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Mikhaylyukova A.S.

Clinic for Assisted Reproductive Technologies «Test-tube babies»

Vartanyan E.V.

Department of Obstetrics and Gynecology of Pirogov Russian National Research Medical University;
Clinic for Assisted Reproductive Technologies «Test-tube babies»

Dobrokhotova Yu.E.

Pirogov Russian National Research Medical University

Tsaturova K.A.

Clinic for Assisted Reproductive Technologies «Test-tube babies»

Devyatova E.A.

Clinic for Assisted Reproductive Technologies «Test-tube babies»

S Kuz’micheva V.

Moscow Regional Research Institute of Obstetrics and Gynecology

Modern approach to the evaluation of the quality of oocytes in programs of in vitro fertilization (literarure review)

Authors:

Mikhaylyukova A.S., Vartanyan E.V., Dobrokhotova Yu.E., Tsaturova K.A., Devyatova E.A., S Kuz’micheva V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2021;27(4): 127‑134

DOI: 10.17116/repro202127041127

Read: 1917 times

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Table of contents

MODERN APPROACH TO THE EVALUATION OF THE QUALITY OF OOCYTES IN PROGRAMS OF IN VITRO FERTILIZATION (LITERARURE REVIEW)
MODERN APPROACH TO THE EVALUATION OF THE QUALITY OF OOCYTES IN PROGRAMS OF IN VITRO FERTILIZATION (LITERARURE REVIEW)

To cite this article:

Mikhaylyukova AS, Vartanyan EV, Dobrokhotova YuE, Tsaturova KA, Devyatova EA, S Kuz’micheva V. Modern approach to the evaluation of the quality of oocytes in programs of in vitro fertilization (literarure review). Russian Journal of Human Reproduction. 2021;27(4):127‑134. (In Russ.)
https://doi.org/10.17116/repro202127041127

 
Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

High gynecological morbidity and somatic diseases lead to poor reproductive health and form high infertility rates. The need for the use of assisted reproductive technologies (ART) as the main high-tech approach to infertility treatment is increasing through the years. The effectiveness of ART is influenced by different points, and the quality of gametes is in priority. The selection of high-quality oocytes for in vitro fertilization is one of the most important stages of the ART program, but there are no uniform clear criteria for this procedure so far.

OBJECTIVES

1) to analyze the state of the problem of oocyte quality assessment using various modern methods for predicting the outcome of ART procedure; 2) to evaluate the scientific data which represent the connection between the concentration of biomarkers in follicular fluid in different state of ovarian reserve.

MATERIAL AND METHODS

Search for studies published in international and Russian databases and electronic resources (MedLine, EMBASE, eLibrary, cyberleninka) on the problem of evaluating of the quality of oocytes in ART using keywords.

RESULTS AND CONCLUSION

Oocyte quality assessment is currently implemented using several approaches: assessment of the oocyte morphology, mitochondrial DNA (mtDNA) and follicular fluid (FF). All these methods provide information about the development of follicles and the quality of the oocytes. The variety of approaches and the lack of an objective system for the evaluation of the quality of oocytes in order to improve the effectiveness of ART programs justify the need for further research.

Keywords:

infertility
follicular fluid (FF)
oocyte quality
IVF
pregnancy

Authors:

Mikhaylyukova A.S.

Clinic for Assisted Reproductive Technologies «Test-tube babies»

Vartanyan E.V.

Department of Obstetrics and Gynecology of Pirogov Russian National Research Medical University;
Clinic for Assisted Reproductive Technologies «Test-tube babies»

Dobrokhotova Yu.E.

Pirogov Russian National Research Medical University

Tsaturova K.A.

Clinic for Assisted Reproductive Technologies «Test-tube babies»

Devyatova E.A.

Clinic for Assisted Reproductive Technologies «Test-tube babies»

S Kuz’micheva V.

Moscow Regional Research Institute of Obstetrics and Gynecology

Received:

10.09.2020

Accepted:

12.12.2020

Close metadata

References:

  1. Abbara A, Clarke SA, Dhillo WS. Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment. Endocrine Reviews. 2018;39(5):593-628.  https://doi.org/10.1210/er.2017-00236
  2. Ustinova TA, Artymuk NV, Vlasova VV, Pyzhov AYa. Infertility in the Kemerovo region. Mat’ i ditja v Kuzbasse. 2010;1(40):37-39. (In Russ.).
  3. Frolova NI, Belokrinickaja TE, Anohova LI, Kadalova NV, Lugovskaya OV, Yakimova YV, Ananjina DA, Turanova OV. Prevalence and characteristics of infertility in young women of reproductive age living in Zabaykalsky district. Acta Biomedica Scientifica. 2014;4:54-58. (In Russ).
  4. Darzhaev ZY, Atalyan AV, Rinchindorzhiyeva MP, Suturina LV. Prevalence of female infertility among urban and rural population in Buryat Republic. Fundamental’naya i klinicheskaya medicina. 2017;2(4):14-21. (In Russ.).
  5. Podzolkova NM, Shamugija NL, Koloda JuA, Skvorcova MJu. Besplodie. Diagnostika, sovremennye metody lechenija. M.: GJEOTAR-Media; 2018. (In Russ.).
  6. Sun H, Gong TT, Jiang YT, Zhang S, Zhao YH, Wu QJ. Global, regional, and national prevalence and disability-adjusted life-years for infertility in 195 countries and territories, 1990—2017: results from a global burden of disease study, 2017. Aging. 2019;11(23):10952-10991. https://doi.org/10.18632/aging.102497
  7. March WA, Moore VM, Willson KJ, Phillips DI, Norman RJ, Davies MJ. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Human Reproduction. 2010;25(2):544-551.  https://doi.org/10.1093/humrep/dep399
  8. Yildiz BO, Bozdag G, Yapici Z, Esinler I, Yarali H. Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria. Human Reproduction. 2012;27(10): 3067-3073. https://doi.org/10.1093/humrep/des232
  9. Joham AE, Teede HJ, Ranasinha S, Zoungas S, Boyle J. Prevalence of infertility and use of fertility treatment in women with polycystic ovary syndrome: data from a large community-based cohort study. Journal of Women’s Health. 2015;24(4):299-307.  https://doi.org/10.1089/jwh.2014.5000
  10. Dennett CC, Simon J. The role of polycystic ovary syndrome in reproductive and metabolic health: overview and approaches for treatment. Diabetes Spectrum. 2015;28(2):116-120.  https://doi.org/10.2337/diaspect.28.2.116
  11. Lee D, Kim SK, Lee JR, Jee BC. Management of endometriosis-related infertility: Considerations and treatment options. Clinical and Experimental Reproductive Medicine. 2020;47(1):1-11.  https://doi.org/10.5653/cerm.2019.02971
  12. Rossijskaja Associacija Reprodukcii cheloveka. Registr VRT. Otche tza 2016 god. SPb.: Izdatel’stvo «Tipografija»; 2018. (In Russ.).
  13. ESHRE Annual Report, 2017. Accessed July 27, 2020. https://www.eshre.eu/-/media/sitecore-files/AboutESHRE/913479_ESHRE_AnnualReport2017_WEB_DEF.pdf?la=en&hash=47C0F3A9BE8ECFA7DD5DF306F899CEB2ABCF920F
  14. Hoshino Y. Updating the markers for oocyte quality evaluation: intracellular temperature as a new index. Reproductive Medicine and Biology. 2018;17(4):434-441.  https://doi.org/10.1002/rmb2.12245
  15. Krasnoshhoka OE, Smol’nikova VJu, Kalinina EA, Elagin VV. The role of morphological assessment of the oocyte and embryo in the use of ART (literature review). Problemy reprodukcii. 2015;21(1):54-58. (In Russ.). https://doi.org/10.17116/repro20152154-58
  16. Makarova NP, Kalinina EA. Criteria for assessing the quality of the oocyte in ICSI cycles: the view of a clinical embryologist. Ginekologiya. 2012;14(3):24-28. (In Russ.).
  17. Ebner T, Moser M, Sommergruber M, Gaiswinkler U, Shebl O, Jesacher K, Tews G. Occurrence and developmental consequences of vacuoles throughout preimplantation development. Fertility and Sterility. 2005;83(6):1635-1640. https://doi.org/10.1016/j.fertnstert.2005.02.009
  18. Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Human Reproduction. 2011;26(6):1270-1283. https://doi.org/10.1093/humrep/der037
  19. Otsuki J, Nagai Y, Chiba K. Damage of embryo development caused by peroxidized mineral oil and its association with albumin in culture. Fertility and Sterility. 2009;91(5):1745-1749. https://doi.org/10.1016/j.fertnstert.2008.03.001
  20. Otsuki J, Nagai Y, Chiba K. Lipofuscin bodies in human oocytes as an indicator of oocyte quality. Journal of Assisted Reproduction and Genetics. 2007;24(7):263-270.  https://doi.org/10.1007/s10815-007-9130-0https://doi.org/10.1016/j.fertnstert.2008.03.001
  21. Kodyleva TA, Shafei RA, Lapina VS, Mishieva NG, Korol’kova AI, Semenova ML, Abubakirov AN. Morphological evaluation of human oocytes in the clinical practice of in vitro fertilization (literature review). Problemy reprodukcii. 2017;23(6):54-59. (In Russ.). https://doi.org/10.17116/repro201723654-59
  22. Jansen RP. Germline passage of mitochondria: quantitative considerations and possible embryological sequelae. Human Reproduction. 2000;15(suppl 2):112-128.  https://doi.org/10.1093/humrep/15.suppl_2.112
  23. Murakoshi Y, Sueoka K, Takahashi K, Sato S, Sakurai T, Tajima H, Yoshimura Y. Embryo developmental capability and pregnancy outcome are related to the mitochondrial DNA copy number and ooplasmic volume. Journal of Assisted Reproduction and Genetics. 2013; 30(10):1367-1375. https://doi.org/10.1007/s10815-013-0062-6
  24. Reynier P, May-Panloup P, Chrétien MF, Morgan CJ, Jean M, Savagner F, Barrière P, Malthièry Y. Mitochondrial DNA content affects the fertilizability of human oocytes. Molecular Human Reproduction. 2001;7(5):425-429.  https://doi.org/10.1093/molehr/7.5.425
  25. Rodgers RJ, Irving-Rodgers HF. Formation of the ovarian follicular antrum and follicular fluid. Biology of Reproduction. 2010;82(6): 1021-1029. https://doi.org/10.1095/biolreprod.109.082941
  26. Basuino L, Silveira CF Jr. Human follicular fluid and effects on reproduction. JBRA Assisted Reproduction. 2016;20(1):38-40.  https://doi.org/10.5935/1518-0557.20160009
  27. Walters KA, Eid S, Edwards MC, Thuis-Watson R, Desai R, Bowman M, Marren AJ, Handelsman DJ. Steroid profiles by liquid chromatography-mass spectrometry of matched serum and single dominant ovarian follicular fluid from women undergoing IVF. Reproductive Biomedicine Online. 2019;38(1):30-37.  https://doi.org/10.1016/j.rbmo.2018.10.006
  28. Kedem-Dickman A, Maman E, Yung Y, Yerushalmi GM, Hemi R, Hanochi M, Dor J, Hourvitz A. Anti-Müllerian hormone is highly expressed and secreted from cumulus granulosa cells of stimulated preovulatory immature and atretic oocytes. Reproductive Biomedicine Online. 2012;24(5):540-546.  https://doi.org/10.1016/j.rbmo.2012.01.023
  29. Nagy B, Poto L, Farkas N, Koppan M, Varnagy A, Kovacs K, Papp S, Bohonyi N, Bodis J. Follicular fluid progesterone concentration is associated with fertilization outcome after IVF: a systematic review and meta-analysis. Reproductive Biomedicine Online. 2019;38(6):871-882.  https://doi.org/10.1016/j.rbmo.2018.12.045
  30. O’Brien Y, Wingfield M, O’Shea LC. Anti-Müllerian hormone and progesterone levels in human follicular fluid are predictors of embryonic development. Reproductive Biology and Endocrinology: RB&E. 2019;17(1):47.  https://doi.org/10.1186/s12958-019-0492-9
  31. Emori MM, Drapkin R. The hormonal composition of follicular fluid and its implications for ovarian cancer pathogenesis. Reproductive Biology and Endocrinology: RB&E. 2014;12:60.  https://doi.org/10.1186/1477-7827-12-60
  32. de los Santos MJ, García-Láez V, Beltrán-Torregrosa D, Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Pellicer A, Labarta E. Hormonal and molecular characterization of follicular fluid, cumulus cells and oocytes from pre-ovulatory follicles in stimulated and unstimulated cycles. Human Reproduction. 2012;27(6):1596-1605. https://doi.org/10.1093/humrep/des082
  33. Polyzos NP, Anckaert E, Guzman L, Schiettecatte J, Van Landuyt L, Camus M, Smitz J, Tournaye H. Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ICSI. Human Reproduction. 2014;29(9):2032-2040. https://doi.org/10.1093/humrep/deu156
  34. van de Vijver A, Drakopoulos P, Van Landuyt L, Vaiarelli A, Blockeel C, Santos-Ribeiro S, Tournaye H, Polyzos NP. Vitamin D deficiency and pregnancy rates following frozen-thawed embryo transfer: a prospective cohort study. Human Reproduction. 2016;31(8): 1749-1754. https://doi.org/10.1093/humrep/dew107
  35. Zhao J, Huang X, Xu B, Yan Y, Zhang Q, Li Y. Whether vitamin D was associated with clinical outcome after IVF/ICSI: a systematic review and meta-analysis. Reproductive Biology and Endocrinology: RB&E. 2018;16(1):13.  https://doi.org/10.1186/s12958-018-0324-3
  36. Spinedi E, Cardinali DP. The Polycystic Ovary Syndrome and the Metabolic Syndrome: A Possible Chronobiotic-Cytoprotective Adjuvant Therapy. International Journal of Endocrinology. 2018;2018: 1349868. https://doi.org/10.1155/2018/1349868
  37. Tamura H, Takasaki A, Taketani T, Tanabe M, Kizuka F, Lee L, Tamura I, Maekawa R, Asada H, Yamagata Y, Sugino N. Melatonin as a free radical scavenger in the ovarian follicle. Endocrine Journal. 2013;60(1):1-13.  https://doi.org/10.1507/endocrj.ej12-0263
  38. Poterjaeva ON. Matrix metalloproteinases: structure, regulation, and role in the development of pathological conditions (literature review).Medicina i obrazovanie Sibiri. 2010;5:7. (In Russ.).
  39. Korenovsky YuV, Sinelnikova LM, Filchakova ON, Shabalina YuV, Yershova YG, Fadeyeva NI, Yelchaninova SA. Matriksnye metalloproteazy i ingibitory matriksnyh metalloproteinaz pri beremennosti i rodah. Acta Biomedica Scientifica. 2012;5(2):146-149. (In Russ).
  40. Gershtejn ES, Kushlinskij DN, Adamjan LV, Tereshkina IV, Laktionov KP. Matrix metalloproteinases and their tissue inhibitors in the clinical course and prognosis of ovarian cancer. Molekuljarnaja medicina. 2013;6:11-20. (In Russ.).
  41. Trubnikova LI, Tadzhieva VD, Marinova OA, Abakumova TV. Clinical significance of MMP-1 and TMP-1 levels in the follicular fluid in different outcomes of assisted reproductive technologies. Ul’janovskij mediko-biologicheskij zhurnal. 2017;4:59-68. (In Russ.). https://doi.org/10.23648/UMBJ.2017.28.8741
  42. Fayezi S, Darabi M, Darabi M, Nouri M, Rahimipour A, Mehdizadeh A. Analysis of follicular fluid total phospholipids in women undergoing in-vitro fertilisation. Journal of Obstetrics and Gynaecology. 2014;34(3):259-262.  https://doi.org/10.3109/01443615.2013.851657
  43. Browne RW, Bloom MS, Shelly WB, Ocque AJ, Huddleston HG, Fujimoto VY. Follicular fluid high density lipoprotein-associated micronutrient levels are associated with embryo fragmentation during IVF. Journal of Assisted Reproduction and Genetics. 2009;26(11-12):557-560.  https://doi.org/10.1007/s10815-009-9367-x
  44. Cordeiro FB, Montani DA, Pilau EJ, Gozzo FC, Fraietta R, Turco EGL. Ovarian environment aging: follicular fluid lipidomic and related metabolic pathways. Journal of Assisted Reproduction and Genetics. 2018;35(8):1385-1393. https://doi.org/10.1007/s10815-018-1259-5
  45. Cataldi T, Cordeiro FB, Costa Ldo V, Pilau EJ, Ferreira CR, Gozzo FC, Eberlin MN, Bertolla RP, Cedenho AP, Turco EG. Lipid profiling of follicular fluid from women undergoing IVF: young poor ovarian responders versus normal responders. Human Fertility. 2013; 16(4):269-277.  https://doi.org/10.3109/14647273.2013.852255
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