Ovarian stimulation and oocyte quality

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Ovarian stimulation (OS) affects the clinical outcomes of assisted reproductive technologies (ART). The number of oocytes obtained during IVF may depend on the protocols of ovarian stimulation, the dosage of gonadotropins and the duration of stimulation. However, the impact of OS on the quality of oocytes and embryos is still unclear. In this review, we considered the main aspects of the possible impact of pre-treatment and adjuvant therapy, OS protocols, the time of starting the administration of gonadotropins, dosages, types of gonadotropins, duration of OS, types of trigger used for the final maturation of oocytes, the follicle diameter and the time of transvaginal follicle puncture on the quality of obtained oocytes and clinical outcomes of ART cycles. In this review, we considered the main aspects of the possible impact of pre-treatment and adjuvant therapy, OS protocols, the time of the start of gonadotropin administration, dosages, types of gonadotropins, OS duration, types of trigger used for final maturation of oocytes, follicle diameter and time of oocyte pick up on the quality of the obtained oocytes and clinical outcomes of IVF cycles.

Keywords:

oocyte quality

ovarian stimulation

IVF

infertility

Authors:

Yakovlev P.P.

Centre for Reproductive Medicine Co. Ltd. «Next Generation Clinic»

Kogan I.Yu.

Ott Scientific Research Institute of Obstetrics, Gynecology and Reproductology;
St. Petersburg State University

Received:

12.08.2021

Accepted:

17.04.2022

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