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Boyarsky K.Yu.

Center for Reproduction “Genesis”;
Mechnikov North-West State Medical University

Kriazheva E.A.

Center for Reproduction “Genesis”

Arnt O.S.

Mechnikov North-West State Medical University

Kahiani E.I.

Mechnikov North-West State Medical University

Unresolved questions of recurrent implantation failure

Authors:

Boyarsky K.Yu., Kriazheva E.A., Arnt O.S., Kahiani E.I.

More about the authors

Journal: Russian Journal of Human Reproduction. 2025;31(3): 42‑47

DOI: 10.17116/repro20253103142

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Table of contents

UNRESOLVED QUESTIONS OF RECURRENT IMPLANTATION FAILURE
UNRESOLVED QUESTIONS OF RECURRENT IMPLANTATION FAILURE

To cite this article:

Boyarsky KYu, Kriazheva EA, Arnt OS, Kahiani EI. Unresolved questions of recurrent implantation failure. Russian Journal of Human Reproduction. 2025;31(3):42‑47. (In Russ.)
https://doi.org/10.17116/repro20253103142

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Recurrent implantation failure (RIF) is a clinical condition in which viable embryos fail to implant when transferred into the uterine cavity. Recently published ESHRE guidelines and other studies are calling for a new look at the problem of RIF, especially when using euploid embryo transfer. The review examines modern methods of overcoming RIF, proposed in clinical guidelines.

Keywords:

recurrent implantation failure
euploid embryo
clinical guidelines

Authors:

Boyarsky K.Yu.

Center for Reproduction “Genesis”;
Mechnikov North-West State Medical University

Kriazheva E.A.

Center for Reproduction “Genesis”

Arnt O.S.

Mechnikov North-West State Medical University

Kahiani E.I.

Mechnikov North-West State Medical University

Received:

05.12.2023

Accepted:

26.11.2024

Close metadata

References:

  1. ESHRE Working Group on Recurrent Implantation Failure; Cimadomo D, de Los Santos MJ, Griesinger G, Lainas G, Le Clef N, McLernon DJ, Montjean D, Toth B, Vermeulen N, Macklon N. ESHRE good practice recommendations on recurrent implantation failure. Hum Reprod Open. 2023 June 15;2023(3):hoad023. https://doi.org/10.1093/hropen/hoad023
  2. Pirtea P, De Ziegler D, Tao X, Sun L, Zhan Y, Ayoubi JM, Seli E, Franasiak JM, Scott RT Jr. Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers. Fertility and Sterility. 2021;115(1):45-53.  https://doi.org/10.1016/j.fertnstert.2020.07.002
  3. (The writing group) for the participants to the 2022 Lugano RIF Workshop; Pirtea P, Cedars MI, Devine K, Ata B, Franasiak J, Racowsky C, Toner J, Scott RT, de Ziegler D, Barnhart KT. Recurrent implantation failure: reality or a statistical mirage?: Consensus statement from the July 1, 2022 Lugano Workshop on recurrent implantation failure. Fertility and Sterility. 2023;120(1):45-59.  https://doi.org/10.1016/j.fertnstert.2023.02.014
  4. Ata B, Kalafat E, Somigliana E. A new definition of recurrent implantation failure on the basis of anticipated blastocyst aneuploidy rates across female age. Fertility and Sterility. 2021;116(5):1320-1327. https://doi.org/10.1016/j.fertnstert.2021.06.045
  5. Mackens S, Loreti S, Goyens E, De Vos M. O-145 From mathematical modeling to real-life clinical data: live birth rates up until the tenth blastocyst transfer without PGT-A. Human Reproduction. 2023;38(Suppl 1):dead093-172.  https://doi.org/10.1093/humrep/dead093.172
  6. Ata B, Liñán A, Kalafat E, Ruíz F, Melado L, Bayram A, Elkhatib I, Lawrenz B, Fatemi HM. Effect of the endometrial thickness on the live birth rate: insights from 959 single euploid frozen embryo transfers without a cutoff for thickness. Fertility and Sterility. 2023;120(1):91-98.  https://doi.org/10.1016/j.fertnstert.2023.02.035
  7. Remohí J, Ardiles G, García-Velasco JA, Gaitán P, Simón C, Pellicer A. Endometrial thickness and serum oestradiol concentrations as predictors of outcome in oocyte donation. Human Reproduction. 1997;12(10):2271-2276. https://doi.org/10.1093/humrep/12.10.2271
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  9. Richter KS, Richter ML. Personalized embryo transfer reduces success rates because endometrial receptivity analysis fails to accurately identify the window of implantation. Human Reproduction. 2023; 38(7):1239-1244. https://doi.org/10.1093/humrep/dead083
  10. Glujovsky D, Lattes K, Miguens M, Pesce R, Ciapponi A. Personalized embryo transfer guided by endometrial receptivity analysis: a systematic review with meta-analysis. Human Reproduction. 2023; 38(7):1305-1317. https://doi.org/10.1093/humrep/dead098
  11. Pinborg A, Bentzen J, Bozdag G, Ebner T. Add-ons in the ART clinic. Human Reproduction. 2023;38(Suppl 1):dead093.121.  https://doi.org/10.1093/humrep/dead093.121
  12. Lundin K, Bentzen J, Bozdag G, Ebner T. O-101 Add-ons in the ART lab. Human Reproduction. 2023;38(Suppl 1):dead093-120.  https://doi.org/10.1093/humrep/dead093.120
  13. Cimadomo D, Rienzi L, Conforti A, Forman E, Canosa S, Innocenti F, Poli M, Hynes J, Gemmell L, Vaiarelli A, Alviggi C, Ubaldi FM, Capalbo A. Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis. Human Reproduction Update. 2023;29(5):570-633.  https://doi.org/10.1093/humupd/dmad010
  14. Hanstede MMF, van der Meij E, Veersema S, Emanuel MH. Live births after Asherman syndrome treatment. Fertility and Sterility. 2021;116(4):1181-1187. https://doi.org/10.1016/j.fertnstert.2021.05.099
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