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Akperbekova I.S.

Tashkent Medical Academy

Ayupova F.M.

Tashkent Medical Academy

Saidjalilova D.D.

Tashkent Medical Academy

Sattarova K.A.

Tashkent Medical Academy

Mirodilova F.B.

Tashkent Medical Academy

The role and significance of the uterine natural killers in healthy pregnancy (literature review)

Authors:

Akperbekova I.S., Ayupova F.M., Saidjalilova D.D., Sattarova K.A., Mirodilova F.B.

More about the authors

Journal: Russian Journal of Human Reproduction. 2020;26(6): 15‑25

DOI: 10.17116/repro20202606115

Read: 6559 times

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Table of contents

THE ROLE AND SIGNIFICANCE OF THE UTERINE NATURAL KILLERS IN HEALTHY PREGNANCY (LITERATURE REVIEW)
THE ROLE AND SIGNIFICANCE OF THE UTERINE NATURAL KILLERS IN HEALTHY PREGNANCY (LITERATURE REVIEW)

To cite this article:

Akperbekova IS, Ayupova FM, Saidjalilova DD, Sattarova KA, Mirodilova FB. The role and significance of the uterine natural killers in healthy pregnancy (literature review). Russian Journal of Human Reproduction. 2020;26(6):15‑25. (In Russ.)
https://doi.org/10.17116/repro20202606115

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The review provides the latest up-to-date data regarding the role and function of uterine natural killer cells (uNK), their origin and differentiation, the effect of cytokines produced by them on the process of placentation and angiogenesis; also reflects the features of the interaction of trophoblast with maternal uNK in physiological pregnancy. In maternal-fetal interface special attention is given to representatives of innate immunity, the so-called uterine natural killers, which, having characteristic phenotypic properties and interacting with trophoblast cells, provide and form not only maternal immunological tolerance, but also participate in the regulation of differentiation of stromal cells, play a key role in vascular remodelling and protect the fetus from the pathological effects of foreign agents. The presence of natural killer cells has been recognised in human endometrium for 30 years, but despite considerable research effort, the role of uNK cells in normal pregnancy remains uncertain. Only a comprehensive assessment of the regulatory effect of uNK cells, taking into account the latest world studies in this field, will allow us to evaluate and understand their key values in the physiological course of pregnancy.

Keywords:

NK cells
pregnancy
trophoblasts
deciduas
placentation
vascular remodeling

Authors:

Akperbekova I.S.

Tashkent Medical Academy

Ayupova F.M.

Tashkent Medical Academy

Saidjalilova D.D.

Tashkent Medical Academy

Sattarova K.A.

Tashkent Medical Academy

Mirodilova F.B.

Tashkent Medical Academy

Received:

30.03.2020

Accepted:

08.06.2020

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