Psychosocial factors have been little studied in epidemiological studies, whereas the spectacular material progress in modern society has not yet been balanced by our knowledge about psychobiology, as a result of which it is relevant and timely to study chronic social stressors in the population. Objective: to establish an association between the prevalence of metabolic syndrome (MS) and workplace stress in males aged 25-64 years in an open urban population. Methods. This one-stage epidemiological study was conducted on a representative sample formed from the lists of 25-64-year-old male voters in one of the Tyumen administrative districts. For the analysis the investigators used the 2005 International Diabetes Foundation (IDF) criteria for MS and workplace stress, by applying the WHO MONICA—psychosocial questionnaire «Knowledge and Attitude to One’s Health». Results. In the open urban population of 25-64-year-old males with MS, the groups with MS clusters, such as the concurrences of abdominal obesity, hypertriglyceridemia (HTG), lowered high-density lipoprotein cholesterol ((HDL-C), or abdominal obesity, HTG, and hypertension, were predominantly exposed to work stress. In the same male population with MS, those with MS clusters, such as the concurrences of abdominal obesity, hypertension, and lowered HDL-C, or abdominal obesity, hypertension, and hyperglycemia, were stressed at work to a lesser degree. Conclusion. The analysis of studying the chronic social stressors in the open population showed that measures for the primary prevention of cardiovascular diseases should be aimed to correct workplace stress among the able-bodied males with metabolic syndrome that includes mainly the clusters with abdominal obesity and hypertension concurrent with lowered HDL-C or hyperglycemia.