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Talanova I.E.

Ivanovo State Medical Academy;
Gorodkov Ivanovo Research Institute of Motherhood and Childhood

Malyshkina A.I.

Ivanovo State Research Institute of Maternity and Childhood n.a. V.N. Gorodkov

Borzova N.Yu.

Gorodkov Ivanovo Research Institute of Maternity and Childhood

Sotnikova N.Yu.

Ivanovo State Medical Academy;
Ivanovo Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Smirnova A.V.

Ivanovo State Medical Academy

Premature rupture of membranes in preterm pregnancy: pathogenetic mechanisms and prognosis

Authors:

Talanova I.E., Malyshkina A.I., Borzova N.Yu., Sotnikova N.Yu., Smirnova A.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2022;28(6): 110‑115

DOI: 10.17116/repro202228061110

Read: 1586 times

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Table of contents

PREMATURE RUPTURE OF MEMBRANES IN PRETERM PREGNANCY: PATHOGENETIC MECHANISMS AND PROGNOSIS
PREMATURE RUPTURE OF MEMBRANES IN PRETERM PREGNANCY: PATHOGENETIC MECHANISMS AND PROGNOSIS

To cite this article:

Talanova IE, Malyshkina AI, Borzova NYu, Sotnikova NYu, Smirnova AV. Premature rupture of membranes in preterm pregnancy: pathogenetic mechanisms and prognosis. Russian Journal of Human Reproduction. 2022;28(6):110‑115. (In Russ.)
https://doi.org/10.17116/repro202228061110

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Premature rupture of membranes is one of the leading causes of preterm birth and associated high rates of perinatal morbidity and mortality. The development of premature rupture of amniotic fluid in preterm pregnancy is due to the influence of risk factors, has a polyetiology and complexity of pathogenesis. This article presents information on the current state of the problem, on the causes of the development of premature rupture of the membranes, sets out different and at the same time unified views on the pathogenesis of this complication of pregnancy, and also presents data from our own studies. One of the mechanisms of premature rupture of the membranes is the migration of neutrophils to the zone of fetal-placental contact with the release of a number of cytokines, including chemokines, causing directed migration of leukocytes, increased synthesis of collagenase and elastase, which break down the extracellular matrix. According to our data, when determining the level of chemokine IL-8 in the peripheral blood of pregnant women with the threat of miscarriage equal to or less than 15.4 ng/ml, it is possible to predict premature rupture of amniotic fluid. The accuracy of this method was 86%, sensitivity 90% and specificity 81%. Given the significant contribution of this pathology to perinatal morbidity and mortality, there is a need for further studies of the etiology, pathogenesis, and the search for new prognostic markers of prom.

Keywords:

premature pregnancy
premature rupture of membranes
apoptosis
oxidative stress
macrophages
chemokines

Authors:

Talanova I.E.

Ivanovo State Medical Academy;
Gorodkov Ivanovo Research Institute of Motherhood and Childhood

Malyshkina A.I.

Ivanovo State Research Institute of Maternity and Childhood n.a. V.N. Gorodkov

Borzova N.Yu.

Gorodkov Ivanovo Research Institute of Maternity and Childhood

Sotnikova N.Yu.

Ivanovo State Medical Academy;
Ivanovo Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Smirnova A.V.

Ivanovo State Medical Academy

Received:

21.02.2022

Accepted:

31.05.2022

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