of muscle mass aggravates the course of DM, leading to the early development of complications, prolonged specialized hospital stay, and increased economic costs. Currently, there is no unified diagnostic algorithm, and there are no «gold standard» biomarkers for sarcopenia, causing the diagnosis delay. The clinical course, social and economic aspects of this condition have been extensively studied over the last decades, while the problem of sarcopenia is poorly represented in the Russian-language literature, and there are no large-scale studies evaluating the relationship between decreased muscle mass and impaired carbohydrate metabolism. This article addresses the terminology, pathophysiological aspects, and diagnostic criteria for sarcopenia based on the publications in eLibrary, Scopus, and WoS databases for the last 15 years.

Keywords:

sarcopenia
sarcopenic obesity
biomarkers
oxidative stress

Authors:

Khoroshunova E.A.

Siberian State Medical University

Samoilova Y.G.

Siberian State Medical University

Matveeva M.V.

Siberian State Medical University

Kudlay D.A.

Institute of Immunology;
Sechenov First Moscow State Medical University (Sechenov University)

Miroshnichenko A.I.

Siberian State Medical University

Mosienko I.V.

Siberian State Medical University

Yun V.E.

Siberian State Medical University

Trifonova E.I.

Siberian State Medical University

Zakharchuk P.I.

Siberian State Medical University

Vachadze T.D.

Siberian State Medical University

Shuliko L.M.

Siberian State Medical University

Galyukova D.E.

Siberian State Medical University

Mutalimi V.E.

Siberian State Medical University

Received:

26.05.2022

Accepted:

06.08.2022

Close metadata

References:

  1. Misnikova IV, Kovaleva YuA, Klimina N.A. Sarkopenic obesity. RMZH. 2017;25(1):24-29. (In Russ.).
  2. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis. Age and Ageing. 2010;39(4):412-423.  https://doi.org/10.1093/ageing/afq034
  3. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing. 2019;48(4):601.  https://doi.org/10.1093/ageing/afz046
  4. Yakabe M, Ogawa S, Akishita M. Clinical Manifestations and Pathophysiology of Sarcopenia. RNA and Transcription. 2015;1(2):10. 
  5. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing. 2019;48(1):16-31. 
  6. Hirose S, Nakajima T, Nozawa N, et al. Phase Angle as an Indicator of Sarcopenia, Malnutrition, and Cachexia in Inpatients with Cardiovascular Diseases. Journal of Clinical Medicine. 2020;9(8):2554. https://doi.org/10.3390/jcm9082554
  7. Uemura K, Doi T, Tsutsumimoto K, et al. Predictivity of bioimpedance phase angle for incident disability in older adults. Journal of Cachexia, Sarcopenia and Muscle. 2020;11(1):46-54.  https://doi.org/10.1002/jcsm.12492
  8. Kurmaev DP, Bulgakova SV, Zakharova NO. Bioimpedance phase angle as a marker of sarcopenia in women of senile age with polymorbid pathology. Al’manah klinicheskoj mediciny. 2021;49(4):245-253. (In Russ.). https://doi.org/10.18786/2072-0505-2021-49-026
  9. Ko SJ, Cho J, Choi SM, et al. Phase Angle and Frailty Are Important Prognostic Factors in Critically Ill Medical Patients: A Prospective Cohort Study. The Journal of Nutrition, Health and Aging. 2021;25(2):218-223.  https://doi.org/10.1007/s12603-020-1487-0
  10. Pareja-Galeano H, Sanchis-Gomar F, Pérez LM, et al. iPSCs-based anti-aging therapies: Recent discoveries and future challenges. Ageing Research Reviews. 2016;27:37-41.  https://doi.org/10.1016/j.arr.2016.02.007
  11. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nature Reviews. Immunology. 2011;11(2):85-97.  https://doi.org/10.1038/nri2921
  12. Wong WL, Su X, Li X, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. The Lancet. Global Health. 2014;2(2):106-116.  https://doi.org/10.1016/S2214-109X(13)70145-1
  13. Chau BK, Kolling N, Hunt LT, Walton ME, Rushworth MF. A neural mechanism underlying failure of optimal choice with multiple alternatives. Nature Neuroscience. 2014;17(3):463-470.  https://doi.org/10.1038/nn.3649
  14. Ma Q, Li W, Thorne RM, et al. Modeling inward diffusion and slow decay of energetic electrons in the Earth’s outer radiation belt. Geophysical Research Letters. 2015;42(4):987-995.  https://doi.org/10.1002/2014GL062977
  15. Mathieu S, Sabóia Aragão K, Imberty A, Varrot A. Discoidin I from Dictyostelium discoideum and Interactions with oligosaccharides: specificity, affinity, crystal structures, and comparison with discoidin II. Journal of Molecular Biology. 2010;400(3):540-554.  https://doi.org/10.1016/j.jmb.2010.05.042
  16. Yang L, Eyal E, Chennubhotla C, et al. Insights into Equilibrium Dynamics of Proteins from Comparison of NMR and X-Ray Data with Computational Predictions. Structure. 2007;15(6):741-749.  https://doi.org/10.1016/j.str.2007.04.014
  17. Liesa M, Shirihai OS. Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metabolism. 2013;17(4):491-506.  https://doi.org/10.1016/j.cmet.2013.03.002
  18. Kim TN, Park MS, Yang SJ, et al. Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes: the Korean Sarcopenic Obesity Study (KSOS). Diabetes Care. 2010;33(7):1497-1499. https://doi.org/10.2337/dc09-2310
  19. Park SW, Goodpaster BH, Lee JS, et al. Health, Aging, and Body Composition Study. Excessive loss of skeletal muscle mass in older adults with type 2 diabetes. Diabetes Care. 2009;32(11):1993-1997. https://doi.org/10.2337/dc09-0264
  20. Franceschi C, Bonafè M, Valensin S, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Annals of the New York Academy of Sciences. 2000;908:244-254.  https://doi.org/10.1111/j.1749-6632.2000.tb06651.x
  21. Boren E, Gershwin ME. Inflamm-aging: autoimmunity, and the immune-risk phenotype. Autoimmunity Reviews. 2004;3(5):401-406.  https://doi.org/10.1016/j.autrev.2004.03.004
  22. Franceschi C, Valensin S, Lescai F, et al. Neuroinflammation and the genetics of Alzheimer’s disease: the search for a pro-inflammatory phenotype. Aging. 2001;13(3):163-170.  https://doi.org/10.1007/BF03351475
  23. Giunta B, Fernandez F, Nikolic WV, et al. Inflammaging as a prodrome to Alzheimer’s disease. Journal of Neuroinflammation. 2008;5:51.  https://doi.org/10.1186/1742-2094-5-51
  24. De Martinis M, Franceschi C, Monti D, Ginaldi L. Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Letters. 2005;579(10):2035-2039. https://doi.org/10.1016/j.febslet.2005.02.055
  25. Cesari M, Penninx BW, Pahor M, et al. Inflammatory markers and physical performance in older persons: the InCHIANTI study. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2004;59(3):242-248.  https://doi.org/10.1093/gerona/59.3.m242
  26. Calvani R, Picca A, Marini F, et al. Identification of biomarkers for physical frailty and sarcopenia through a new multi-marker approach: Results from the Biosphere study. GeroScience. 2021;43(2):727-740.  https://doi.org/10.1007/s11357-020-00197-x
  27. Baum J, Duffy HS. Fibroblasts and myofibroblasts: What are we talking about? Journal of Cardiovascular Pharmacology. 2011;57(4):376-379.  https://doi.org/10.1097/FJC.0b013e3182116e39
  28. Tidball JG, Villalta SA. Regulatory interactions between muscle and the immune system during muscle regeneration. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2010;298(5):1173-1187. https://doi.org/10.1152/ajpregu.00735.2009
  29. Lemos DR, Babaeijandaghi F, Low M, et al. Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors. Nature Medicine. 2015;21(7):786-794.  https://doi.org/10.1038/nm.3869
  30. Mukund K, Subramaniam S. Skeletal muscle: A review of molecular structure and function, in health and disease. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 2020;12(1):e1462. https://doi.org/10.1002/wsbm.1462
  31. Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. Ageing Research Reviews. 2008; 7(2):83-105.  https://doi.org/10.1016/j.arr.2007.09.002
  32. Dai L, Liu D, Guo H, Wang Y, Bai Y. Association between polymorphism in the promoter region of interleukin 6 (−174G/C) and risk of Alzheimer’s disease: a meta-analysis. Journal of Neurology. 2012;259(3):414-419.  https://doi.org/10.1007/s00415-011-6164-0
  33. Hou H, Wang C, Sun F, Zhao L, Dun A, Sun Z. Association of interleukin-6 gene polymorphism with coronary artery disease: an updated systematic review and cumulative meta-analysis. Inflammation Research. 2015; 64(9):707-720.  https://doi.org/10.1007/s00011-015-0850-9
  34. Testa R, Olivieri F, Bonfigli AR, et al. Interleukin-6—174 G>C polymorphism affects the association between IL-6 plasma levels and insulin resistance in type 2 diabetic patients. Diabetes Research and Clinical Practice. 2006;71(3):299-305.  https://doi.org/10.1016/j.diabres.2005.07.007
  35. Moffett SP, Zmuda JM, Cauley JA, et al. Association of the G-174C variant in the interleukin-6 promoter region with bone loss and fracture risk in older women. Journal of Bone and Mineral Research. 2004;19(10):1612-1618. https://doi.org/10.1359/JBMR.040707
  36. Fishman D, Faulds G, Jeffery R, et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. The Journal of Clinical Investigation. 1998;102(7):1369-1376. https://doi.org/10.1172/JCI2629
  37. Zeng Y, Nie C, Min J, et al. Novel loci and pathways significantly associated with longevity. Scientific Reports. 2016;6:21243. https://doi.org/10.1038/srep21243
  38. Di Marco S, Mazroui R, Dallaire P, et al. NF-kappa B-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release. Molecular and Cellular Biology. 2005;25(15):6533-6545. https://doi.org/10.1128/MCB.25.15.6533-6545.2005
  39. Hall DT, Ma JF, Marco SD, Gallouzi IE. Inducible nitric oxide synthase (iNOS) in muscle wasting syndrome, sarcopenia, and cachexia. Aging. 2011; 3(8):702-715.  https://doi.org/10.18632/aging.100358
  40. Schaap LA, Pluijm SM, Deeg DJ, Visser M. Inflammatory markers and loss of muscle mass (sarcopenia) and strength. The American Journal of Medicine. 2006;119(6):526.e9-526.e5.26E17. https://doi.org/10.1016/j.amjmed.2005.10.049
  41. Bencze M, Negroni E, Vallese D, et al. Proinflammatory macrophages enhance the regenerative capacity of human myoblasts by modifying their kinetics of proliferation and differentiation. Molecular Therapy. 2012;20(11): 2168-2179. https://doi.org/10.1038/mt.2012.189
  42. Peters MJ, Joehanes R, Pilling LC, et al. The transcriptional landscape of age in human peripheral blood. Nature Communications. 2015;6:8570. https://doi.org/10.1038/ncomms9570
  43. Grosicki GJ, Fielding RA, Lustgarten MS. Gut Microbiota contribute to age-related changes in skeletal muscle size, composition, and function: Biological basis for a gut-muscle axis. Calcified Tissue International. 2018; 102(4):433-442.  https://doi.org/10.1007/s00223-017-0345-5
  44. Ticinesi A, Lauretani F, Milani C, et al. Aging gut microbiota at the cross-road between nutrition, physical frailty, and sarcopenia: Is there a gut-muscle axis? Nutrients. 2017;9(12):1303. https://doi.org/10.3390/nu9121303
  45. O’Toole PW, Jeffery IB. Gut microbiota and aging. Science. 2015;350(6265): 1214-1215. https://doi.org/10.1126/science.aac8469
  46. Stecher B, Hardt W-D. The role of microbiota in infectious disease. Trends in Microbiology. 2008;16(3):107-114.  https://doi.org/10.1016/j.tim.2007.12.008
  47. MacPherson AJ, Geuking MB, McCoy KD. Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria. Immunology. 2005; 115(2):153-162.  https://doi.org/10.1111/j.1365-2567.2005.02159.x
  48. Bäckhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(3):979-984.  https://doi.org/10.1073/pnas.0605374104
  49. Peng L, Li ZR, Green RS, Holzman IR, Lin J. Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. The Journal of Nutrition. 2009;139(9):1619-1625. https://doi.org/10.3945/jn.109.104638
  50. Picca A, Ponziani FR, Calvani R, et al. Gut microbial, inflammatory and metabolic signatures in older people with physical frailty and sarcopenia: Results from the Biosphere study. Nutrients. 2019;12(1):65.  https://doi.org/10.3390/nu12010065
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