Dynamics of hormonal and pro-inflammatory status, metabolic parameters and oxidative stress in patients with impaired ovarian function against the background of weight loss

Glazkova O.L.; Shmeleva S.V.; Dubrovinskaya E.I.; Kachalov S.B.

doi:https://doi.org/10.17116/repro20222802153

Glazkova O.L.

Russian Medical Academy for Continuous Professional Education

Shmeleva S.V.

Razumovsky Moscow State University of Technology and Management

Dubrovinskaya E.I.

FSBEI VO MGUTU — Moscow State University of Technology and Management named after K.G. Razumovsky (PKU)

Kachalov S.B.

State University of Management (GUU)

Dynamics of hormonal and pro-inflammatory status, metabolic parameters and oxidative stress in patients with impaired ovarian function against the background of weight loss

Authors:

Glazkova O.L., Shmeleva S.V., Dubrovinskaya E.I., Kachalov S.B.

More about the authors

Journal: Russian Journal of Human Reproduction. 2022;28(2): 53‑58

DOI: 10.17116/repro20222802153

Read: 1015 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Glazkova OL, Shmeleva SV, Dubrovinskaya EI, Kachalov SB. Dynamics of hormonal and pro-inflammatory status, metabolic parameters and oxidative stress in patients with impaired ovarian function against the background of weight loss. Russian Journal of Human Reproduction. 2022;28(2):53‑58. (In Russ.)
https://doi.org/10.17116/repro20222802153

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)

Использование инфографики авторами научных работ

Close metadata

Abstract:

OBJECTIVE

Of the study was to study the state of the reproductive system in relation to the parameters of carbohydrate and lipid metabolism, oxidative stress and pro-inflammatory status in patients with menstrual irregularities and obesity against the background of effective weight loss.

MATERIALS AND METHODS

We examined 52 obese women aged 20 to 35 years (30.9 years (27.3; 32.5)) who signed voluntary informed consent to participate in the study, with the main complaint of the patients being menstrual irregularities.

RESULTS

PCOS was diagnosed in 38 women. Body mass index varied from 27 to 44 kg/m² (34.3 (32.2; 41.2) kg/m²). The patients were prescribed an individual hypocaloric diet. A statistically significant improvement in performance took place after a 2 kg/m² decrease in BMI. Decreased concentrations of insulin on an empty stomach and after exercise, total cholesterol, testosterone. The concentration of PSH and progesterone increased on the 23—25 day of the cycle. The leptin concentration decreased compared to the background of 48.3 ng/ml (28.4; 68.3) to 42.3 ng/ml (31.3; 61.5) p=0.11 after a decrease in BMI by 1 kg/m² and up to 21.3 ng/ml (13.5; 48.,3) p=0.01 after a decrease in BMI by 2 kg/m². Indicators of the concentration of malondialdehyde in the same period were 3.0 nmol/ml (1.7; 3.7), 2.9 nmol/ml (1.6; 3.1) p=0.59 and 1.6 nmol/ml (0.7; 2.2) p=0.015, and CRP 3.4 ng/ml (2.9; 3.7), 3.1 ng/ml (2.5; 3.3) p=0.28 and 1.9 ng/ml (0.7; 2.1) p=0.02. Further, the dynamics were less significant.

CONCLUSIONS

We consider a decrease in BMI by 2 kg/m² to be mandatory when planning treatment for patients with impaired ovarian function and obesity. Further weight loss is undoubtedly welcome, but it can be done at a fairly slow pace.

Keywords:

obesity

menstrual irregularities

insulin resistance

oxidative stress

malondialdehyde

leptin

C-reactive protein

Authors:

Glazkova O.L.

Russian Medical Academy for Continuous Professional Education

Shmeleva S.V.

Razumovsky Moscow State University of Technology and Management

Dubrovinskaya E.I.

FSBEI VO MGUTU — Moscow State University of Technology and Management named after K.G. Razumovsky (PKU)

Kachalov S.B.

State University of Management (GUU)

Received:

08.11.2021

Accepted:

11.01.2022

Close metadata

References:

Abu Ali ibn Sina (Avicenna). Kanon vrachebnoj nauki. Amrita; 2007. (In Russ.).
Klenov VE, Jungheim ES. Obesity and Reproductive Function: A Review of the Evidence. Current Opinion in Obstetrics and Gynecology. 2014;26(6):455-460. https://doi.org/10.1097/GCO.0000000000000113
Ciaraldi TP, Aroda V, Mudaliar S, Chang RJ, Henry RR. Polycystic ovary syndrome is associated with tissue-specific differences in insulin resistance. The Journal of Clinical Endocrinology and Metabolism. 2009;94(1):157-163. https://doi.org/10.1210/jc.2008-1492
Wei S, Schmidt MD, Dwyer T, Norman RJ, Venn AJ. Obesity and menstrual irregularity: associations with SHBG, testosterone, and insulin. Obesity. 2009;17(5):1070-1076. https://doi.org/10.1038/oby.2008.641
Broughton DE, Moley KH. Review. Obesity and female infertility: potential mediators of obesity’s impact. Fertility and Sterility. 2017; 107(4):840-847. https://doi.org/10.1016/j.fertnstert.2017.01.017
Lee H, Oh JY, Sung YA. Adipokines, insulin-like growth factor binding protein-3 levels, and insulin sensitivity in women with polycystic ovary syndrome. The Korean Journal of Internal Medicine. 2013; 28(4):456-463. https://doi.org/10.3904/kjim.2013.28.4.456
Kelesidis T, Kelesidis I, Chou S, Mantzoros CS. Narrative review: the role of leptin in human physiology: emerging clinical applications. Annals of Internal Medicine. 2010;152(2):93-100. https://doi.org/10.7326/0003-4819-152-2-201001190-00008
Li J, Li F, Zhao A. Inflammation and leptin. Drug Discovery Today: Disease Mechanisms. 2006;3(3):387-393.
Kirschner MA, Samojlik E, Silber D. A comparison of androgen production and clearance in hirsute and obese women. Journal of Steroid Biochemistry. 1983;19(1B):607-614. https://doi.org/10.1016/0022-4731(83)90225-x
Samojlik E, Kirschner MA, Silber D, Schneider G, Ertel NH. Elevated production and metabolic clearance rates of androgens in morbidly obese women. The Journal of Clinical Endocrinology and Metabolism. 1984;59(5):949-954. https://doi.org/10.1210/jcem-59-5-949
Gambineri A, Fanelli F, Tomassoni F, Munarini A, Pagotto U, Andrew R, Walker BR, Pasquali R. Tissue-specific dysregulation of 11β-hydroxysteroid dehydrogenase type 1 in overweight/obese women with polycystic ovary syndrome compared with weight-matched controls. European Journal of Endocrinology. 2014;171(1):47-57. https://doi.org/10.1530/EJE-13-1030
Goldsammler M, Merhi Z, Buyuk E. Role of hormonal and inflammatory alterations in obesity-related reproductive dysfunction at the level of the hypothalamic-pituitary-ovarian axis. Reproductive Biology and Endocrinology: RB&E. 2018;16(1):45. https://doi.org/10.1186/s12958-018-0366-6
Klychnikova EV, Matveev SB, Riabinin VA, Godkov MA, Golikov AP, Akhmetov VV, Mikhaĭlov IP. [The oxidation stress, lipid metabolism and their relationship in patients with severe course of hypertension disease in aggregate with carotid stenosis]. Klinicheskaia laboratornaia diagnostika. 2012;(5):20-22. (In Russ.).
Zaharov IS, Bukreeva EL. Oxidative stress in polycystic ovary syndrome: prognostic value, correction possibilities. Ginekologiya. 2018; 20(1):35-38. (In Russ.). https://doi.org/10.26442/2079-5696 20.1.35-38
Volodina MA, Hashchenko EP, Uvarova EV, Vysokih MYu, Pyataeva SV, Suhanova YuA, Tarasova NV, Suhih GT. Pathological manifestations of systemic oxidative stress on the background of mitochondrial dysfunction in adolescents with polycystic ovary syndrome. Reproduktivnoe zdorov’e detej i podrostkov. 2016;2:61-65. (In Russ.).
Podzolkova NM, Glazkova OL, Poletova TN, Nazarova SV. Dynamics of hormonal status and indicators of carbohydrate and lipid metabolism in obese patients against the background of weight loss. Problemy reprodukcii. 2015;21(5):43-49. (In Russ.). https://doi.org/10.17116/repro201521543-48
Glazkova OL, Shmeleva SV, Poletova TN, Gaponova NM. Dynamics of metabolic disorders in obese women who underwent hysterectomy: justification of the need for restorative treatment. Vestnik vosstanovitel’noj mediciny. 2013;55(3):59-63. (In Russ.).
Glazkova OL, Shmeleva SV, Poletova TN, Nazarova SV. Dynamics of parameters of carbohydrate, lipid metabolism, as well as hormonal status of patients with ovarian dysfunction at the initial stages of obesity therapy. Profilakticheskaya i klinicheskaya medicina. 2015;55(2):45-51. (In Russ.).
Glazkova OL, Shmeleva SV. Indicators of carbohydrate, lipid and oxidative stress metabolism in patients with menstrual disorders and obesity. Akusherstvo i ginekologiya. 2021;1:104-109. (In Russ.). https://doi.org/10.18565/aig.2021.1.104-109
Dedov II, Shestakova MV, Mel’nichenko GA, Mazurina NV, Andreeva EN, Bondarenko IZ, Gusova ZR, Dzgoeva FH, Eliseev MS, Ershova EV, Zhuravleva MV, Zaharchuk TA, Isakov VA, Klepikova MV, Komshilova KA, Krysanova VS, Nedogoda SV, Novikova AM, Ostroumova OD, Pereverzev AP, Rozhivanov RV, Romancova TI, Ruyatkina LA, Salasyuk AS, Sasunova AN, Smetanina SA, Starodubova AV, Suplotova LA, Tkacheva ON, Troshina EA, Hamoshina MB, Chechel’nickaya SM, Shestakova EA, Sheremet’eva EV. Interdisciplinary clinical guidelines «Treatment of obesity and comorbid diseases». Ozhirenie i metabolizm. 2021;18(1):5-99. (In Russ.). https://doi.org/10.14341/omet12714