Abstract Background. The relevance of studying the quality of life (QoL) in patients with alopecia is due to the fact that these generally mild conditions can have a significant negative impact on psychological and social functioning. Objective — the aim of the study was to identify of social, clinical, and psychosomatic parameters associated with reduction of QoL in alopecia as potential targets for secondary prevention. Material and methods. The 106 patients (86 women; mean age — 36.9 years (SD 13.5 years)) with different types of alopecia: alopecia areata (n=22), androgenetic alopecia (n=39), telogen effluvium (n=36) and primary cicatrical alopecia (n=9) were examined interdisciplinary. The QoL was estimated by two scales: Dermatological Life Quality index (DLQI) and Hair Specific SKINDEX-29 (HSS-29). The association of QoL on sociodemographic (gender, age), clinical (type, duration and severity alopecia) psychosomatic parameters (anxiety, depression, and personality disorders), was evaluated. Results. The QoL decrease in alopecia patients was significantly associated with younger age, the alopecia type (alopecia areata), and psychosomatic disorders (anxiety, depression, personality disorder). There was no significant relation of QoL with severity and duration of baldness, and patient’s gender. The positive significant correlation between two QoL estimates (DLQI and HSS-29) has been found. This indicates the consistency of QoL estimation with these two instruments. However, the using of HSS-29 for alopecia patients could give some advantages: the assessment of QoL with three subscales of HSS-29 (symptoms, functions, and emotions) allows to detect the most affected QoL dimensions. It could be crucial for targeting correction and further secondary prevention of QoL decrease. Conclusion. The poor QoL in patients with alopecia is potentially associated with alopecia diagnosis, younger age and psychosomatic disorders, which should be taken in consideration by dermatologists to prevent further QoL decline. Psychosomatic disorders, as potentially modifiable parameters, are considered to be important targets for secondary prevention of QoL reduction in patients with alopecia.