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Okulova E.O.

Ural Scientific Research Institute of Maternity and Child Care Public Health’s Ministry of the Russian Federation

Mikhelson A.A.

Ural Scientific Research Institute of Maternity and Child Care Public Health’s Ministry of the Russian Federation

Melkozerova O.A.

Ural Research Institute for Maternity and Child Care, Ministry of Public Health of the Russian Federation

Telyakova M.I.

Ural Scientific Research Institute of Maternity and Child Care Public Health’s Ministry of the Russian Federation

Chistyakova G.N.

Ural Research Institute for Maternity and Child Care, Ministry of Public Health of the Russian Federation

Lazukina M.V.

Ural Research Institute of Maternity and Child Care

Endometriosis of a post-cesarean incompetent of uterine scar: inflammatory or connective tissue dysplasia

Authors:

Okulova E.O., Mikhelson A.A., Melkozerova O.A., Telyakova M.I., Chistyakova G.N., Lazukina M.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2022;28(4): 145‑150

DOI: 10.17116/repro202228041145

Read: 1981 times

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Table of contents

ENDOMETRIOSIS OF A POST-CESAREAN INCOMPETENT OF UTERINE SCAR: INFLAMMATORY OR CONNECTIVE TISSUE DYSPLASIA
ENDOMETRIOSIS OF A POST-CESAREAN INCOMPETENT OF UTERINE SCAR: INFLAMMATORY OR CONNECTIVE TISSUE DYSPLASIA

To cite this article:

Okulova EO, Mikhelson AA, Melkozerova OA, Telyakova MI, Chistyakova GN, Lazukina MV. Endometriosis of a post-cesarean incompetent of uterine scar: inflammatory or connective tissue dysplasia. Russian Journal of Human Reproduction. 2022;28(4):145‑150. (In Russ.)
https://doi.org/10.17116/repro202228041145

 
Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To analyze the morpho-functional state of the endometrium and the scar tissue of the myometrium in patients with post-cesarean endometriosis in an incompetent uterine scar.

MATERIAL AND METHODS

The study included 16 patients with histologically confirmed endometriosis of an untenable scar on the uterus and 38 patients with untenable scar on the uterus from cesarean section without endometriosis. Morphological and immunohistochemical studies of excised scar tissue and endometrial samples were performed.

RESULTS

The combination of uterine scar failure with endometriosis was associated with a lower myometrial thickness in the scar area according to MRI data compared to the group without endometriosis. The expression of progesterone receptors of the endometrial glands was significantly reduced in the group of patients with scar endometriosis compared to the group without endometriosis. In the immunohistochemical study of excised untenable scars tissue on the uterus, the expression of CD3, which is a tissue marker of T-lymphocytes, was significantly higher in the endometriosis group than in the comparison group. The expression of vascular-endothelial growth factor VEGFR-1 was higher in the absence of scar endometriosis than in the presence of it. In the scar tissue with endometriosis the expression of type 1 collagen was significantly higher than in the comparison group.

CONCLUSIONS

The combination of failure of the uterine scar from cesarean section with endometriosis is associated with a more significant depletion of the myometrium in the scar area. In endometrioid lesions of the uterine scar its failure may be due to the inflammatory process. If the scar on the uterus fails after cesarean section without endometriosis, there is a defect in collagen synthesis and a violation of vascularization.

Keywords:

uterine scar failure
endometriosis

Authors:

Okulova E.O.

Ural Scientific Research Institute of Maternity and Child Care Public Health’s Ministry of the Russian Federation

Mikhelson A.A.

Ural Scientific Research Institute of Maternity and Child Care Public Health’s Ministry of the Russian Federation

Melkozerova O.A.

Ural Research Institute for Maternity and Child Care, Ministry of Public Health of the Russian Federation

Telyakova M.I.

Ural Scientific Research Institute of Maternity and Child Care Public Health’s Ministry of the Russian Federation

Chistyakova G.N.

Ural Research Institute for Maternity and Child Care, Ministry of Public Health of the Russian Federation

Lazukina M.V.

Ural Research Institute of Maternity and Child Care

Received:

18.01.2021

Accepted:

22.05.2022

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References:

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