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Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Berns S.A.

Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of Russia

Gorshkov A.Yu.

National Medical Research Center for Therapy and Preventive Medicine

Yavelov I.S.

National Medical Research Center for Therapy and Preventive Medicine

Shishkova V.N.

National Medical Research Center for Therapy and Preventive Medicine Federal State Budgetary Institution the Ministry of Health of Russia;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry Federal State Budgetary Educational Institution of Higher Education

Ryzhakova L.N.

National Medical Research Center for Therapy and Preventive Medicine

Ivanova A.A.

Federal Scientific Clinical Center for Children and Adolescents

Veretennikova A.V.

National Medical Research Center for Therapy and Preventive Medicine

Karateev R.A.

National Medical Research Center for Therapy and Preventive Medicine

Arablinskiy N.A.

National Medical Research Center for Therapy and Preventive Medicine

Thrombodynamics parameters in individuals vaccinated against SARS-CoV-2

Authors:

Drapkina O.M., Berns S.A., Gorshkov A.Yu., Yavelov I.S., Shishkova V.N., Ryzhakova L.N., Ivanova A.A., Veretennikova A.V., Karateev R.A., Arablinskiy N.A.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2021;24(12): 24‑30

DOI: 10.17116/profmed20212412124

Read: 1877 times

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Table of contents

THROMBODYNAMICS PARAMETERS IN INDIVIDUALS VACCINATED AGAINST SARS-COV-2
THROMBODYNAMICS PARAMETERS IN INDIVIDUALS VACCINATED AGAINST SARS-COV-2

To cite this article:

Drapkina OM, Berns SA, Gorshkov AYu, et al. . Thrombodynamics parameters in individuals vaccinated against SARS-CoV-2. Russian Journal of Preventive Medicine. 2021;24(12):24‑30. (In Russ.)
https://doi.org/10.17116/profmed20212412124

 
Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

During the ongoing COVID-19 pandemic, with a significant variety of available vaccines, it is crucial to consider their effects on the hemostasis system.

OBJECTIVE

To study thrombodynamics features of individuals vaccinated against SARS-CoV-2 with Gam-COVID-Vac and CoviVac vaccines in a prospective observational study.

MATERIALS AND METHODS

Data from 99 vaccinated individuals who completed the first three visits were analyzed. Of these, 18 were vaccinated with Gam-COVID-Vac, and 81 with CoviVac. Venous blood was collected before injection of the components I and II of the vaccine and 42 days after administration of the component I to analyze thrombodynamics parameters using the Thrombodynamics Analyzer System T2 (Hemacore, Russia).

RESULTS

In the analysis of thrombodynamics test data, no significant differences were found between the Gam-COVID-Vac group and the CoviVac group at any of the three stages of the study. Moreover, no significant increase in any of the parameters from the visit 1 to visit 3 was observed in both groups.

CONCLUSION

The obtained study data suggest that such plasma hemostasis parameters as stationary rate of clot growth and initial rate of clot growth, lag-time, clot density and clot size, spontaneous clots formation time show no significant changes during 42 days after the component I of Gam-COVID-Vac and CoviVac vaccines injection.

Keywords:

vaccination
coronavirus infection
COVID-19
Gam-COVID-Vac
CoviVac
thrombodynamics
hemostasis system

Authors:

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Berns S.A.

Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of Russia

Gorshkov A.Yu.

National Medical Research Center for Therapy and Preventive Medicine

Yavelov I.S.

National Medical Research Center for Therapy and Preventive Medicine

Shishkova V.N.

National Medical Research Center for Therapy and Preventive Medicine Federal State Budgetary Institution the Ministry of Health of Russia;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry Federal State Budgetary Educational Institution of Higher Education

Ryzhakova L.N.

National Medical Research Center for Therapy and Preventive Medicine

Ivanova A.A.

Federal Scientific Clinical Center for Children and Adolescents

Veretennikova A.V.

National Medical Research Center for Therapy and Preventive Medicine

Karateev R.A.

National Medical Research Center for Therapy and Preventive Medicine

Arablinskiy N.A.

National Medical Research Center for Therapy and Preventive Medicine

Received:

29.11.2021

Accepted:

09.12.2021

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References:

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